Survival Analysis of HIV/AIDS Patients Under ART Follow up in Attat Referral Hospital

Abstract

Background: The non-curable HIV/AIDS epidemic has become a serious health and development problem especially for developing country like Ethiopia despite using ART treatment. The antiretroviral treatment (ART) scale-up service has been a recent development in Ethiopia, but its impact on mortality has not been well investigated. This study aimed to analyze the survival time of HIV-positive patients under antiretroviral therapy (ART) and identifies associated risk factors in Attat Referral Hospital. Methods: A retrospective study was conducted to examine the survival of HIV/AIDS patients under ART at Attat Referral Hospitals. Total of 408 HIV/AIDS patients in ART from April 30, 2010 up to March 30, 2017 were included in the study. Cox proportional hazard model was employed to assess the survival of HIV/AIDS patients and the associated factors. Results: A total of 408 patients were followed for a survival mean time of 46 months. In the followed-up period, 121 (29.7%) patients dead and 287 (70.3%) patients were censored. Based on functional status of patients, higher mortality was significantly associated with bedridden (HR: 3.934) and Ambulatory (HR: 1.790). According to WHO stages the patients under ART follow up with stage-IV (HR: 7.277), stage-III (HR: 4.536) and stage-II (HR: 2.213) were high risk of dying than patients in stages-I and male patients are at high risk of death than females. Conclusions: This study found that the survival time of the HIV patient under ART follow-ups in Attat Referral Hospital of Guraghe zone was significantly associated with factors: functional status, Weight, Original Regimen, CD4 count and WHO stage.

Incidence of Mortality and Its Predictors Among Adult Human Immune Virus Infected Patients on Antiretroviral Therapy in Wolaita Sodo University Comprehensive Specialized Hospital, Southern Ethiopia: A Retrospective Follow-Up Study

“…27 In contrast to this, our study finding was higher than the study conducted from six Asia-Pacific countries that reported lower death rate of 5.3%, 23 in India of 2% 28 and in Europe of 4.7%. 27 However, our study finding is lower than a collaborative follow-up study conducted in South Africa which revealed 16.6% 27 and 29.7% death rate was reported at Attat Referral Hospitals, Gurage Zone, Ethiopia 10 as well as 16% in Illubabor and Buno-bedele zone. 8 This might be due to an improved care of opportunistic infections at facilities and the way of lifestyle that directly or indirectly affect the health seeking behavior of the patients.…”

“…Data collection format was prepared in English version by reviewing from the national ART intake and follow-up forms and different similarly literatures. 9,10,13,16 Socio demographic data (marital status, sex, age, occupation, residence, and educational status), baseline data, and laboratory data were collected by reviewing pre-ART registers (like sociodemographic data), ART intake forms, laboratory requests, individual patient's folder and monthly follow-up charts by experienced data collectors and daily activities of data collection team evaluated by principal investigators. The most recent laboratory test before initiation of ART was used as a baseline data.…”

“…However, there is a continuation of HIV related mortality with the use of ART. 10 Although a number of countries at a national level were working on track to achieve the 90-90-90 target by 2020, there is still 31% and 39% of unmet need for ART coverage and viral load suppression respectively in late 2017. 11 Although a recent and institutionalbased survey indicated several individuals were living with HIV, the estimated prevalence of HIV/AIDS in Sodo town was more than 0.84% in the last few years which is significant and the town was one of list high burden (geographical prioritized) among 100 districts in Ethiopia.…”