Survival After Cardiac Arrest in Hospital

Peatfield, Richard; Taylor, D. N.; Sillett, R. W.; McNicol, Martin W.

doi:10.1016/s0140-6736(77)92435-7

Cited by 163 publications

(18 citation statements)

References 17 publications

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“…Yet, there is little objective documentation that epinephrine improves meaningful survival. 27,28 Epinephrine increases the incidence of ventricular ectopy. 7,14 A larger number of electrical shocks are required for electrical defibrillation with return of spontaneous circulation after administration of epinephrine and with the adversity of significantly greater postresuscitation myocardial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Evidence Favoring the Use of an α ₂ -Selective Vasopressor Agent for Cardiopulmonary Resuscitation

et al. 2003

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Background-Both ␣ 1 -and ␤-adrenergic agonists increase the severity of global myocardial ischemic injury. We hypothesized that combined ␤-and ␣ 1 -adrenergic blockade would improve initial resuscitation and postresuscitation myocardial and neurological functions. We further hypothesized that the resulting ␣ 2 -actions of relatively brief duration would favor improved functions compared with the more prolonged effect of nonadrenergic vasopressin. Methods and Results-Three groups of 5 male domestic pigs weighing 37Ϯ3 kg were investigated. Ventricular fibrillation was untreated for 7 minutes before the start of precordial compression, mechanical ventilation, and attempted defibrillation. Animals were randomized to receive central venous injections of equipressor doses of (1) epinephrine, (2) epinephrine in which both ␣ 1 -and ␤-adrenergic effects were blocked by previous administration of prazosin and propranolol, and (3) vasopressin during CPR. All but 1 animal were successfully resuscitated. After injection of epinephrine, significantly better cardiac output and fractional area change, together with lesser increases in troponin I, were observed after ␣ 1 -and ␤-adrenergic blockade. Postresuscitation neurological function was also improved after ␣ 1 -and ␤-block in comparison with unblocked epinephrine and after vasopressin. Conclusions-Equipressor doses of epinephrine, epinephrine after ␣ 1 -and ␤-adrenergic blockade, and vasopressin were equally effective in restoring spontaneous circulation after prolonged ventricular fibrillation. However, combined ␣ 1 -and ␤-adrenergic blockade, which represented a predominantly selective ␣ 2 -vasopressor effect, resulted in improved postresuscitation cardiac and neurological recovery.

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Section: Discussionmentioning

confidence: 99%

Evidence Favoring the Use of an α ₂ -Selective Vasopressor Agent for Cardiopulmonary Resuscitation

et al. 2003

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“…6 Few studies have published long-term survival rates after successful in-hospital CPR and the results have been inconsistent. 4,[7][8][9] Moreover, no studies have examined factors that may affect survival among discharged patients who have been resuscitated during their hospital stay.…”

Section: Arch Internmentioning

confidence: 99%

Short- and Long-term Survival After Cardiopulmonary Resuscitation

Zoch¹,

Desbiens²,

DeStefano³

et al. 2000

Arch Intern Med

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“…1 There have been a number of studies after that, which have reported outcome and the predictors affecting outcome. [2][3][4][5] Cardiopulmonary resuscitation is a frequently performed medical intervention in healthcare facilities. Successful cardiopulmonary resuscitation after in-hospital cardiac arrest depends on basic and advanced life support systems, the ability to immediately defibrillate the arrested heart, and the quality of the CPR intervention (Beuret et al; Jorgenson 1997).…”

Section: Introductionmentioning

confidence: 99%

Outcomes of in-hospital, out of intensive care and operation theatre cardiac arrests in a tertiary referral hospital

Chakravarthy

Mitra

Nonis

2012

Indian Heart Journal

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Objective: Cardiac arrest in the hospital wards may not receive as much attention as it does in the operation theatre and intensive care unit (ICU). The experience and the qualifications of personnel in the ward may not be comparable to those in the other vital areas of the hospital. The outcome of cardiac arrest from the ward areas is a reasonable surrogate of training of the ward nurses and technicians in cardiopulmonary resuscitation. We conducted an audit to assess the issues surrounding the resuscitation of cardiac arrest in areas other than operation theatre and ICU in a tertiary referral hospital. Aims of the audit:To assess the outcomes of cardiac arrest in a tertiary referral hospital. Areas such as wards, dialysis room and emergency room were considered for the audit.Methods: This is a retrospective observational audit of the case records of all the adult patients who were resuscitated from 'code blue'. Data for 2 years from 2007 was analysed by a research fellow unconnected with the resuscitations.Results: Twenty-two thousand three hundred and forty-four patients were admitted as in-patients to the hospital during the 2 years, starting May 2007 through May 2009. One hundred code blue calls were received during this time. Twenty-two of the total calls received were false. Among the 78 confirmed cardiac arrests 69 occurred in the wards, 2 in emergency room, 1 in cardiac catheterisation laboratory and 3 in dialysis room. Twenty-eight patients were declared dead after unsuccessful cardiopulmonary resuscitation. Among the 50 who were resuscitated with a return of spontaneous rhythm 26 died. Twenty-four patients were discharged (survival rate of 30%). The survival decreased significantly as the age progressed beyond 60. The resuscitation rates were better in day shifts in contrast to the night. Higher survival was noted in patients who received resuscitation in less than a minute. Conclusion:A overall survival to discharge rate of 30% was noted in this audit. Higher survival rates might be attributable to high rate and degree of training at the time of their employment, which was repeated at yearly interval.

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Survival After Cardiac Arrest in Hospital

Cited by 163 publications

References 17 publications

Evidence Favoring the Use of an α ₂ -Selective Vasopressor Agent for Cardiopulmonary Resuscitation

Evidence Favoring the Use of an α ₂ -Selective Vasopressor Agent for Cardiopulmonary Resuscitation

Short- and Long-term Survival After Cardiopulmonary Resuscitation

Outcomes of in-hospital, out of intensive care and operation theatre cardiac arrests in a tertiary referral hospital

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Survival After Cardiac Arrest in Hospital

Cited by 163 publications

References 17 publications

Evidence Favoring the Use of an α 2 -Selective Vasopressor Agent for Cardiopulmonary Resuscitation

Evidence Favoring the Use of an α 2 -Selective Vasopressor Agent for Cardiopulmonary Resuscitation

Short- and Long-term Survival After Cardiopulmonary Resuscitation

Outcomes of in-hospital, out of intensive care and operation theatre cardiac arrests in a tertiary referral hospital

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Product

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Evidence Favoring the Use of an α ₂ -Selective Vasopressor Agent for Cardiopulmonary Resuscitation

Evidence Favoring the Use of an α ₂ -Selective Vasopressor Agent for Cardiopulmonary Resuscitation