Survival Analysis of Oral Squamous Cell Carcinoma Patients Attending Tertiary Care Centre of North India

Bakshi, Jaimanti; Kaur, Navjot; Tiwana, Harsimran; Verma, Roshan; Panda, Naresh K.; Patro, Sourabha Kumar

doi:10.1007/s13193-020-01187-3

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Examining primary site histology, 96% of our study’s patients had squamous cell carcinoma, with a 65% 5-year survival rate. In contrast, Bakshi et al [ 19 ] reported a lower 5-year survival rate of 58.3% for OCSCC. Fan et al ’s [ 20 ] study on young Chinese patients with OCSCC showed a higher 5-year survival rate of 75%.…”

Section: Discussionmentioning

confidence: 96%

A hospital-based study of survival in oral cancer patients of Tata Memorial Hospital, Mumbai

Lokhande,

Kannusamy,

Oak

et al. 2024

ecancer Journal

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Introduction Oral cancer represents a significant global public health concern, with the death rate for lip and oral cavity malignancies experiencing a 1.40-fold increase worldwide in the past three decades. This retrospective study aimed to comprehensively understand overall survival (OS) and the influence of sociodemographic and clinical factors on patients diagnosed with oral cavity cancer. Materials and methods The study focused on oral cancer patients enrolled in 2016 and treated at Tata Memorial Hospital, Mumbai, with a follow-up period extending to 5 years until 2021. Utilising the Kaplan–Meier technique and log-rank test, we examined OS and variations based on sociodemographic factors, while the Cox proportional hazard model allowed us to investigate the simultaneous impact of multiple factors on OS. Results A total of 1,895 eligible participants were included. The overall 5-year survival rate was 65%. After adjusting for age, gender, education, primary site, tumour grade, TNM staging, treatment intention, status and modality, we found in our study oral cancer patients aged more than 60 years (HR = 1.37, 95% CI: 1.01–1.85, p -value 0.03), patients who had poorly differentiated carcinoma (HR = 2.44, 95% CI: 1.56–3.81, p -value < 0.001), belonged to stage IV as per TNM staging (HR = 2.44, 95% CI: 1.65–3.61, p -value < 0.001), patient who have received partial treatment (HR = 2.44, 95% CI: 1.65–3.61, p -value < 0.001) and only chemotherapy (HR = 3.56, 95% CI: 2.43–5.23, p -value < 0.001) found to have a higher hazard of dying while literate (HR = 0.73, 95% CI: 0.56–0.95, p -value 0.02) are protective. Limitations The retrospective nature of the study posed constraints in exploring additional variable associations. Implication Overall early detection, appropriate treatment, and regular follow-up are critical for improving the survival rate of patients with oral cavity cancer. Conclusion This research proposes that improving the socioeconomic status and promoting proactive treatment-seeking behaviour is crucial for enhancing the survival of oral cancer patients. Cancer hospitals, in collaboration with the wider public healthcare system in India, which includes clinicians and policymakers, should consider these suggestions to enhance cancer treatment and control in low–middle-income countries.

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Section: Discussionmentioning

confidence: 96%

A hospital-based study of survival in oral cancer patients of Tata Memorial Hospital, Mumbai

Lokhande,

Kannusamy,

Oak

et al. 2024

ecancer Journal

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“…14 OSCC patients now have a 60% five-year survival rate in developed countries, such as the United States of America, due to advancements in diagnostic and treatment approaches. 15 Unfortunately, the survival rate in developing nations was lower, i.e., between 48.4 and 55.9% 16,17 , suggesting that further improvements are necessary to enhance the clinical result for OSCC.…”

Section: Incidences Of Oscc and Its Risk Factorsmentioning

confidence: 99%

A Review on the Role of Vascular Endothelial Growth Factor Receptors in Human Papillomavirus-related Oral Squamous Cell Carcinoma

Zawawi

Aziz

Nafi

et al. 2023

imjm

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Oral squamous cell carcinoma (OSCC) is a neoplasm at the epithelial lining of the oral cavity that is prevalent worldwide. Smoking tobacco and consumption of alcohol are the main risk factors for OSCC. However, human papillomavirus (HPV) could also be an aetiological factor for OSCC. Transmission through urogenital contact increases the risk of developing OSCC, especially in developed countries. HPV-related cancer displays different pathogenesis and clinical outcomes. HPV through its oncogene E6 and E7 play a critical role in carcinogenesis by disrupting the DNA repair mechanism and cell cycle. Increased expression of VEGF ligand in HPV-related cancer has been reported in numerous studies. In OSCC, VEGFRs, i.e., VEGFR-1, VEGFR-2, and VEGFR-3, are overexpressed, with a higher expression on VEGFR-2. In HPV-infected OSCC, HPV is associated with VEGF expression. However, VEGFRs show no such association. This review highlights the possible role of angiogenesis in the progression of HPV-related OSCC. Also, it discusses how VEGF/VEGFR regulated the angiogenic activity caused by the HPV infection. Data on VEGF/VEGFR associated with HPV status is limited, and their role in OSCC progression remains unclear. Elucidating the mechanism of angiogenesis in HPV-associated OSCC may help develop strategies for OSCC-targeted therapy.

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Drug Repurposing for, ENT and Head and Neck, Infectious and Oncologic Diseases: Current Practices and Future Possibilities

Patro

Panda

Sharma

2023

Drug Repurposing for Emerging Infectious Diseases and Cancer

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Survival Analysis of Oral Squamous Cell Carcinoma Patients Attending Tertiary Care Centre of North India

Cited by 4 publications

References 29 publications

A hospital-based study of survival in oral cancer patients of Tata Memorial Hospital, Mumbai

A hospital-based study of survival in oral cancer patients of Tata Memorial Hospital, Mumbai

A Review on the Role of Vascular Endothelial Growth Factor Receptors in Human Papillomavirus-related Oral Squamous Cell Carcinoma

Drug Repurposing for, ENT and Head and Neck, Infectious and Oncologic Diseases: Current Practices and Future Possibilities

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