Survival after Aluminum Phosphide Poisoning in Pregnancy

Lahlou, Adnane; Sidayne, Mohammed; Benlamkaddem, Said; Berdaï, Mohamed Adnane; Harandou, Mustapha

doi:10.1155/2020/2785425

Cited by 1 publication

(2 citation statements)

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“…Because phosphine gas directly affects the myocardium, the major lethal effect of aluminum phosphide typically manifests as a cardiovascular disorder and arrhythmia. 4 Phosphine gas has a density of 1.52 grams per liter, a molecular weight of 34, is colorless, flammable, and smells like rotting fish. The presence of impurities like diphosphine (P 2 H 4 ), methane, arsenic, phosphine, and hydrogen released from it is what gives it its odor.…”

Section: Introductionmentioning

confidence: 99%

“…The presence of impurities like diphosphine (P 2 H 4 ), methane, arsenic, phosphine, and hydrogen released from it is what gives it its odor. ALP poisoning is associated with a high death rate in the first 24-48 hours 4 and there is no known antidote for treatment. ALP poisoning, in general, is among the most frequent causes of poisoning-related deaths in many nations, particularly developing nations.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the effect of N-acetylcysteine on aluminum phosphide toxicity in rats

et al. 2022

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Aluminum Phosphide (ALP) is one of the most dangerous pesticides. When it comes into contact with water, it emits Phosphine (PH3) gas, which causes poisoning and death in many people. The purpose of this study is to look into the role of N-acetylcysteine in the treatment of aluminum phosphide toxicity in rats. In this study, 30 male Wistar rats were fed with aluminum phosphide orally. After 15 minutes, N-acetylcysteine was administered intraperitoneally. The antioxidant enzymes glutathione S-Transferase (GST), Superoxide Dismutase (SOD), Catalase (CAT), glutathione (GSH), Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), and Alkaline Phosphatase (ALK) were studied in blood plasma. CAT, GST, and GSH concentrations in plasma, liver, and kidneys of rats infected with aluminum phosphide decreased, while AST, ALT, and ALK concentrations increased. The levels of all enzymes studied approached normal after N-acetylcysteine administration, and the rats survived for up to 12-15 hours. According to the findings of this study, N-acetylcysteine (NAC) at a dose of 10 mg/kg improves hepatic manifestations and prevents liver necrosis, so it can be considered a potential therapeutic agent in the treatment of this poisoning.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%