“…Although Y. lipolytica present two main drawbacks since it accumulates limited amounts of lipids (Beopoulos et al, 2009a) and it cannot consume some preferred substrates such as lignocellulosic biomass or starch, it has been metabolically engineered to overcome these issues. On the one hand, among many engineering approaches (Dulermo and Nicaud, 2011;Liu et al, 2015b;Liu et al, 2015c;Tai and Stephanopoulos, 2013), Blazeck et al (Blazeck et al, 2014) rewired lipogenesis generating a strain able to accumulate up to 90% of its DCW as lipids and Qiao et al (Qiao et al, 2015) engineered Yarrowia and reached 85% of the theoretical maximal yield. On the other hand, several groups have tuned its lipid metabolism to make it able to produce lipids from raw starch (Ledesma-Amaro et al, 2015), cellulose (Wei et al, 2014), cellobiose (Guo et al, 2015), fructose (Lazar et al, 2014) and lignocellulosic material (Tsigie et al, 2011).…”