Survey of the Development of Laryngeal Epithelium

Tucker, John; Vidić, Branislav; Gf, Tucker; Stead, J. W.

doi:10.1177/00034894760850s501

Cited by 26 publications

(9 citation statements)

References 19 publications

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“…Furthermore, our OCT developmental analysis reveals that changes are mostly subepithelial. No significant growth is observed for the epithelial layer, which is analogous to histological findings between neonatal and adult EP 50 . However, the SLP shows a positive linear relationship between its thickness and age.…”

Section: Discussionsupporting

confidence: 77%

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Evaluation of the Human Vocal Fold Lamina Propria Development Using Optical Coherence Tomography

et al. 2021

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Objectives/Hypothesis Identifying distinctive features of the vocal fold (VF) during development could have significant clinical implications for treating voice disorders. This study investigates the structural organization of the VF microanatomy across gender and age groups using optical coherence tomography (OCT). Study Design Prospective clinical trial. Materials and Methods In vivo OCT images were acquired from 97 patients (58 males and 39 females) aged between 6 weeks and 27 years. All patients showed no signs of vocal fold pathology on endoscopy. Morphological features were extracted from OCT images and statistically compared between age groups. This study was performed at Massachusetts Eye and Ear between 2017 and 2019. Results All OCT acquisitions show a stratified microanatomy across age groups, even in newborns suggesting the presence of a superficial lamina propria (SLP) at birth. Furthermore, the optical scattering in the VF lamina propria changes according to age, suggesting subepithelial maturation. Although the epithelium thickness was relatively constant across age groups, the SLP showed a significant linear relationship between age and thickness (P = .016). Furthermore, a significant difference (P = .002) in SLP thickness was found between young adult males and females. The overall thickness of the entire mucosa did not change significantly with age. Conclusion OCT is a noninvasive imaging modality capable of providing quantitative morphological features to describe the VF development. A stratified structure can be observed in OCT from newborns to young adults. Further investigations could combine OCT, acoustic measurements, and molecular sensitive techniques to provide a complete interpretation of the VF development. Level of Evidence NA Laryngoscope, 131:E2558–E2565, 2021

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Section: Discussionsupporting

confidence: 77%

“…No significant growth is observed for the epithelial layer, which is analogous to histological findings between neonatal and adult EP. 50 However, the SLP shows a positive linear relationship between its thickness and age. It is 27% thicker in young adults than newborns.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of the Human Vocal Fold Lamina Propria Development Using Optical Coherence Tomography

et al. 2021

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“…The present study found that the transitional area of the lSCJ had poorly differentiated epithelial cells with characteristics of both stratified squamous cells and pseudostratified ciliated columnar epithelial cells. A previous study by Tucker et al used a scanning and transmission electron microscopy to demonstrate that the transitional area of the lSCJ has a gradual transition, rather than a sharp demarcation of cellular structure without cilia. The “stratified columnar epithelial cells” of the transitional area can ultimately evolve into a genuine stratified squamous cellular structure.…”

Section: Discussionmentioning

confidence: 99%

Pathological mechanisms of laryngeal papillomatosis based on laryngeal epithelial characteristics

Kurita

Chitose

Sato

et al. 2019

Laryngoscope Investig Oto

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Objectives Human papillomavirus (HPV) infects basal cells of the stratified squamous epithelium through micro epithelial trauma. However, laryngeal papillomatosis commonly appears in any site on the laryngeal mucosa not covered by stratified squamous epithelium. The purpose of this study is to clarify pathological mechanisms of laryngeal papillomatosis based on the characteristics of the laryngeal epithelium. Study Design Morphological and immunohistochemical study. Methods Larynges from one newborn and two adults were used. Morphological differences in the laryngeal squamo‐ciliary junction (lSCJ) were compared to those in the cervical squamo‐columnar junction (cSCJ) in a resected cervix uterus. Morphological characteristics of laryngeal epithelial distribution were also compared between the newborn and adult larynges. Immunohistochemical evaluations were performed using p63 (an epithelial stem‐cell marker) and integrin‐α6 (a cellular HPV receptor). Results Morphological differences were noted between the lSCJ and the cSCJ. The lSCJ was present in the adult, but not the newborn supraglottis. Goblet cells in the pseudostratified ciliated columnar epithelium were also found in the adult but not the newborn larynx. In addition, basal cells of the stratified squamous epithelium as well as the pseudostratified ciliated columnar epithelium expressed p63 and integrin‐α6 in both newborn and adult larynges. Conclusions HPV can infect any immature laryngeal epithelium with or without the lSCJ. Squamous metaplasia of pseudostratified ciliated columnar epithelium with a latent HPV infection can also cause tumorigenesis. Level of Evidence N/A

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“…[8][9][10][11] The Tucker Collection has also been studied by G. Tucker Jr and J. Tucker, and multiple publication references are noted. 2 …”

Section: Methodsmentioning

confidence: 99%

Posterior Commissure of the Human Larynx Revisited

Tucker

2010

Journal of Voice

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Survey of the Development of Laryngeal Epithelium

Cited by 26 publications

References 19 publications

Evaluation of the Human Vocal Fold Lamina Propria Development Using Optical Coherence Tomography

Evaluation of the Human Vocal Fold Lamina Propria Development Using Optical Coherence Tomography

Pathological mechanisms of laryngeal papillomatosis based on laryngeal epithelial characteristics

Posterior Commissure of the Human Larynx Revisited

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