Survey of rotavirus‐associated severe complications in Aichi Prefecture

Hattori, Fumihiko; Kawamura, Yoshiki; Kawada, Junji; Kojima, Seiji; Natsume, Jun; Ito, Koichi; Saito, Shinji; Kitagawa, Yoshiro; Okumura, Akihisa; Yoshikawa, Tetsushi

doi:10.1111/ped.13506

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…The other extraintestinal complications of RV involve the kidney, liver, respiratory tract, lymph node, and pancreas. 23 , 24 In our study, 1 patient had ischemic hepatitis (possibly related to cardiac arrest). Four patients had hypovolemic shock-related acute kidney injury.…”

Section: Discussionmentioning

confidence: 59%

Clinical Features and Outcomes of Children Admitted to the PICU due to Rotavirus Infection

Gün¹,

Kendirli²,

Öztürk³

et al. 2021

Turk Arch Pediatrics

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Objectives: In this study, we aimed to evaluate the clinical and laboratory features of the patients with rotavirus (RV) antigen positivity on or following admission to the pediatric intensive care unit (PICU). Methods: Patients admitted to the PICU due to community-acquired rotavirus (CA-RV) or hospital-acquired rotavirus (HA-RV)-induced gastroenteritis between January 1, 2013, and December 31, 2019 were evaluated. Results: Thirty-four patients with a mean age of 14.00 ± 19.17 months were enrolled. Forty-four percent were girls. Twenty (58.8%) patients had a history of chronic diseases. Nine (26.5%) patients had CA-RV and 25 (73.5%) patients had HA-RV infection. RV antigens were simultaneously found in 44.1% ( n = 14) of the other patients at the time of diagnosis. In the study sample, 5 patients had hyponatremia, 8 had hypernatremia, 6 had hypokalemia, 4 had hypoalbuminemia, 21 had leukocytosis, 2 had leukopenia and 3 had thrombocytopenia, and 17 had elevated C-reactive protein (CRP) levels. Three patients had seizures, 1 patient had cardiac arrest, and 2 patients had secondary bacteremia. The mean (SD) PICU length of stay was 6 (6.02) with CA-RV gastroenteritis. All CA-RV patients survived, but 8 of the HA-RV patients succumbed to causes other than RV. Conclusion: RV-related PICU admission is not rare, and occasional severe clinical consequences occur, especially in young children, with both CA-RV and HA-RV gastroenteritis. Appropriate timely intervention and meticulous follow-up improve survival.

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Section: Discussionmentioning

confidence: 59%

Clinical Features and Outcomes of Children Admitted to the PICU due to Rotavirus Infection

Gün¹,

Kendirli²,

Öztürk³

et al. 2021

Turk Arch Pediatrics

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“…Rotavirus (RV), a leading cause of gastroenteritis (GE) in children, causes substantial morbidity and mortality worldwide. In addition to the disease burdens related to hospitalization and outpatient visits caused by RVGE-induced dehydration, severe complications such as encephalitis [ 19 ] and sudden unexpected death [ 20 ] are also of concern in developed countries including Japan. To decrease this disease burden, two live-attenuated RV vaccines were introduced.…”

Section: Effectiveness Of the Rotavirus Vaccinementioning

confidence: 99%

Implementing vaccination policies based upon scientific evidence in Japan

Yoshikawa

2021

Vaccine

Self Cite

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The theme of the 24th Annual Meeting of the Japanese Society for Vaccinology was “Sustainable Future Medical Care Created by Vaccines.” This theme includes topics such as the proposal to reduce the medical costs incurred by societies with aging populations through prophylactic vaccination. The coronavirus disease 2019 (COVID-19) pandemic alerted us to the important roles that preventive measures, such as vaccines, play in fighting infectious diseases. In order to inform the public of the benefits of vaccines, it is important to provide society with information regarding new vaccine developments, adjuvants, the cost–benefit ratio of vaccine introduction, and vaccine effectiveness and safety. Clinical research is essential for obtaining evidence of vaccine effectiveness and safety. The United States Centers for Disease Control and Prevention (CDC) conducts active surveillance in defined areas before and after the introduction of vaccines and documents the reduction in infection rates as a measure of vaccine effectiveness. However, vaccine efficacy and side effects may vary by country and ethnicity. Therefore, it is necessary for individual countries to develop their own evidence-based surveillance programs. We have studied vaccine efficacy and documented side-effects observed in patients for the varicella and rotavirus vaccines in Japan. This review outlines the importance of providing scientific evidence for vaccine effectiveness and safety.

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“…4,5 There is no specific treatment for rotavirus other than fluid and electrolyte replacement to prevent several complication such as dehydration, sepsis, gastrointestinal (GI) bleeding, respiratory infections, myocarditis, hepatic abscess, hepatitis, seizures and meningoencephalitis. 6,7 Studies of rotavirus infection in children under-5 years previously have been conducted in some cities in Indonesia. In Jakarta, rotavirus infection was detected in 42%, twice more than norwalk like viruses (prototype of norovirus) infection in 1997-1999.…”

Section: Introductionmentioning

confidence: 99%

Identification of Acute Rotavirus Diarrhea and Analysis of its Risk Factors in Children Under-5 Years in Surabaya, Indonesia

2020

IJPHRD

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Background: Diarrhea is the most common disease among children and still a major cause of morbidity and mortality. Among the various causes of acute diarrhea in children, rotavirus is the most frequent one, especially in developing countries where universal rotavirus vaccination has not been introduced, including Indonesia.Objectives: This study aimed to determine the percentage of acute rotavirus diarrhea in children and analyze its risk factors in Tanah Kali Kedinding Primary Health Care,

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Survey of rotavirus‐associated severe complications in Aichi Prefecture

Abstract: According to the questionnaire survey in Aichi Prefecture, the incidence of the four severe RV-associated complications appears to have declined as the vaccination rate has increased.

Cited by 8 publications

References 20 publications

Clinical Features and Outcomes of Children Admitted to the PICU due to Rotavirus Infection

Clinical Features and Outcomes of Children Admitted to the PICU due to Rotavirus Infection

Implementing vaccination policies based upon scientific evidence in Japan

Identification of Acute Rotavirus Diarrhea and Analysis of its Risk Factors in Children Under-5 Years in Surabaya, Indonesia

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