Survival Analysis of Cervical Cancer Patients: A Case Study of Bhutan

Tshewang, Ugyen; Satiracoo, Pairote; Lenbury, Yongwimon

doi:10.31557/apjcp.2021.22.9.2987

Cited by 8 publications

(7 citation statements)

References 20 publications

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“…This nding is consistent with the ndings of a study done in America among non-Hispanic African American and white women, which reported a 14.2% death rate and a 13.3% review of LMIC, but more than the 5.49% found in urban China studies [5] and the two studies conducted in USA 7.9-11.9% and 4% respectively [36]. However our nding is less than review conducted in Thailand Bhutan 22.7% [37] and interventional study done in India which reports 25.32% died in the chemotherapy plus surgery group and 25.24% died in the concomitant chemotherapy plus radiotherapy group [38]. The reasons of this variation might be the difference between study design, characteristics of study population, treatment modalities and sociodemographic characteristics of the patients.…”

Section: Discussionsupporting

confidence: 91%

Common Predictors of cervical cancer related mortality in Ethiopia. A systematic review and Meta-analysis

Hambisa,

Asfaha,

Ambisa

et al. 2023

Preprint

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Background Cervical cancer is caused by oncogenic subtypes of the human papillomavirus for 7.5% of all women cancer deaths worldwide; peaking between the ages of 35 and 65, and not only kills young women but also makes orphan children. Objective This review was intended to measure national level magnitude and the most common predictors of cervical cancer related mortality in Ethiopia. Methods Common Public databases like Science Direct, Embase, the Cochrane Library, and PubMed were thoroughly searched. The STATA 14 and Rev-Manager 5.3 statistical software packages were used for analysis, as well as a standardized data abstraction tool created in Microsoft Excel. The Cochrane Q-test statistics and the I2 test were used to assess non-uniformity. The pooled magnitude and predictors of cervical cancer related mortality were estimated using fixed-effect and random-effect models, respectively. Result The pooled mortality among cervical cancer patients was estimated that 16.39% at 95% confidence level fall in 13.89–18.88% in Ethiopia. The most common predictors of cervical cancer related mortality were late diagnosed, radiation therapy alone, and Being anemic were identified by this review. Among cervical cancer treatment modalities effectiveness of surgery with adjuvant therapy was also approved in this meta-analysis. Conclusion and recommendation: When compared to other countries, significant cervical cancer-related mortality was reported. Encouragement of cervical cancer screening at the national level for early diagnosis, anaemia detection, and treatment during anticancer initiation, as well as combination therapy, is critical to improving cervical cancer patient survival and decreasing mortality rates.

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Section: Discussionsupporting

confidence: 91%

Common Predictors of cervical cancer related mortality in Ethiopia. A systematic review and Meta-analysis

Hambisa,

Asfaha,

Ambisa

et al. 2023

Preprint

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show abstract

“…This finding is consistent with the findings of a study done in America among non-Hispanic African American and white women, which reported a 14.2% death rate and a 13.3% review of LMIC, but more than the 5.49% found in urban China studies [ 5 ] and the two studies conducted in USA 7.9–11.9% and 4% respectively [ 35 ]. However our finding is less than review conducted in Thailand Bhutan 22.7% [ 36 ] and interventional study done in India which reports 25.32% died in the chemotherapy plus surgery group and 25.24% died in the concomitant chemotherapy plus radiotherapy group [ 37 ]. The reasons of this variation might be the difference between study design, characteristics of study population, treatment modalities and sociodemographic characteristics of the patients.…”

Section: Discussioncontrasting

confidence: 78%

Common predictors of cervical cancer related mortality in Ethiopia. A systematic review and meta-analysis

Hambisa,

Asfaha,

Ambisa

et al. 2024

BMC Public Health

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Background Cervical cancer accounts for 7.5% of all female cancer related deaths worldwide; peaking between the ages of 35 and 65, and not only kills young women but also destroys families with young children. Objective This review was intended to measure national level magnitude and the most common predictors of cervical cancer related mortality in Ethiopia. Methods Common Public databases like Science Direct, Embase, the Cochrane Library, and PubMed were thoroughly searched. The STATA 14 and Rev-Manager 5.3 statistical software packages were used for analysis, as well as a standardized data abstraction tool created in Microsoft Excel. The Cochrane Q-test statistics and the I2 test were used to assess non-uniformity. The pooled magnitude and predictors of cervical cancer related mortality were estimated using fixed-effect and random-effect models, respectively. Result The pooled mortality among cervical cancer patients was estimated that 16.39% at 95% confidence level fall in 13.89–18.88% in Ethiopia. The most common predictors of cervical cancer related mortality were late diagnosed, radiation therapy alone, and Being anemic were identified by this review. Among cervical cancer treatment modalities effectiveness of surgery with adjuvant therapy was also approved in this meta-analysis. Conclusion and recommendation In this study high cervical cancer-related mortality was reported as compared to national strategies to alleviate cervical cancer related mortality. Advanced implementation of cervical cancer screening at the national level for early diagnosis, anaemia detection, and combination anticancer therapy during initiation, as well as combination therapy, is critical to improve cervical cancer patient survival and decreasing mortality rates.

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“…This finding was similar to the results reported in a study by Quinn et al on women with cervical cancer from 1973 to 2015 in the United States ( 13 ). In addition, other studies have confirmed the age of disease diagnosis as a predictor of survival in cervical cancer ( 8 , 14 ). Hence screening and diagnosis of the disease at a younger age are recommended.…”

Section: Discussionmentioning

confidence: 79%

Factors Affecting Survival of Patients with Cervical Cancer

Hasankhani,

Jahani,

Bazrafshan

et al. 2023

ijph

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Background: Cervical cancer is the fourth leading cause of cancer-related death among women worldwide. We aimed to identify the factors affecting the survival rate of cervical cancer patients, as these factors are vital for preventing the progression and effective treatment of cancer. Methods: In this retrospective cohort study, 254 patients with cervical cancer who were registered in The Kerman Population-Based Cancer Registry (KPBCR) between 2012 and 2022 and whose status was known to be alive or dead were enrolled. Since the proportional hazard assumption was not established for the type of treatment, the extended Cox model was used to determine the variables influencing the survival of the patients. Results: The mean survival time of the patients was 91.28 ± 3.02 months. The results of fitting the extended Cox model showed that the risk of death increases by 1.02 per year of age at diagnosis (HR=1.02; 95% CI: 1.00, 1.04). Moreover, for a one-unit increase in body mass index (BMI), the risk of death increased by 0.93 (HR=0.93; 95% CI: 0.88, 0.98). The risk of death in patients with disease stages III&IV was 3.08 times that of patients with disease stages I&II (HR=3.08; 95% CI: 1.05, 9.03). The risk of death in patients receiving at least one of the radiotherapy and chemotherapy treatments after 18 months was 7.11 times that of patients undergoing surgery (HR=7.11; 95% CI: 1.69, 29.91). Conclusion: The age of diagnosis, BMI, disease stage, and type of treatment significantly affect the survival of patients. Thus, raising women's awareness of periodical examinations and early diagnosis can reduce the risk of death and prevent cervical cancer progression.

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Survival Analysis of Cervical Cancer Patients: A Case Study of Bhutan

Cited by 8 publications

References 20 publications

Common Predictors of cervical cancer related mortality in Ethiopia. A systematic review and Meta-analysis

Common Predictors of cervical cancer related mortality in Ethiopia. A systematic review and Meta-analysis

Common predictors of cervical cancer related mortality in Ethiopia. A systematic review and meta-analysis

Factors Affecting Survival of Patients with Cervical Cancer

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