Survival After Cardiac Transplantation: Influence of the Previous Cardiopathy in the Recipient

Romero-Rodríguez, Nieves; Lage-Gallé, Ernesto; Guisado-Rasco, Agustín; Nevado-Portero, Jaime; Rodríguez, Rosario Oliva; Machuca, M. Gonzalez Vargas; Marquez, Misael; Martínez-Martínez, Ángel

doi:10.1016/j.transproceed.2010.06.009

Cited by 8 publications

(3 citation statements)

References 5 publications

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“…The search yielded 4,053 studies, with thirteen studies fulfilling the inclusion critieria, [11][12][15][16][17][18][19][20][21][22][23][24][25] (Figure 1) all retrospective, unmatched cohort studies. Nine single centre and four registry studies were included, consisting of 899 CHD and 43,452 non-CHD patients.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Outcomes in adult congenital heart disease patients undergoing heart transplantation: A systematic review and meta-analysis

Doumouras

Alba

Foroutan

et al. 2016

The Journal of Heart and Lung Transplantation

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Section: Study Selection and Characteristicsmentioning

confidence: 99%

Outcomes in adult congenital heart disease patients undergoing heart transplantation: A systematic review and meta-analysis

Doumouras

Alba

Foroutan

et al. 2016

The Journal of Heart and Lung Transplantation

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“…Previous investigations have shown that patients with ischemic cardiomyopathy undergoing HT have a significant presence of PVD and have a lower long-term survival rate compared with those with idiopathic cardiomyopathy, which could be related to the existence of cardiovascular risk factors that produced the cardiomyopathy originally. 16–18 This cardiovascular risk profile of ischemic cardiomyopathy transplant recipients might be associated with the overall vascular function after HT. Previous investigations have demonstrated that HT recipients with previous ischemic cardiomyopathy have a blunted vascular function during the first year after HT because of continued endothelial dysfunction and oxidative stress, which can lead to decrease long-term survival.…”

Section: Discussionmentioning

confidence: 99%

Effect of Peripheral Vascular Disease on Mortality in Cardiac Transplant Recipients (from the United Network of Organ Sharing Database)

Enciso

Kato

Jin

et al. 2014

The American Journal of Cardiology

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Peripheral vascular disease (PVD) portends increased morbidity and mortality in patients with heart failure. In those with advanced heart failure, heart transplantation (HT) is the only causative therapy to increase survival. However, little is known about the impact of symptomatic PVD on survival of HT recipients in large multicenter cohorts. The aim of this study was to investigate an association between recipient symptomatic PVD and survival after HT. We analyzed 20,297 patients from the United Network of Organ Sharing data set. Survival analysis using a control cohort established by propensity matching was performed. There was an increased prevalence of traditional cardiovascular risk factors in 711 patients with symptomatic PVD compared with 19,586 patients without PVD. Patients with pre-transplant symptomatic PVD had increased post-transplant mortality compared with those without PVD (1-, 5- and 10-year survival rate 91.5% vs 94.9%, 74.8% vs 82.6%, 48.6% vs 54.7%, respectively, log-rank p <0.001). On multivariate analysis based on the propensity matching, factors associated with a lower survival rate were presence of PVD (hazard ratio 1.20, 95% confidential interval 1.02 to 1.42, p = 0.030), and female gender (hazard ratio 1.22, 95% confidence interval 1.02 to 1.47, p = 0.034). In conclusion, patients with symptomatic PVD have a lower survival rate after HT. Symptomatic PVD should be considered an independent risk factor for poor prognosis in patients undergoing HT evaluation.

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“…Among adults, acute myocarditis accounted for approximately 1.6% of cardiac transplantations in a single-center review [94]. Mortality rate at 5 years after transplantation for previous myocarditis in adults was nearly 30%.…”

Section: Cardiac Transplantationmentioning

confidence: 99%

Acute myocarditis in children

Simpson

Canter

2011

Expert Review of Cardiovascular Therapy

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Myocarditis is an uncommon but significant disease in children. Diagnosis requires a high index of suspicion and understanding of the clinical presentation of this disease. The understanding of the mechanisms of disease-host immune response and host response has improved, but is not completely known. Therapy remains mainly supportive, while the use of immunotherapy in children is still controversial. The majority of children will improve; however, a substantial portion of children will die or develop persistent dilated cardiomyopathy leading to necessary heart transplantation.

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Survival After Cardiac Transplantation: Influence of the Previous Cardiopathy in the Recipient

Cited by 8 publications

References 5 publications

Outcomes in adult congenital heart disease patients undergoing heart transplantation: A systematic review and meta-analysis

Outcomes in adult congenital heart disease patients undergoing heart transplantation: A systematic review and meta-analysis

Effect of Peripheral Vascular Disease on Mortality in Cardiac Transplant Recipients (from the United Network of Organ Sharing Database)

Acute myocarditis in children

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