Survey of malaria and anti-dengue virus IgG among febrile HIV-infected patients attending a tertiary hospital in Abuja, Nigeria

Mustapha, Jelili Olaide; Emeribe, Anthony Uchenna; Abdullahi, Idris Nasir

doi:10.2147/hiv.s134023

Cited by 13 publications

(14 citation statements)

References 26 publications

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“…In this study, a relative higher prevalence of acute dengue was observed in children who did not adopt various protective measures against the mosquito bites, compared to those who practiced some protective measures such as frequency of wearing long sleeve shirts and trousers as well as frequency of indoor insecticide sprays. These observations may are in line with previous studies carried out in Pakistan [49–51] but contrast with those of Mustapha et al [52] who realized no association between dengue virus infection and protective measures.…”

Section: Discussionsupporting

confidence: 89%

A cross-sectional study of acute dengue infection in paediatric clinics in Cameroon

et al. 2019

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Background Dengue fever is the world’s fastest spreading mosquito borne viral infection. It is prevalent throughout both subtropical and tropical region, and affects over 128 countries. Dengue virus (DENV) infection poses a serious global public health challenge to three billion people, resulting in approximately 200 million cases of morbidity and 50,000 cases of mortality annually. In Cameroon like in most sub-Saharan African countries, DENV infection occur concurrently with other infectious diseases whose symptoms often overlap, rendering differential diagnosis challenging. This study aims at determining the frequency of acute dengue among febrile children under 15 years attending hospitals in some areas of Cameroon. Methods A total of 961 children under the age of 15 were recruited in a cross-sectional study using systematic sampling technique and by selecting each subject out of the three. The study was conducted in 10 public health centers in Cameroon. Demographic data and risk factors of the subjects were obtained using well-structured questionnaires. Dengue virus NS1 antigen, IgM and IgG were analysed using a Tell me fast® Combo Dengue NS1-IgG/IgM Rapid Test. An in-house ELISA test for dengue specific IgM antibody was equally performed for confirmation. Descriptive statistical analysis was performed using Graph pad version 6.0. Results A prevalence of 6.14% acute dengue virus infection was observed among children with febrile illness with a significant difference ( p = 0.0488) between males (4.7%) and females (7.7%). In addition, children who reportedly were unprotected from vectors, showed a comparatively higher prevalence of the disease seropositivity than those practicing protective measures. Conclusion DENV infection therefore is an important cause of fever among children in Cameroon. Thus, there is a need to include differential screening for DENV infections as a tool in the management of fever in children in the country. Electronic supplementary material The online version of this article (10.1186/s12889-019-7252-9) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 89%

A cross-sectional study of acute dengue infection in paediatric clinics in Cameroon

et al. 2019

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“…1 ). The studies were 21 eligible studies conducted from 2009 to 2020 [ 8 11 15 16 17 18 19 20 21 23 24 25 26 27 28 29 30 31 ]. Three out of the 21 studies reported co-circulation of all the 4 serotypes, while 2 studies separately reported co-circulation of DENV-1 & 2 and DENV-1 to 3 ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Dengue Virus is Hyperendemic in Nigeria from 2009 to 2020: A Contemporary Systematic Review

et al. 2021

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Backround Data on Dengue virus (DENV) infection prevalence, geographic distribution and risk factors are necessary to direct appropriate utilization of existing and emerging control strategies. This study aimed to determine the pooled prevalence, risk factors of DENV infection and the circulating serotypes within Nigeria from January 1, 2009 to December 31, 2020. Materials and methods Twenty-one studies out of 2,215 available articles were eligible and included for this systematic review. Relevant articles were searched, screened and included in this study according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) criteria. The risk of bias in primary studies was assessed by Cochrane's method. Heterogeneity of pooled prevalence was calculated using the chi-square test on Cochrane's Q statistic, which was quantified by I-square values. The random-effects analyses of proportions were used to determine the pooled prevalence of DENV antibodies, antigen and RNA from eligible studies. Results Of these, 3 studies reported co-circulation of all the 4 serotypes, while 2 separately reported co-circulation of DENV-1 &2 and DENV-1 to -3. All the antibody-based studies had significantly high heterogeneity (I 2 >90%, P <0.05), while the NS1 and PCR-based studies had low heterogeneity (I 2 <25%, P >0.05). The pooled prevalence of DENV IgM, IgG, RNA, NS1 and neutralizing antibodies were 16.8%, 34.7%, 7.7%, 7.7% and 0.7%, respectively. South-east Nigeria had the highest pooled DENV-IgG seropositivity, 77.1%. Marital status, gender, educational level and occupation status, the proximity of residence to refuse dumpsite, frequent use of trousers and long sleeve shirts were significantly associated with DENV IgG seropositivity ( P <0.05). Conclusion Based on these findings, it can be inferred that Nigeria is hyperendemic for Dengue fever and needs concerted efforts to control its spread within and outside the country.

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“…Just a handful of studies have reported these. 27 – 30 It is well known that Plasmodium falciparum , which happens to be the most virulent of the plasmodia, is the principal species in circulation in SSA, 3 but today molecular evidence shows that other Plasmodium spp. are increasingly causing malaria in the region.…”

Section: Prevalence Of Malaria and Hiv Coinfection (Mhc) In Ssamentioning

confidence: 99%

Malaria and HIV coinfection in sub-Saharan Africa: prevalence, impact, and treatment strategies

Kwenti¹

2018

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Malaria and HIV, two of the world’s most deadly diseases, are widespread, but their distribution overlaps greatly in sub-Saharan Africa. Consequently, malaria and HIV coinfection (MHC) is common in the region. In this paper, pertinent publications on the prevalence, impact, and treatment strategies of MHC obtained by searching major electronic databases (PubMed, PubMed Central, Google Scholar, ScienceDirect, and Scopus) were reviewed, and it was found that the prevalence of MHC in SSA was 0.7%–47.5% overall. Prevalence was 0.7%–47.5% in nonpregnant adults, 1.2%–27.8% in children, and 0.94%–37% in pregnant women. MHC was associated with an increased frequency of clinical parasitemia and severe malaria, increased parasite and viral load, and impaired immunity to malaria in nonpregnant adults, children, and pregnant women, increased in placental malaria and related outcomes in pregnant women, and impaired antimalarial drug efficacy in nonpregnant adults and pregnant women. Although a few cases of adverse events have been reported in coinfected patients receiving antimalarial and antiretroviral drugs concurrently, available data are very limited and have not prompted major revision in treatment guidelines for both diseases. Artemisinin-based combination therapy and cotrimoxazole are currently the recommended drugs for treatment and prevention of malaria in HIV-infected children and adults. However, concurrent administration of cotrimoxazole and sulfadoxine–pyrimethamine in HIV-infected pregnant women is not recommended, because of high risk of sulfonamide toxicity. Further research is needed to enhance our understanding of the impact of malaria on HIV, drug–drug interactions in patients receiving antimalarials and antiretroviral drugs concomitantly, and the development of newer, safer, and more cost-effective drugs and vaccines to prevent malaria in HIV-infected pregnant women.

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Survey of malaria and anti-dengue virus IgG among febrile HIV-infected patients attending a tertiary hospital in Abuja, Nigeria

Cited by 13 publications

References 26 publications

A cross-sectional study of acute dengue infection in paediatric clinics in Cameroon

A cross-sectional study of acute dengue infection in paediatric clinics in Cameroon

Dengue Virus is Hyperendemic in Nigeria from 2009 to 2020: A Contemporary Systematic Review

Malaria and HIV coinfection in sub-Saharan Africa: prevalence, impact, and treatment strategies

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