Survival Analysis of Intrahepatic Cholangiocarcinoma After Resection

Cho, Seong Yeon; Park, Sang Jae; Kim, Seong Hoon; Han, Sung Sik; Kim, Young Kyu; Lee, Kwang‐Woong; Lee, Soon Ae; Hong, Eun Kyung; Lee, Woojin; Woo, Sang Myung

doi:10.1245/s10434-010-0938-y

Cited by 123 publications

(129 citation statements)

References 28 publications

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“…In the present study, although the 1-year survival rates were about the same for those with positive and negative resection margins (57.1% vs. 56.7%, respectively), the 3-and 5-year rates were much lower in those with a positive resection margin (8.0% vs. 40.0%, and 0.0% vs. 25%, respectively). Whereas the studies by Cho et al (2010) and Ribero et al (2010) included only 6.4% and 12% (respectively) with a positive resection margin, the majority of patients (58.9%) in the present study had a positive resection margin.…”

Section: Discussioncontrasting

confidence: 65%

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Survival Rate of Intrahepatic Cholangiocarcinoma Patients after Surgical Treatment in Thailand

Sriputtha¹,

Khuntikeo²,

Promthet³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Intrahepatic cholangiocarcinoma (ICC), one of the primary liver cancers, is frequent in the northeastern part of Thailand. Surgical resection remains the best method of treatment, but patients suffering from ICC usually present at a late stage of the disease. Studies of survival and prognostic factors after surgery remain rare. The aim here was to evaluate the survival rate and factors affecting the survival of patients with intrahepatic cholangiocarcinoma after surgery. The study used a retrospective cohort design. The subjects were 73 consecutive patients with ICC, who were admitted for surgery to Srinagarind Hospital, Khon Kaen University, during the period 2005-2009. The censoring date was 31 December, 2011, data being evaluated using uni-and multivariate analyses. Postoperative survival analysis was performed by the Kaplan-Meier method, and the Cox proportional hazard model was used to identify independent prognostic factors. The total follow-up time was 99 person-years. The total number of deaths was 59, giving a mortality rate of 59 per 100 person-years. The cumulative 1-, 3-, and 5-year survival rates were 52.1%, 21.7%, and 11.2%, respectively. The median duration of survival after resection was 12.4 months. Univariate analysis revealed stage of disease, lymph node metastasis, histological type, histological grade and macroscopic classification to be statistically significant (p-value<0.05) prognostic factors. In the multivariate analysis, only macroscopic classification was statistically significant (p-value<0.05). In conclusion, macroscopic classification was the only independent factor found to be significantly associated with survival following surgical treatment of ICC.

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Section: Discussioncontrasting

confidence: 65%

“…The results of the present study are in line with the 1-and 3-year rates in these reviews, but the 5-year rates in the previous studies were generally higher. In recent studies (Cho et al, 2010;Ribero et al, 2012) the 1-and 3-year rates were also higher.…”

Section: Discussionmentioning

confidence: 82%

Survival Rate of Intrahepatic Cholangiocarcinoma Patients after Surgical Treatment in Thailand

Sriputtha¹,

Khuntikeo²,

Promthet³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Repeat hepatectomy is limited by poor remnant liver function or multifocal recurrence. In addition to that, technical and anatomical difficulties make repeat hepatectomy less feasible and more difficult to perform than initial hepatectomy [29,31].…”

Section: Discussionmentioning

confidence: 99%

Percutaneous ultrasound-guided thermal ablation for intrahepatic cholangiocarcinoma

Y²,

Lu³

et al. 2012

The British Journal of Radiology

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Objective: The objective of this study was to evaluate the treatment efficacy and overall survival (OS) of percutaneous ultrasound-guided thermal ablation by means of microwave ablation or radiofrequency ablation for intrahepatic cholangiocarcinoma (ICC). Methods: 18 patients with 25 ICC nodules underwent ultrasound-guided thermal ablation with curative intention. 8 patients were primary cases and 10 were recurrent cases after curative resection. The local treatment response, complications and survivals were analysed. Results: Complete ablation was achieved in 23 (92.0%, 23/25) nodules (diameter, 0.7-4.3 cm; mean, 2.5¡0.9 cm) and incomplete ablation was found in 2 (8.0%, 2/25) larger tumours (6.4 and 6.9 cm in diameter). No death associated with the treatment was found. The major complication rate was 5.5% (1/18). The follow-up periods ranged from 1.3 to 86.2 months (mean, 20.5¡26.3 months; median, 8.7 months). OS rates for all patients at 6, 12, 36 and 60 months were 66.7%, 36.3%, 30.3% and 30.3%, respectively. By univariate analysis, the patient source (primary or recurrent case) was found to be a significant prognostic factor for OS rates (p50.001). The patient source (p50.001) and the number of nodules (p50.038) were found to be significant prognostic factors for recurrence-free survival. OS rates for the primary ICC at 6, 12, 36 and 60 months were 87.5%, 75.0%, 62.5% and 62.5%, respectively. Conclusion: Percutaneous ultrasound-guided thermal ablation is a safe and effective therapeutic technique for ICC. Acceptable survival can be achieved in primary ICCs, whereas the prognosis of recurrent ICCs is relatively poor.

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“…Previous studies of survival in CCA patients have focused on specific subgroups-such as those at advanced stage (Park et al, 2009), receiving surgical resection (Murakami et al, 2011;Pattanathien et al, 2013;Sriputtha et al, 2013) or adjuvant therapy (Knüppel et al, 2012), or specific tumour locations (Cheng et al, 2007;Hasegawa et al, 2007;Nakagohri et al, 2008;Guglielmi et al, 2009;Bunsiripaiboon et al, 2010;Cho et al, 2010;Nuzzo et al, 2010;Li et al, 2011). In addition, most studies were retrospective, only one prospective study (Mihalache et al, 2010) has been reported, and there are none from Asian countries.…”

Section: Introductionmentioning

confidence: 99%

Factors Affecting Survival Time of Cholangiocarcinoma Patients: A Prospective Study in Northeast Thailand

Woradet¹,

Promthet²,

Songserm³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Survival Analysis of Intrahepatic Cholangiocarcinoma After Resection

Abstract: Preoperative CA19-9 level was a valuable clinical factor for predicting histopathologic invasiveness as well as clinical outcome. An adequate resection margin was the only modifiable factor by a surgeon during hepatic resection for ICC.

Cited by 123 publications

References 28 publications

Survival Rate of Intrahepatic Cholangiocarcinoma Patients after Surgical Treatment in Thailand

Survival Rate of Intrahepatic Cholangiocarcinoma Patients after Surgical Treatment in Thailand

Percutaneous ultrasound-guided thermal ablation for intrahepatic cholangiocarcinoma

Factors Affecting Survival Time of Cholangiocarcinoma Patients: A Prospective Study in Northeast Thailand

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