Survey of the eventual diagnosis in 600 cases referred for a second histological opinion after an initial biopsy diagnosis of Hodgkin's disease

Symmers, Senr W. St. C.

doi:10.1136/jcp.21.5.650

Cited by 62 publications

(5 citation statements)

References 4 publications

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“…The finding of seasonal variation in the incidence of the disease is consistent with, but does not prove an infectious agent as the precipitating factor of Hodgkin's disease. Several viral infections produce features of lymph nodes reminiscent of Hodgkin's disease [11]. Hence it has been proposed that the Reed-Sternberg cells may originate from virus-induced multinuclear giant cells by malignant transformation [12].…”

Section: Discussionmentioning

confidence: 99%

Detection of Mumps Virus Antigens in Hodgkin’s Disease Tissues

Truant¹,

Hallum²

1976

Oncology

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Mumps virus antigens were demonstrated in biopsied tissues from Hodgkin’s disease patients by indirect immunofluorescence. Impression smears from ten lymph node and two spleen specimens revealed viral antigens in the nucleus, cytoplasm or both. Measles virus antigens were detected in six out of seven Hodgkin’s disease tissues (lymph nodes) both in the nucleus and cytoplasm. All tissues tested for the presence of Newcastle diesease virus (NDV, an avian paramyxovirus) antigens were negative. Control tissues were obtained from patients with non-Hodgkin’s lymphomas, breast cancers, adenocarcinomas and a number of other disease processes. In control tissues mumps antigens were detected in seven out of 31 specimens and measles antigens in nine out of 18 tissues.

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Section: Discussionmentioning

confidence: 99%

Detection of Mumps Virus Antigens in Hodgkin’s Disease Tissues

Truant¹,

Hallum²

1976

Oncology

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“…Finally, tertiary syphilis develops with nodules, ulcers and gummata affecting various organs, including the nervous system 9 10. Luetic lymphadenitis, characterised by a painless and firm lymph node enlargement, is characteristic of primary (localised lymphadenopathy) and secondary (generalised lymphadenopathy), and possibly tertiary, syphilis 11 12. Primary lesions found most often are genital (85%) and anal (10%), but only rarely oropharyngeal 8…”

Section: Introductionmentioning

confidence: 99%

Oropharyngeal lesions and cervical lymphadenopathy: syphilis is a differential diagnosis that is still relevant

et al. 2010

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Syphilitic lymphadenitis is still a relevant differential diagnosis of cervical lymphadenopathy, and it is clinically often not suspected. Co-existing oropharyngeal lesions should alert the physician to this differential diagnosis; and lesions with compatible morphology should be tested with immunohistochemistry and immunocytochemistry and/or molecular analysis to confirm the diagnosis of syphilis.

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“…Indeed, information in medical records, even histopathological diagnoses, may sometimes be invalid (Saksela & Rintala, 1968;Symmers, 1968;Hakama et al, 1973;Sax6n, 1979;Gray et al, 1987;Ullin et al, 1990). Nevertheless, the reabstracted record method is regarded as the most objective way of evaluating the accuracy of cancer registration data (Parkin et al, 1992).…”

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confidence: 99%

How accurate are Scottish cancer registration data?

Brewster

Crichton²,

Muir³

1994

Br J Cancer

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SinaryIn order to assess the accuracy of Scottish cancer registration data, a random sample of 2,200 registrations, attributed to the year 1990, was generated. Relevant medical records were available for review in 2,021 (92%) cases. Registration details were reabstracted from available records and compared with data in the registry. Discreancies in identifying items of data (surname, forename, sex and date of birth) were found in 3.5% of cases. Most were trivial and would not disturb record linkage. Discrepancy rates of 7.1% in post code of residence at the time of diagnosis (excluding differences arising through boundary changes), 11.0% in anniversary date (excluding differences of 6 weeks or less), 7.7% in histological verification status, 5.4% in ICD-9 site codes (the first three digits) and 14.5% in ICD-O morphology codes (excluding 'inferred' morphology codes) were recorded. Overall, serious discrepancies were judged to have occurred in 2.8% of cases. In many respects, therefore, Scottish cancer registration data show a high level of accuracy that compares favourably to the reported accuracy of the few other cancer registries undertaking such analyses.

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Survey of the eventual diagnosis in 600 cases referred for a second histological opinion after an initial biopsy diagnosis of Hodgkin's disease

Cited by 62 publications

References 4 publications

Detection of Mumps Virus Antigens in Hodgkin’s Disease Tissues

Detection of Mumps Virus Antigens in Hodgkin’s Disease Tissues

Oropharyngeal lesions and cervical lymphadenopathy: syphilis is a differential diagnosis that is still relevant

How accurate are Scottish cancer registration data?

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