Survival after lung transplant for coal workers’ pneumoconiosis

Enfield, Kyle B.; Floyd, Shawn; Barker, B A; Weder, Max; Kozower, Benjamin D.; Jones, David R.; Lau, Christine L.

doi:10.1016/j.healun.2012.09.002

Cited by 14 publications

(17 citation statements)

References 7 publications

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“…Hayes and colleagues identified eight cases of lung transplantation for CWP in Kentucky and reported good clinical outcomes and survivability post transplantation [Hayes et al, 2012]. In contrast, Enfield and colleagues examined data for 30 recipients determined to have CWP and reported lower survival compared to patients undergoing lung transplants for COPD, silicosis, and idiopathic pulmonary fibrosis [Enfield et al, 2012]. …”

Section: Discussionmentioning

confidence: 99%

“…To be eligible for inclusion, patients must have had a primary diagnosis of CWP or pneumoconiosis unspecified and received a single or bilateral lung transplant in the U.S. during 1996–2014, because the first lung transplant for CWP was performed in 1996 [Enfield et al, 2012]. We describe the trend in lung transplantations for these patients, summarize recipient demographic and clinical characteristics, and estimate median survival using the Kaplan–Meier method.…”

Section: Methodsmentioning

confidence: 99%

“…Those with radiographic evidence of CWP should be advised to move to a less-dusty work environment, but this is not always possible, and disease can continue to progress even after cessation of coal mine dust exposure [Kimura et al, 2010; Mason et al, 2010]. Supportive therapies do not slow progression of CWP, and recent reports have described the use of lung transplantation among patients with end-stage CWP [Enfield et al, 2012; Hayes et al, 2012]. …”

Section: Introductionmentioning

confidence: 99%

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Lung transplantation is increasingly common among patients with coal workers’ pneumoconiosis

Blackley

Halldin

Cummings

et al. 2016

American J Industrial Med

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Background The prevalence of coal workers’ pneumoconiosis (CWP) in U.S. coal miners has increased, and severe presentations are increasingly common. Methods We describe trends in lung transplantation during 1996–2014 for recipients with a primary diagnosis of CWP or pneumoconiosis unspecified, and we summarize recipient characteristics and estimate survival. Results A total of 47 transplants were included; nearly three-quarters were performed during 2008–2014. All recipients were male, 96% were white, and the mean age was 56 years. Mean FEV1% was 35%; mean FVC% was 53%. Mean time on a waitlist was 155 days, and 60% of transplants were bilateral. Median survival was 3.7 years. Conclusions These transplants reflect the use of a scarce resource for an entirely preventable disease, and highlight the need for enhanced efforts to reduce coal mine dust exposures.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lung transplantation is increasingly common among patients with coal workers’ pneumoconiosis

Blackley

Halldin

Cummings

et al. 2016

American J Industrial Med

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“…In fact, the first case of lung transplantation for CWP in the United States documented in United Network of Organ Sharing data was reported in 1996. 34 Two reports published in 2012 evaluating lung transplantation for CWP reported somewhat different results. The experience in 143 patients undergoing unilateral or bilateral lung transplantation at the University of Kentucky was of generally good outcomes and comparable survivability versus other medical conditions.…”

Section: Treatment Of Cmdldmentioning

confidence: 99%

“…35 In contrast, other investigators observed shorter lung graft survivability compared with transplants for COPD, IPF, and silicosis. 36 Nevertheless, given the lack of other options for miners with CWP and end-stage lung disease, those caring for such miners who are appropriate candidates for transplantation should consider referring them for transplant evaluation.…”

Section: Treatment Of Cmdldmentioning

confidence: 99%

Respiratory Diseases Caused by Coal Mine Dust

Laney

Weissman

2014

Journal of Occupational &Amp; Environmental Medicine

143

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Objective To provide an update on respiratory diseases caused by coal mine dust. Methods This article presents the results of a literature review initially performed for an International Conference on Occupational and Environmental Lung Disease held in summer 2013. Results Coal mine dust causes a spectrum of lung diseases collectively termed coal mine dust lung disease (CMDLD). These include Coal Workers’ Pneumoconiosis, silicosis, mixed dust pneumoconiosis, dust-related diffuse fibrosis (which can be mistaken for idiopathic pulmonary fibrosis), and chronic obstructive pulmonary disease. CMDLD continues to be a problem in the United States, particularly in the central Appalachian region. Treatment of CMDLD is symptomatic. Those with end-stage disease are candidates for lung transplantation. Because CMDLD cannot be cured, prevention is critical. Conclusions Coal mine dust remains a relevant occupational hazard and miners remain at risk for CMDLD.

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