Survey of Clinical and Pathological Characteristics and Outcomes of Patients With Prostate Cancer

Abstract

Introduction:The importance of implementation: Prostate cancer is the most common malignancy in men and the second leading cause of cancer death in developed countries. Therefore, further studies about the protests of disease, diagnosis and timely treatment are essential.Study Method:In this study, 80 prostate cancer patients admitted to Imam Khomeini Hospital, Urmia in Iran from 2000 to 2008 were reviewed. Patients were studied according to their age, clinical protests, Gleason scoring, positive family history, smoking, type of treatment and post-treatment conditions. Questionnaires were adjusted based on the objectives and the data were extracted from the medical records of patients and the desired results were achieved.Results:In this study, the most common age group for prostate cancer is older than 60 years (92/5%). The most common type of pathology for prostate cancer is adenocarcinoma that 93.75% of cases are included. Secondary TCC with secondary source is present in 5% and sarcoma in 1.25% of cases. 46.25% of patients with prostate cancer are smokers. The most common clinical symptoms among patients are obstructive symptoms (56.25%), and irritation of the urinary tract (52.81%). Hematuria in 26.25% and urinary incontinence in 5% of cases have been recorded. 16.3% of patients referred with metastatic symptoms. Most patients with prostate cancer have Gleason score 5-7 (40%). All patients were undergoing prostatectomy (82.5% TURP and 17.5% SPP) and 47.5% of cases were bilateral orchiectomy. The cases reviewed, 22 were followed that included 27.5% of cases. Among them, 6 people have died due prostate cancer (27.27%) that the mean age of the patients after diagnosis until death was 34.4 months. 2 others died from other causes (9.09%). The remaining 14 cases were elder patients with a mean follow-up duration of 44 months.Conclusion:According to the results obtained in the present study, the most common type of prostate cancer pathology is adenocarcinoma that is included 93.75% of cases. Prostate sarcoma is present at 1.25% and secondary bladder TCC at 5% of cases more over the incidence of prostate sarcoma is reported in a lower age group than adenocarcinoma, which the results obtained in a similar study in Iran in other centers. Regarding the relationship between smoking and prostate cancer it can be considered one of the important factors in this regard.

Clinical and Epidemiologic Characteristics of Castration Resistant Prostate Cancer Patients in Sulaimaniyah, Iraqi Kurdistan

“…As shown by the results of the present study, all cases and 94% of the controls were diagnosed with adenocarcinoma, while none of the cases and a small percentage of the controls (5.3%) were diagnosed with sarcoma, and the two groups were signi icantly different in this regard. This inding is in good agreement with the results of the studies in Iran (Tanago and Mcaninch, 2003;Alizadeh and Alizadeh, 2014). Therefore, it can be concluded that there is a signi icant association between adenocarcinoma and development of CRCP.…”

The Pathogenesis of Prostate Cancer

“…Using these cell types, it has been hypothesized that tumors arising from luminal cells will be more aggressive than those arising from basal cells (16). About 90-95% of prostate cancers are acinar adenocarcinomas that arise from the peripheral prostatic gland (17). Histological diagnosis is made by assessing the loss of surrounding basal cells, loss of normal glandular architecture, including the disruption to the epithelial-stromal basement membrane, and nuclear atypia of luminal cells (Figure 1) (18).…”

Associations between Statin/Omega3 Usage and MRI-Based Radiomics Signatures in Prostate Cancer

“…Two different ROIs were investigated, including the whole prostate gland and the peripheral region of the prostate. The whole prostate gland is the most common region reviewed by radiologists, while the peripheral zone is where over 90% of prostate cancers develop [ 30 ], so the two ROIs were separately analyzed to see if there was a performance difference. Through this study, we identified specific radiomics signatures that correlated with the use of these drugs and presented machine-learning models based on these signatures.…”

“…Using Velocity software (Varian Medical Systems, Palo Alto, CA, USA), each MRI scan was manually contoured on two separate ROIs: the prostate gland and the peripheral zone of the prostate. The whole prostate gland is the most common region reviewed by radiologists and also easy to contour for future studies, while the peripheral zone is where over 90% of prostate cancers develop [ 30 ]. Figure 1 shows the created contours on two example patients, with the prostate gland outlined in blue and its peripheral region outlined in red.…”