Survival after relapse in children with solid tumors: A follow‐up study from the Italian off‐therapy registry

Ceschel, S.; Casotto, Veronica; Valsecchi, Maria Grazia; Tamaro, Paolo; Jankovic, Momcilo; Hanau, Guia; Fossati, Franca; Pillon, Marta; Rondelli, Roberto; Sandri, Alessandro; Silvestri, Daniela; Haupt, Riccardo; Cuttini, Marina

doi:10.1002/pbc.20726

Cited by 34 publications

(28 citation statements)

References 24 publications

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“…1) [11,16,79,81,87,88,90]. More specifically, HSC transplants, alone or in combination therapy, may be used for the treatment of patients with autoimmune diseases, refractory and severe aplastic anemias, congenital thrombocytopenia, osteoporosis, cardiovascular disorders, chronic inflammatory Bowel disorders (IBD) including Crohn's disease and ulcerative colitis, diabetes mellitus, leukemias, multiple myelanomas and Hodgkin's and non-Hodgkin's lymphomas and aggressive tumors [1,2,11,16,[57][58][59][60][93][94][95][96][97]. It has also been reported that MSCs, EPCs and their progenies can contribute to the regenerative process of several tissues including bone, cartilage, tendon, muscle, adipose, brain, lung, heart, pancreas, kidney and eye [98,99].…”

Section: Therapeutic Applications Of Bm-derived Stem/progenitor Cellsmentioning

confidence: 99%

Recent Progress on Tissue-Resident Adult Stem Cell Biology and Their Therapeutic Implications

2008

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Recent progress in the field of the stem cell research has given new hopes to treat and even cure diverse degenerative disorders and incurable diseases in human. Particularly, the identification of a rare population of adult stem cells in the most tissues/organs in human has emerged as an attractive source of multipotent stem/progenitor cells for cell replacement-based therapies and tissue engineering in regenerative medicine. The tissue-resident adult stem/progenitor cells offer the possibility to stimulate their in vivo differentiation or to use their ex vivo expanded progenies for cell replacement-based therapies with multiple applications in human. Among the human diseases that could be treated by the stem cell-based therapies, there are hematopoietic and immune disorders, multiple degenerative disorders, such as Parkinson's and Alzeimeher's diseases, type 1 or 2 diabetes mellitus as well as eye, liver, lung, skin and cardiovascular disorders and aggressive and metastatic cancers. In addition, the genetically-modified adult stem/progenitor cells could also be used as delivery system for expressing the therapeutic molecules in specific damaged areas of different tissues. Recent advances in cancer stem/progenitor cell research also offer the possibility to targeting these undifferentiated and malignant cells that provide critical functions in cancer initiation and progression and disease relapse for treating the patients diagnosed with the advanced and metastatic cancers which remain incurable in the clinics with the current therapies.

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Section: Therapeutic Applications Of Bm-derived Stem/progenitor Cellsmentioning

confidence: 99%

Recent Progress on Tissue-Resident Adult Stem Cell Biology and Their Therapeutic Implications

2008

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“…The clinical course of NB is influenced by several factors and among these disease stage plays an important role: patients with stage 1 and 2 will tend to have an excellent prognosis, with rates of 5-year disease-free survival (DFS), respectively, of 90 and 85 %, while those with stage 3 and 4 will have a poor prognosis, with rates of 40-60 and 15-25 %, respectively [5][6][7]. In this context, imaging modalities become determinant for a proper assessment of disease extension.…”

Section: Diagnostic Contextmentioning

confidence: 99%

Potential role of 18F-DOPA PET in neuroblastoma

Piccardo

Lopci

2016

Clin Transl Imaging

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18 F-3,4-Dihydroxyphenylalanine (DOPA) is the radio-labelled analogue of DOPA, a precursor of dopamine and catecholamines. It is a multivalent molecule that is widely used for functional imaging of various neural crest tumors, documenting a better diagnostic accuracy compared to 123 I-metaiodobenzylguanidine ( 123 I-mIBG) scintigraphy and other conventional imaging modalities. Neuroblastoma (NB) is an embryonic tumor deriving from the peripheral sympathetic nervous system, commonly included into the vast group of neural crest tumors. So, it maintains the ability to produce and release biologically active amines and in most cases is characterized by an increased metabolism of catecholamines. 123

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“…Further treatment is available in phase I and phase II clinical trials that test new agents and combinations of agents against neuroblastoma, but the outcome remains very poor for relapsed high-risk disease. [21] Case Report: A 7 years old girl was admitted to the Dept of ENT & Head Neck Surgery, Dhaka Medical College Hospital with bilateral, non-tender, hard mass in the neck for 3 months with evening rise of temperature, without any sweating or chills. She had no complaints of pain, no bleeding, no wt.…”

Section: Neuroblastoma Neck In a 7-year-old Girl: A Very Rare Presentmentioning

confidence: 99%

Neuroblastoma neck in a 7-year-old girl: a very rare presentation

Shah

Rumi

2015

J. paediatr. surg. Bangladesh

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Abstract:Neuroblastoma in neck is a very rare presentation. The age range of neuroblastoma is broad, but only 10% of cases are reported in people older than 5years of age, and is most commonly diagnosed in children before age of 5years (with highest incidence in the first year of life), being slightly more common in boys. The girl child reported in our case, being mere 7 years old, presented with bilateral hard neck swellings, was not clinically suspected of this rare presentation, until Immunohistochemistry confirmed the diagnosis. This report underscores the need for prompt evaluation of patients (especially children) with common symptoms and uncommon presentation of the disease entity.

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Survival after relapse in children with solid tumors: A follow‐up study from the Italian off‐therapy registry

Abstract: Overall, patients with solid tumors who relapse after treatment discontinuation have a poor outcome, but significant differences exist according to the tumor types.

Cited by 34 publications

References 24 publications

Recent Progress on Tissue-Resident Adult Stem Cell Biology and Their Therapeutic Implications

Recent Progress on Tissue-Resident Adult Stem Cell Biology and Their Therapeutic Implications

Potential role of 18F-DOPA PET in neuroblastoma

Neuroblastoma neck in a 7-year-old girl: a very rare presentation

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