Surveillance of Group B Streptococcal Toxic Shock-Like Syndrome in Nonpregnant Adults and Characterization of the Strains in Japan

Chang, Bin; Ikebe, Tadayoshi; Wada, Akihito; Ogata, Kikuyo; Tomita, Masaaki; Katsukawa, Chihiro; Kawahara, Ryuji; Suzuki, Rieko; Endo, Miyoko; Isobe, Junko; Tanaka, Daisuke; Hirasawa, Kyoko; Watanabe, Haruo; ,

doi:10.7883/yoken.jjid.2006.182

Jpn J Infect Dis

2006

DOI: 10.7883/yoken.jjid.2006.182

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Surveillance of Group B Streptococcal Toxic Shock-Like Syndrome in Nonpregnant Adults and Characterization of the Strains in Japan

Bin Chang,

Tadayoshi Ikebe,

Akihito Wada

et al.

Abstract: Nine group B streptococci (GBS) strains were isolated from five toxic shock-like syndrome cases of nonpregnant adults in Japan from 2001 to 2005. All of them were identified as Streptococcus agalactiae. The serotypes of these strains were Ib, III, V, and VII. Pulsed-field gel electrophoresis revealed that the patterns of the strains isolated from the different patients were variable. Antimicrobial susceptibility tests showed that all of the strains were susceptible to penicillin G, ampicillin, cefotaxime, clin… Show more

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Cited by 3 publications

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Invasive Group B Streptococcal Disease in Non-pregnant Adults

2008

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Streptococcus agalactiae, commonly referred as group B Streptococcus (GBS), is a major cause of neonatal sepsis and infections in pregnant women. However, the number of invasive infections in non-pregnant adults is growing. Elderly patients and those with chronic underlying conditions, such as diabetes mellitus or compromised immune defence, are at increased risk of invasion. The spectrum of clinical manifestations is broad and includes necrotizing fasciitis and toxic shock syndrome. Although, primary bacteremia and skin and soft-tissue infections are the most frequently reported diagnosis. This article reviews the epidemiology, pathogenesis and treatment of invasive GBS disease in non-pregnant adults, with an emphasis on skin and soft-tissue infections.

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Invasive Group B Streptococcal Disease in Non-pregnant Adults

2008

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Dual RNA sequencing of group B Streptococcus-infected human monocytes reveals new insights into host–pathogen interactions and bacterial evasion of phagocytosis

Sullivan

Prince

Goh

et al. 2023

Sci Rep

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Streptococcus agalactiae, also known as Group B Streptococcus (GBS) is a frequent cause of infections, including bacteraemia and other acute diseases in adults and immunocompromised individuals. We developed a novel system to study GBS within human monocytes to define the co-transcriptome of intracellular GBS (iGBS) and host cells simultaneously using dual RNA-sequencing (RNA-seq) to better define how this pathogen responds to host cells. Using human U937 monocytes and genome-sequenced GBS reference strain 874,391 in antibiotic protection assays we validated a system for dual-RNA seq based on measures of GBS and monocyte viability to ensure that the bacterial and host cell co-transcriptome reflected mainly intracellular (iGBS) rather than extracellular GBS. Elucidation of the co-transcriptome revealed 1119 dysregulated transcripts in iGBS with most genes, including several that encode virulence factors (e.g., scpB, hvgA, ribD, pil2b) exhibiting activation by upregulated expression. Infection with iGBS resulted in significant remodelling of the monocyte transcriptome, with 7587 transcripts differentially expressed including 7040 up-regulated and 547 down-regulated. qPCR confirmed that the most strongly activated genes included sht, encoding Streptococcal Histidine Triad Protein. An isogenic GBS mutant strain deficient in sht revealed a significant effect of this gene on phagocytosis of GBS and survival of the bacteria during systemic infection in mice. Identification of a novel contribution of sht to GBS virulence shows the co-transcriptome responses elucidated in GBS-infected monocytes help to shape the host–pathogen interaction and establish a role for sht in the response of the bacteria to phagocytic uptake. This study provides comprehension of concurrent transcriptional responses that occur in GBS and human monocytes that shape the host–pathogen interaction.

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Recurrent <i>Streptococcus agalactiae</i> Toxic Shock Syndrome Triggered by a Tumor Necrosis Factor-α Inhibitor

et al. 2016

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Streptococcal toxic shock syndrome caused by group B streptococcus (GBS) is a rare, but lethal disease. We experienced a 45-year-old woman with pustular psoriasis who developed toxic shock-like syndrome during infliximab treatment. Surprisingly, similar episodes recurred three times in one year with restarting of infliximab treatments. In the third episode, GBS were detected in blood, urine, and vaginal secretion cultures. These episodes of shock syndrome were possibly due to GBS. To the best of our knowledge, this is the first case report of recurrent streptococcal toxic shock syndrome possibly caused by GBS which was induced by anti-TNF-α inhibitor therapy. The restarting of biological agents in patients with a history of toxic shock syndrome should therefore be avoided as much as possible.

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Surveillance of Group B Streptococcal Toxic Shock-Like Syndrome in Nonpregnant Adults and Characterization of the Strains in Japan

Cited by 3 publications

References 24 publications

Invasive Group B Streptococcal Disease in Non-pregnant Adults

Invasive Group B Streptococcal Disease in Non-pregnant Adults

Dual RNA sequencing of group B Streptococcus-infected human monocytes reveals new insights into host–pathogen interactions and bacterial evasion of phagocytosis

Recurrent <i>Streptococcus agalactiae</i> Toxic Shock Syndrome Triggered by a Tumor Necrosis Factor-α Inhibitor

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