Surveillance of Multidrug-Resistant Bacterial Infections in Non-Adult Patients — Zhejiang Province, China, 2014–2019

Abstract

Introduction Antimicrobial resistance has become a major public health threat globally. The prevalence of multidrug-resistant (MDR) bacterial infections increased substantially among inpatients under 18 years of age in recent years. In Zhejiang Province, China, the trends of drug-resistance in non-adult patients from 2014 to 2019 were monitored, aiming to determine the variation patterns and epidemiological features of MDR strains. Methods Patient data were collected from the Annual Review of Hospital Infection Resistance Survey in Zhejiang Province, 2014–2019. Statistical analysis was performed to analyze the pattern of distribution of five key bacterial pathogens in different age groups, ward settings, and bloodstream infections. Results From 2014 to 2019, a total of 30,163 multidrug-resistant strains were identified among 212,252 clinical isolates. The prevalence of extended spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E), carbapenem-resistant Enterobacteriaceae (CRE), carbapenem-resistant Acinetobacter baumannii , carbapenem-resistant Pseudomonas aeruginosa (CRPA), and methicillin-resistant Staphylococcus aureus (MRSA) were 40.6%, 2.3%, 14.7%, 9.0%, and 27.4%, respectively. The prevalence of these key pathogens was lower than that reported in the national surveillance system (China Antimicrobial Resistance Surveillance System and Infectious Diseases Surveillance of Pediatrics). The prevalence of ESBL-E and CRE decreased since 2015 but that of CRPA and MRSA increased from 2014 to 2018. Conclusions Despite an overall decrease in the prevalence of drug-resistant bacteria in 2019, the rising prevalence of MRSA and CRPA still warrant much attention. Multidrug-resistant bacteria prevention and control strategies should be adjusted in a timely manner based on the surveillance results.

Clinical Characteristics, Prognosis and Treatment of Bloodstream Infections with Enterobacter Cloacae Complex in a Chinese Tertiary Hospital: A Retrospective Study

“… 1 , 11 , 12 Notably, ESBL-producing Enterobacterales were classified as one of the most significant pathogens in the World Health Organization’s list of priority pathogens. 13 , 14 A nationwide survey conducted in China revealed that the prevalence of ESBL-producing Enterobacterales was as high as 40.6%. 14 …”

“… 13 , 14 A nationwide survey conducted in China revealed that the prevalence of ESBL-producing Enterobacterales was as high as 40.6%. 14 …”

“…1,11,12 Notably, ESBL-producing Enterobacterales were classified as one of the most significant pathogens in the World Health Organization's list of priority pathogens. 13,14 A nationwide survey conducted in China revealed that the prevalence of ESBL-producing Enterobacterales was as high as 40.6%. 14 Surveillance data collected on a global scale indicated that the prevalence of extended-spectrum β-lactamaseproducing E. cloacae complex (ESBL producing-ECC) infection has reached alarming levels, with rates as high as 28.6% in Asia 15 and 47.6% in Africa 16 over the past decade.…”

“…13,14 A nationwide survey conducted in China revealed that the prevalence of ESBL-producing Enterobacterales was as high as 40.6%. 14 Surveillance data collected on a global scale indicated that the prevalence of extended-spectrum β-lactamaseproducing E. cloacae complex (ESBL producing-ECC) infection has reached alarming levels, with rates as high as 28.6% in Asia 15 and 47.6% in Africa 16 over the past decade. The resistance of ECC to β-lactam antibiotics poses a significant challenge to clinical anti-infective treatment.…”

Microbiological characteristics and risk factors on prognosis associated with Acinetobacter baumannii bacteremia in general hospital: A single-center retrospective study

“…The timely and effective application of antibiotics is crucial for managing the morbidity and mortality of the infection ( Ferrer et al, 2014 ; Falcone et al, 2020 ). According to the report of the Chinese National Bacterial Drug Resistance Monitoring Network, Pseudomonas aeruginosa isolated from blood samples during 2014–2019 had the highest composition proportion, the second was A.baumannii ( Wu et al, 2021 ). In our previous studies, K.pneumonia was the most commonly isolated Gram-negative bacteria in affected intensive care unit (ICU) patients, the second was E. coli , and A.baumannii was in the third place ( Wu et al, 2022 ).…”