Survey of Cancer in Children Admitted to a Brazilian Charity Hospital&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

Marigo, Carlos; Müller, H; Davies, J. N. P.

doi:10.1093/jnci/43.6.1231

Cited by 8 publications

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“…Other southern and southeastern Brazilian states may also have a high prevalence of R337H and incidence of pediatric ACT in the population. For example, the first cluster of pediatric ACT was reported in a charity hospital in the city of Sao Paulo [ 13 ]. In another study involving 35,000 newborns in the city of Campinas, Sao Paulo, the prevalence of R337H was 0.21% [ 14 ], which is slightly inferior to that in Santa Catarina (0.24%) and Parana state (0.30%) [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Newborn Screening for the Detection of the TP53 R337H Variant and Surveillance for Early Diagnosis of Pediatric Adrenocortical Tumors: Lessons Learned and Way Forward

Tosin

Legal

Pianovski

et al. 2021

Cancers

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The incidence of pediatric adrenocortical tumors (ACT) is high in southern Brazil due to the founder TP53 R337H variant. Neonatal screening/surveillance (NSS) for this variant resulted in early ACT detection and improved outcomes. The medical records of children with ACT who did not participate in newborn screening (non-NSS) were reviewed (2012–2018). We compared known prognostic factors between the NSS and non-NSS cohorts and estimated surveillance and treatment costs. Of the 16 non-NSS children with ACT carrying the R337H variant, the disease stages I, II, III, and IV were observed in five, five, one, and five children, respectively. The tumor weight ranged from 22 to 608 g. The 11 NSS children with ACT all had disease stage I and were alive. The median tumor weight, age of diagnosis, and interval between symptoms and diagnosis were 21 g, 1.9 years, and two weeks, respectively, for the NSS cohort and 210 g, 5.2 years, and 15 weeks, respectively, for the non-NSS cohort. The estimated surveillance/screening cost per year of life saved is US$623/patient. NSS is critical for improving the outcome of pediatric ACT in this region. Hence, we strongly advocate for the inclusion of R337H in the state-mandated universal screening and surveillance.

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Section: Introductionmentioning

confidence: 99%

Newborn Screening for the Detection of the TP53 R337H Variant and Surveillance for Early Diagnosis of Pediatric Adrenocortical Tumors: Lessons Learned and Way Forward

Tosin

Legal

Pianovski

et al. 2021

Cancers

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Rapidly Progressive Proptosis Secondary to Burkitt's Lymphoma

Blakemore¹,

Ehrenberg²,

Fritz³

et al. 1983

Arch Ophthalmol

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Hodgkin's disease in Medellin, Colombia

Bedoya¹

1977

Z. Krebsforsch.

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Four hundred and fifty two cases of Hodgkin's disease (H.D.) were studied in Medellin, Colombia, following the Rye histological classification: The relative frequency of H.D. was 2.3% for all malignancies and 34% for the solid lymphoreticular tumors. The percentage of H.D. in children as compared with adults was 27%, which is higher than usually reported. The age curve of incidence was bimodal with a first high peak at age 5--9 years and a lower second peak between 15--25 years. Males predominated mainly in children, 4.5--1. The epidemiological pattern for H.D. in our area generally corresponded with the Type I recently described for developing countries; but a high frequency for Nodular Sclerosis in children, with unusual anatomical localizations, more severe clinical manifestations, and poorer prognosis seems to indicate complex factors in the etiopathogenesis of the disease in the same geographical area.

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Survey of Cancer in Children Admitted to a Brazilian Charity Hospital<xref ref-type="fn" rid="FN2">2</xref>

Cited by 8 publications

References 0 publications

Newborn Screening for the Detection of the TP53 R337H Variant and Surveillance for Early Diagnosis of Pediatric Adrenocortical Tumors: Lessons Learned and Way Forward

Newborn Screening for the Detection of the TP53 R337H Variant and Surveillance for Early Diagnosis of Pediatric Adrenocortical Tumors: Lessons Learned and Way Forward

Rapidly Progressive Proptosis Secondary to Burkitt's Lymphoma

Hodgkin's disease in Medellin, Colombia

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