Survey On Methanol Poisoning Epidemic in Rafsanjan City in Year 2013

Abstract

Background: Examination and early detection of the methanol toxicity epidemic are very important, so identification and initiation of appropriate therapy can significantly reduce morbidity and mortality. Therefore, this study was aimed to investigation methanol poisoning epidemic in Rafsanjan city. Methods: This case series study was conducted in 252 patients with methanol poisoning in 2013 in the Ali-ibn-Abi-Talib hospital of Rafsanjan. Data were through interviews and records that were collected at hospital admission. Due to the large number of patients and the possible lack of ability of rapid measurement of serum levels of methanol and need of rapid intervention, treatment to reduce any further complications, early diagnosis and treatment were carried out by clinical history and interpretation of arterial blood gas test results. Data record on provided checklists and then analyzed using SPSS version 19. Results: The mean pH was 0.13±7.27. The most frequent clinical features were visual disturbances (39.7%), dyspnea (1.2%), and gastrointestinal symptoms (7.1%). There was a trend towards decreasing PCO2 with decreasing pH amongst the patients surviving. The opposite trend was demonstrated in the dying; the difference was highly significant by linear regression analyses (P< 0.001). Conclusions: Methanol poisoning still has a high morbidity and mortality, mainly because of late diagnosis and treatment. Respiratory arrest, coma and severe metabolic acidosis upon admission were strong predictors of poor outcome. Early admission and ability of respiratory compensation of metabolic acidosis were associated with survival.

Visual Disturbances in Patients With Acute Methanol Poisoning: A Cross-sectional Study

“…As per Mostafazadeh and Eghbali, 14.3% of patients encountered visual complications at discharge [7]. Mirzaei et al reported a prevalence of 39.7% for vision problems, i.e., mentioned as the most common complication [8]. However, in the study by Massoumi et al, 71% of the examined patients manifested nausea and vomiting.…”

“…Most patients with methanol poisoning manifest some clinical signs of ophthalmological abnormalities, even in the absence of visual dysfunction [5]. The prevalence of visual disturbances after methanol poisoning ranges from 29% to 64% [1,2,[6][7][8].…”