Survey of Products Most Frequently Named in Ingestion Accidents in 1965

Verhulst, Henry L.; Crotty, John J.

doi:10.1002/j.1552-4604.1967.tb00024.x

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…29,82,87,90,113 Reports of benzodiazepine overdosage likewise commonly reach poison control centers. 68,106 The frequency of identification of benzodiazepines in toxicologic specimens is variable from center to center (Table VI), but in the most recent survey from an urban laboratory, 84 benzodiazepines were identified in 16% of 2,500 blood specimens from patients in whom drug overdosage was suspected. C onsequences of benzodiazepine overdosage.…”

Section: Discussionmentioning

confidence: 99%

Acute overdosage with benzodiazepine derivatives

Greenblatt

Allen

Noel

et al. 1977

Clin Pharma and Therapeutics

127

View full text Add to dashboard Cite

A total of 773 admissions to Massachusetts General Hospital between 1962 and 1975 were due to acute overdosage with one or more psychotropic drugs. Benzodiazepine overdosage, particularly with diazepam, increased relative to other psychotropic drugs over the years. Only 12 admissions were due to benzodiazepine overdosage alone, and none of these patients were seriously ill or had significant complications. Multiple drugs were ingested in the other 87 cases, and the frequency and severity of complications among these individuals depended upon the type and quantity of other nonbenzodiazepines taken. For example, 21 of 31 patients who ingested benzodiazepines together with barbiturates experienced severe central nervous system (CNS) depression, and 14 of 31 required assisted ventilation. However, the frequency of such complications was nearly identical in a group of patients who ingested barbiturates alone. This report and a review of the literature suggest that serious intoxication following overdosage with a benzodiazepine derivative alone is unusual. Ingestion of benzodiazepines together with other drugs appears to be considerably more common than benzodiazepine overdosage alone as a cause of intoxication. The severity of intoxication in such cases of multiple drug ingestion probably depends largely on the type and quantity of nonbenzodiazepines.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute overdosage with benzodiazepine derivatives

Greenblatt

Allen

Noel

et al. 1977

Clin Pharma and Therapeutics

127

View full text Add to dashboard Cite

show abstract

“…18 a Examples and conclusions presented here are drawn from an analysis of the 10 plants responsible for ingestions reported most frequently by poison control centers in 1965, as presented by the National Clearinghouse for Poison Control Centers. 25 Together they account for nearly half of all identified plant ingestions which in turn, as a class, are listed as sixth in incidence among the top 10 categories of ingestions reported as poisonings in the United States. In the following discussion these 10 plants are presented in descending order of incidence as reported.…”

mentioning

confidence: 99%