Survival after transfusion as assessed in a large multistate US cohort

Abstract

These data from the mid 1990s can be used in models of the effectiveness of risk reduction interventions and in models of the disease consequences of infections transmitted through blood transfusions.

Long‐term survival rate of pediatric patients after blood transfusion

“…Relatively few pediatric patients were included in the studies on which these probabilities were determined and none specifically analyzed data and factors associated with survival in children. Six of the studies reported survival rates after transfusion with population‐based data 2,3,5‐8 . Whyte 3 reported PTSR for all patients transfused over a 40‐day period in Canterbury, New Zealand, in 1984; there were 38 patients 19 years of age or younger of whom 35 of 38 (92%) were alive at 24 months after transfusion.…”

“…Of the six population‐based studies, this latter is the most informative with respect to PTSR in pediatric patients. No further analysis specific to pediatric patients was performed; however, Kleinman and coworkers 7 with a managed care administrative claims database covering 20 states identified 6960 patients who received transfusions in 1995 of which 6779 were included in their study. Their results show a PTSR of 69 percent at 1 year, 60 percent at 2 years, and 46 percent at 5 years.…”

“…Several studies reporting data on long‐term PTSR derived from population‐based studies or lookback investigations have been published 1‐8 . The large majority of patients in these studies were adults, however.…”

Improved hepatitis C treatment response in younger patients: findings from the UK HCV National Register cohort study

“…This does not reflect the pattern of HCV acquisition in the UK, where most infections are acquired via injecting drug use [3]. As transfusion recipients are more likely to have co-morbidity [30, 31] and patients with a history of injecting drug use are likely to differ in other important ways, including alcohol use, this may limit general application of the findings [30, 31]. …”

Too much, too little, too soon, too late? Transfusion and long‐term survival in children

“…Historical perspectives are useful in providing context in caring for patients, which is why long‐term follow‐up studies are so valuable 2,3 . The patient profiles of transfused pediatric patients have not changed dramatically.…”