Surveillance of invasive meningococcal disease in the Tel Aviv District, Israel, 2007–2017

Salama, Matanelle; Kopel, Eran; Jaffe, Joseph; Amitai, Ziva; Rahmani, Sarit; Yuabov, Irina; Dardik, Laura; Valinsky, Lea

doi:10.1016/j.vaccine.2019.08.055

Cited by 2 publications

(8 citation statements)

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“…Previous epidemiological studies in Israel have estimated the overall IMD annual incidence, as approximately one per 100,000 population, during the last two decades differing between age groups [ 6 , 7 , 8 ]. The IMD incidence rates were higher among children and specifically in infants and toddlers (accounting for some two-thirds of the cases), with young children residing in low socio-economic areas showing higher incidence rates [ 6 , 7 , 8 ]. According to the bacterial isolates of N. meningitidis , the leading serogroup in Israel has been serogroup B (MENB) [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…The IMD incidence rates were higher among children and specifically in infants and toddlers (accounting for some two-thirds of the cases), with young children residing in low socio-economic areas showing higher incidence rates [ 6 , 7 , 8 ]. According to the bacterial isolates of N. meningitidis , the leading serogroup in Israel has been serogroup B (MENB) [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Invasive meningococcal infections attributable to the N. meningitidis serogroups A, B, C, W-135, and Y are potentially preventable by commercially available vaccines [ 7 , 8 , 9 ]. In Israel, three conjugate meningococcal vaccines (A-C-W-135-Y) and two vaccines against serogroup B (MenB-4C vaccine, Bexsero™, and MenB-fHbp vaccine, TruMenBa™) are registered [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Invasive Disease Due to Neisseria meningitidis: Surveillance and Trends in Israel Prior to and during the COVID-19 Pandemic

Stein-Zamir,

Shoob,

Abramson

et al. 2023

Microorganisms

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Invasive meningococcal disease (IMD) is a devastating disease with significant mortality and long-term morbidity. The COVID-19 pandemic and containment measures have affected the epidemiology of infectious pathogens. This study’s aim was to assess IMD trends in Israel prior to and during the COVID-19 pandemic. The Neisseria meningitidis invasive infection is a notifiable disease in Israel. Laboratory analysis includes serogrouping and molecular characterization. The overall national IMD incidence rate (1998–2022) was 0.8/100,000 population. The IMD incidence rates declined during the pandemic years (0.3/100,000 in 2020–2022 vs. 0.9/100,000 in 1998–2019). The number of notified IMD cases declined by 65% in 2020–2022. The case fatality rate among laboratory-confirmed IMD cases was 9% (47/521, 2007–2022). Mortality risk markers included cases’ age (older) and socio-economic status (lower). Overall, most Neisseria meningitidis isolates were of serogroup B (62.6%), and the most prevalent clonal complex (CC) was CC32 (24.2%). Serogroup B prevailed in cases aged 0–9 years (74.5%) and less in cases aged 10 years and above (39%). Neisseria meningitidis serogroups and CC distribution altered recently with a decline in serogroup B fraction, an increase in serogroup Y, and a decline in CC32. Ongoing IMD surveillance is necessary to assess trends in circulating strains and support decision-making on meningococcal vaccination programs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Invasive Disease Due to Neisseria meningitidis: Surveillance and Trends in Israel Prior to and during the COVID-19 Pandemic

Stein-Zamir,

Shoob,

Abramson

et al. 2023

Microorganisms

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“… 8 Serogroup B causes more than a third part of IMD, 4 9 but in some countries or population groups the proportion is even higher. 10 11 In Spain, from 2009 to 2018, serogroup B accounted for 64% of IMD cases. 12 A high proportion, up to 60% 13 of IMD cases, are affected by a range of sequelae and health-related impairment in the quality of life of survivors and their families.…”

Section: Introductionmentioning

confidence: 99%

“…Case fatality rate is about 10% in developed countries,4–6 and 40%–65% present with meningitis, but meningococcemia and pneumonia are also frequent,4 being the serogroup involved related both with the case fatality rate7 and the predominant clinical form 8. Serogroup B causes more than a third part of IMD,4 9 but in some countries or population groups the proportion is even higher 10 11. In Spain, from 2009 to 2018, serogroup B accounted for 64% of IMD cases 12.…”

Section: Introductionmentioning

confidence: 99%

Estimation of the incidence of invasive meningococcal disease using a capture–recapture model based on two independent surveillance systems in Catalonia, Spain

et al. 2022

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ObjectivesInvasive meningococcal disease (IMD) is an urgent notifiable disease and its early notification is essential to prevent cases. The objective of the study was to assess the sensitivity of two independent surveillance systems and to estimate the incidence of IMD.DesignWe used capture–recapture model based on two independent surveillance systems, the statutory disease reporting (SDR) system and the microbiological reporting system (MRS) of the Public Health Agency of Catalonia, between 2011 and 2015. The capture–recapture analysis and 95% CIs were calculated using the Chapman formula. Multivariate vector generalised linear model was performed for adjusted estimation.MeasuresThe variables collected were age, sex, year of report, size of municipality (<10 000 and ≥10 000), clinical form, death, serogroup, country of birth and type of reporting centre (private and public).ResultsThe sensitivity of the two combined surveillance systems was 88.5% (85.0–92.0). SDR had greater sensitivity than the MRS (67.9%; 62.7–73.1 vs 64.7%; 59.4–70.0). In 2014–2015, the sensitivity of both systems was higher (80.6%; 73.2–87.9 vs 73.4%; 65.2–81.6) than in 2011–2013 (59.3%; 52.6–66.0 vs 58.3%; 51.6–65.1). In private centres, the sensitivity was higher for SDR than for MRS (100%; 100–100 vs 4.8%; −4.4–13.9). The adjusted estimate of IMD cases was lower than that obtained using the Chapman formula (279; 266–296 vs 313; 295–330). The estimated adjusted incidence of IMD was 0.7/100 000 persons-year.ConclusionsThe sensitivity of enhanced surveillance through the combination of two complementary sources was higher than for the sources individually. Factors associated with under-reporting in different systems should be analysed to improve IMD surveillance.

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Surveillance of invasive meningococcal disease in the Tel Aviv District, Israel, 2007–2017

Cited by 2 publications

References 14 publications

Invasive Disease Due to Neisseria meningitidis: Surveillance and Trends in Israel Prior to and during the COVID-19 Pandemic

Invasive Disease Due to Neisseria meningitidis: Surveillance and Trends in Israel Prior to and during the COVID-19 Pandemic

Estimation of the incidence of invasive meningococcal disease using a capture–recapture model based on two independent surveillance systems in Catalonia, Spain

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