Survey of infants hospitalized for respiratory syncytial virus disease in Tokyo, 2018

Seimiya, Ayako; Morioka, Ichiro; Okahashi, Aya; Nagano, Nobuhiko; Yoda, Hitoshi

doi:10.1111/ped.14381

Cited by 2 publications

(3 citation statements)

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“…29 Thus, new and broader preventive strategies for RSV infections in young children are needed, including licensure of new vaccines and monoclonal antibodies in the future or administration of palivizumab, which is currently available, earlier in the year prior to the start of the RSV season. 29,30 This study has limitations. The definition of RSV infection in this study was based on ICD10 codes and thus not necessarily test-confirmed RSV positivity.…”

Section: Discussionmentioning

confidence: 95%

“…Furthermore, some patients are still hospitalized even after receiving prophylactic palivizumab during the peak of the RSV season 29 . Thus, new and broader preventive strategies for RSV infections in young children are needed, including licensure of new vaccines and monoclonal antibodies in the future or administration of palivizumab, which is currently available, earlier in the year prior to the start of the RSV season 29,30 …”

Section: Discussionmentioning

confidence: 99%

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Epidemiology of respiratory syncytial virus in Japan: A nationwide claims database analysis

Kobayashi

Togo

Agosti

2021

Pediatrics International

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Background Respiratory syncytial virus (RSV) is a major cause of hospitalization for bronchiolitis and pneumonia in infancy. In Japan, limited data are publicly available on RSV epidemiology and clinical characteristics among infants. Methods This retrospective study described RSV incidence, seasonality, patient characteristics, resource use, and clinical outcomes among Japanese children <2 years from January 2017 through December 2018. The RSV cases were identified using the Japanese Medical Data Center database. Results In the database, 9,711 and 8,509 RSV patients <2 years were identified in 2017 and 2018, respectively. Of these, 25% required hospitalization. Ninety percent of hospitalized patients did not have a known RSV risk factor. Nineteen percent of hospitalized patients experienced dehydration, and 12% had acute respiratory failure. Hospitalization lasted 1 week on average and 7% required some type of mechanical ventilation. The peak of hospitalizations occurred at 2 months. The incidence of RSV hospitalization in children <2 years was 23.2 per 1,000 person‐years, which increased to 35.4 per 1,000 for infants <6 months. This age group accounted for 40% of all RSV‐associated hospitalizations among children <2 years. Conclusions Roughly one‐fourth of all RSV patients <2 years were hospitalized. Ninety percent of these did not have an underlying risk condition. This underscores that RSV can cause serious disease among all young children. Three to four out of every 100 Japanese children <6 months were hospitalized for RSV, and this age group accounted for ~40% of all RSV‐associated hospitalizations. Novel and broad‐based RSV prevention strategies, especially those targeting young infants, are needed.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Epidemiology of respiratory syncytial virus in Japan: A nationwide claims database analysis

Kobayashi

Togo

Agosti

2021

Pediatrics International

View full text Add to dashboard Cite

show abstract

“…The percentage can be even higher in some countries. For example, it was reported in Japan that 98% of infants hospitalized for RSV were otherwise healthy ( 8 ). In addition, roughly 50% of all children hospitalized with RSV are born outside of the RSV season ( 9 ).…”

Section: Introduction: Rsv Burden Concerns All Infantsmentioning

confidence: 99%