Surveillance of Influenza and Other Airborne Transmission Viruses during the 2021/2022 Season in Hospitalized Subjects in Tuscany, Italy

Milano, Giovanna; Capitani, Elena; Camarri, Andrea; Bova, G; Capecchi, Pier Leopoldo; Lazzeri, Giacomo; Lipari, Dario; Montomoli, Emanuele; Manini, Ilaria

doi:10.3390/vaccines11040776

Cited by 4 publications

(8 citation statements)

References 29 publications

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“…Fourteen [32,38,40,41,44,46,48,51,53,58,61–66] out of 29 full-length articles were judged at low risk of bias, while the remaining 15 studies [30,33–37,42,49,50,52,54–56,59,60,64–66] had at least one possible source of bias (S5 Table). The most frequent criticalities concerned insufficient description of patients and setting, inappropriate sample frame and small sample size.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies reported data on viral co-detections [30,31,36,37,40,47,51,53,54,[60][61][62][63]. However, only five estimates [37,47,51,53,63] were based on a sufficient (≥30) number of RSV-positive samples and were therefore less prone to the small study effect (S11 Table ).…”

Section: Prevalence Of Viral Co-detectionsmentioning

confidence: 99%

“…f All patients had cystic fibrosis; g Number imputed from the available percentages; ARI, Acute respiratory infection; CAP, community-acquired pneumonia; COPD, Chronic obstructive pulmonary disease; ED, Emergency department; HDR, Hospital discharge record; ICD, International Statistical Classification of Diseases and Related Health Problems; ICU, Intensive care unit; IFA, Immunofluorescence assay; ILI, Influenza-like illness; L, Lower respiratory tract specimens; LRTD, Lower respiratory tract disease; NA, Not available; RT-PCR, Reverse-transcription polymerase chain reaction; SARI, Severe Acute respiratory infection; U, Upper respiratory tract specimens; U/L, Upper and lower respiratory tract specimens; URTI, Upper respiratory tract infection.Fourteen[32,38,40,41,44,46,48,51,53,58,[61][62][63][64][65][66] out of 29 full-length articles were judged at low risk of bias, while the remaining 15 studies[30,[33][34][35][36][37]42,49,50,52,[54][55][56]59,60,[64][65][66] had at least one possible source of bias (S5 Table…”

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confidence: 99%

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Epidemiology and burden of respiratory syncytial virus in Italian adults: A systematic review and meta-analysis

Domnich,

Calabrò

2024

Preprint

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Objective Respiratory syncytial virus (RSV) is a common respiratory pathogen not only in children, but also in adults. Country-specific data on the epidemiology and burden of disease are essential for policy decisions. In view of a recent authorization of adult RSV vaccines, we aimed to comprehensively collect and assess evidence on the epidemiology and burden of RSV in Italian adults. Methods A systematic literature review was conducted according to the available guidelines. Random-effects proportional meta-analysis was performed to obtain pooled estimates and the observed heterogeneity was investigated by using both subgroup and meta-regression analyses. Results A total of 35 studies were identified. RSV seasonal attack rates ranged from 0.8 ‰ in community-dwelling older adults to 10.9% in hematological outpatients. On average, 4.5% (95% CI: 3.2-5.9%) of respiratory samples tested positive for RSV. This positivity prevalence was higher in older adults (4.4%; 95% CI: 2.8-6.3%) than in working-age adults (3.5%; 95% CI: 2.5-4.6%) and in outpatient (4.9%; 95% CI: 3.1-7.0%) than inpatient (2.9%; 95% CI: 1.5-4.8%) settings. Study location and sample size were also significant predictors of RSV detection frequency. The pooled estimate of in-hospital mortality was as high as 7.2% (95% CI: 4.7-10.3%). However, other important indicators of the diseases burden, such as complication and hospitalization rates, are missing. Conclusion RSV poses a measurable burden on Italian adults, especially those of older age and with some co-morbidities. Policy makers should give priority to health technology assessment of the novel RSV vaccines.

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Section: Resultsmentioning

confidence: 99%

Section: Prevalence Of Viral Co-detectionsmentioning

confidence: 99%

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confidence: 99%

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Epidemiology and burden of respiratory syncytial virus in Italian adults: A systematic review and meta-analysis

Domnich,

Calabrò

2024

Preprint

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“…Thirteen studies reported data on viral co-detections [30,31,36,37,40,47,51,53,54,[60][61][62][63]. However, only five estimates [37,47,51,53,63] were based on a sufficient (�30) number of RSV-positive samples and were therefore less prone to the small study effect (S11 Table ).…”

Section: Prevalence Of Viral Co-detectionsmentioning

confidence: 99%

“…Out-of-season samples were frequent (38%; 13/34) and most studies analyzed only (56%; 19/34) upper respiratory tract specimens. The majority (74%; 26/35) of studies were funded by public institutions.Fourteen[32,38,40,41,44,46, 48,51,53,58,[61][62][63][64][65][66] out of 29 full-length articles were judged at low risk of bias, while the remaining 15 studies [30,33-37, 42, 49, 50, 52, 54-56, 59, 60, 64-66] had at least one possible source of bias (S5 Table). The most frequent criticalities concerned insufficient description of patients and setting, inappropriate sample frame and small sample size.…”

mentioning

confidence: 99%

Epidemiology and burden of respiratory syncytial virus in Italian adults: A systematic review and meta-analysis

