Surveys of workers occupationally exposed to PCBs and of yusho patients.

Abstract

Surveys of workers occupationally exposed to polychlorinated biphenyls (PCBs) in the production of thread or of paint, and of yusho patients were carried out from 1973 to 1982. PCB concentrations in the plasma of the workers ranged from 2 to 521 ppb, and some showed higher PCB levels in the plasma than typical Japanese yusho patients. Gas chromatographic patterns of plasma PCBs of the workers with high PCB levels were shown to match the patterns of the PCBs to which they had been exposed in the workplace. Japanese yusho children showed remarkable decrease with time, but no such decrease was observed in the yusho adults and the workers. Polychlorinated quaterphenyls (PCQs) were detected in the blood of typical Japanese and Taiwanese yusho patients, but PCQ levels in the plasma of the workers were below the detection limit of 0.02 ppb. Clinical findings and subjective complaints of the workers were usually slight compared with typical yusho patients, though some of them had mild dermal manifestations and their PCB levels were suspected to be related to serum triglyceride values. On the basis of these results, we discussed the relationship between the health status of the subjects and their contamination with PCBs or related compounds.

Toxicology, Structure-Function Relationship, and Human and Environmental Health Impacts of Polychlorinated Biphenyls: Progress and Problems

“…The human health effects of PCBs have been reviewed (45,(107)(108)(109)(110). Exposure of humans to relatively high levels of PCBs has occurred primarily in individuals working in plants that extensively used PCBs and PCB-containing equipment.…”

Structure-activity relationships for interactions of hydroxylated polychlorinated biphenyls with human hydroxysteroid sulfotransferase hSULT2A1

“…Symptoms ranging from elevated serum lipid levels, increased levels of serum enzymes, possible hepatic damage, respiratory problems, chloracne, and related dermal lesions have been observed in individuals who worked in plants where they were exposed to PCBs (5). According to one study, when blood plasma PCBs levels of exposed workers in Japan were tested, and compared to plasma PCB levels of the Yusho patients, the workers had considerably higher PCB levels (16). Furthermore, PCB levels in blood and breast milk of mothers who were capacitor workers in Japan were more elevated than those who were not exposed to PCBs (15).…”