Domnich,

Calabrò

2024

PLoS ONE

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Objective Respiratory syncytial virus (RSV) is a common respiratory pathogen not only in children, but also in adults. In view of a recent authorization of adult RSV vaccines in Italy, our research question was to quantify the epidemiology and burden of RSV in Italian adults. Methods Observational studies on the epidemiology and clinical burden of laboratory-confirmed or record-coded RSV infection in Italian adults of any age were eligible. Studies with no separate data for Italian adults, modeling and other secondary publications were excluded. A literature search was performed in MEDLINE, Biological Abstracts, Global Health, Scopus and Web of Science on 22 November 2023. Critical appraisal was performed by means of a Joanna Briggs Institute checklist. Random-effects (RE) meta-analysis was performed to obtain pooled estimates and the observed heterogeneity was investigated by subgroup and meta-regression analyses. The protocol was prospectively registered (doi.org/10.17504/protocols.io.5qpvo32odv4o/v1). Results Thirty-five studies were identified, most of which had at least one possible quality concern. RSV seasonal attack rates ranged from 0.8 ‰ in community-dwelling older adults to 10.9% in hematological outpatients. In the RE model, 4.5% (95% CI: 3.2–5.9%) of respiratory samples tested positive for RSV. This positivity prevalence was higher in older adults (4.4%) than in working-age adults (3.5%) and in outpatient (4.9%) than inpatient (2.9%) settings. According to the meta-regression, study location and sample size were also significant predictors of RSV detection frequency. The pooled estimate of in-hospital mortality was as high as 7.2% (95% CI: 4.7–10.3%). Data on other indicators of the diseases burden, such as complication and hospitalization rates, were unavailable. Conclusion RSV poses a measurable burden on Italian adults, especially those of older age and with some co-morbidities. However, several data on the natural history of RSV disease are missing and should be established by future large-scale studies.

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Epidemiology and burden of Severe Acute Respiratory Infections (SARI) in the aftermath of COVID-19 pandemic: A prospective sentinel surveillance study in a Tunisian Medical ICU, 2022/2023

Boussarsar,

Ennouri,

Habbachi

et al. 2023

PLoS ONE

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Background Severe Acute Respiratory Infections (SARI) caused by influenza and other respiratory viruses pose significant global health challenges, and the COVID-19 pandemic has further strained healthcare systems. As the focus shifts from the pandemic to other respiratory infections, assessing the epidemiology and burden of SARI is crucial for healthcare planning and resource allocation. Aim: to understand the impact of the post-pandemic period on the epidemiology of SARI cases, clinical outcomes, and healthcare resource utilization in Tunisia. Methods This is a prospective study conducted in a Tunisian MICU part of a national sentinel surveillance system, focusing on enhanced SARI surveillance. SARI cases from week 39/2022, 26 September to week 19/2023, 13 May were included, according to a standardized case definition. Samples were collected for virological RT-PCR testing, and an electronic system ensured standardized and accurate data collection. Descriptive statistics were performed to assess epidemiology, trends, and outcomes of SARI cases, and univariate/multivariate analyses to assess factors associated with mortality. Results Among 312 MICU patients, 164 SARI cases were identified during the study period. 64(39%) RT-PCR were returned positive for at least one pathogen, with influenza A and B strains accounting for 20.7% of cases at the early stages of the influenza season. The MICU experienced a significant peak in admissions during weeks 1-11/2023, leading to resource mobilization and the creation of a surge unit. SARI cases utilized 1664/3120 of the MICU-stay days and required 1157 mechanical ventilation days. The overall mortality rate among SARI cases was 22.6%. Age, non-COPD, and ARDS were identified as independent predictors of mortality. Conclusions The present study identified a relatively high rate of SARI cases, with 39% positivity for at least one respiratory virus, with influenza A and B strains occurring predominantly during the early stages of the influenza season. The findings shed light on the considerable resource utilization and mortality associated with these infections, underscoring the urgency for proactive management and efficient resource allocation strategies.

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Surveillance of Influenza and Other Airborne Transmission Viruses during the 2021/2022 Season in Hospitalized Subjects in Tuscany, Italy

Cited by 4 publications

References 29 publications

Epidemiology and burden of respiratory syncytial virus in Italian adults: A systematic review and meta-analysis

Epidemiology and burden of respiratory syncytial virus in Italian adults: A systematic review and meta-analysis

Epidemiology and burden of respiratory syncytial virus in Italian adults: A systematic review and meta-analysis

Epidemiology and burden of Severe Acute Respiratory Infections (SARI) in the aftermath of COVID-19 pandemic: A prospective sentinel surveillance study in a Tunisian Medical ICU, 2022/2023

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