Surveillance of donated blood during the 2016 arbovirus outbreak in Brazil

Sharma, Rohit; Santos, Larissa Costa; Silva, Robson A da; Gonçalves, Caroline Vieira; Calado, Stéfano de Melo; Santos, Denisar P; Melo, Josana de Andrade de P; Rampazzo, Rita de Cássia Pontello; Requião, Luciana; Krieger, Marco Aurélio; Barral‐Netto, Manoel; Oliveira, Camila I. de

doi:10.1002/jmv.25193

Cited by 7 publications

(7 citation statements)

References 21 publications

(21 reference statements)

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“…Similarly, the first report for ZIKV RNA prevalence among blood donors in the USA outside the states with active transmission of this virus revealed a prevalence of 0.001% [18]. Additionally, a recent study performed in blood donors in a north-east Brazilian city (Vit oria da Conquista) with a similar to our sample number, also did not find any RNA-positive sample [19]. On the other hand, our study largely contrasts to the data obtained in Ribeirão Preto city, south-east Brazil, where ZIKV RNA prevalence among blood donors was 2.7% [5].…”

Section: Discussionsupporting

confidence: 86%

Prevalence of Zika Virus (Zikv) in blood donors from a hemotherapy service of the southern region of Brazil

Diefenbach

Slavov

Kashima

et al. 2018

ISBT Science Series

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Background and objectives Zika virus is a flavivirus transmitted by Aedes mosquitos. A discussed transmission route is by blood transfusion due to the large number of ZIKV asymptomatic cases. The objective of the study was to estimate the ZIKV IgG seroprevalence and RNA presence in blood donors from a Hemotherapy Service in Southern Brazil due to the fact that until the end of 2016, 851 ZIKV suspected cases, 51.2% of which were with autochthons transmission were reported in this Brazilian region. Materials and methods Five hundred blood samples were collected from blood donors between 5 December 2016 and 6 January 2017 in the Hemotherapy Service of Santa Maria, Rio Grande do Sul, Brazil. All samples were tested for the presence of ZIKV RNA by the use of TaqMan® real‐time PCR and 182 of these were serologically assessed for ZIKV IgG. Results No samples showed positive results for ZIKV RNA. However, the serological survey detected one positive sample for ZIKV IgG and four samples with optical density values in the grey zone (consequently three of them confirmed as Dengue IgG‐positive). This indicates a 0.55% seroprevalence of ZIKV IgG among volunteer blood donors in the city of Santa Maria, Rio Grande do Sul State, Brazil. Conclusion Our results demonstrate that although the transfusion risk of ZIKV in the south part of the country can be currently considered as low, further outbreaks cannot be excluded due to lack of herd immunity to ZIKV. Our study adds to the national and global prevalence of ZIKV among blood donors and its implications for the transfusion safety.

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Section: Discussionsupporting

confidence: 86%

Prevalence of Zika Virus (Zikv) in blood donors from a hemotherapy service of the southern region of Brazil

Diefenbach

Slavov

Kashima

et al. 2018

ISBT Science Series

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“…The obtained results differ significantly from the ZIKV prevalence obtained for blood donors in the São Paulo State, Brazil 5 and French Polynesia, 4 where it was up to 3 %. On the contrary, our results were concordant with other studies performed in Brazil, especially in Northeast 8 and South Brazil. 9 where the detected ZIKV RNA prevalence was 0.0 %.…”

supporting

confidence: 92%

“…We adopted as a true estimated ZIKV prevalence the mean prevalence obtained from four previous studies examining ZIKV infection in Brazilian blood donors (0.71 %). 5 , 7 , 8 , 9 The minimum sample size calculated to be tested for estimation of the ZIKV prevalence in blood donors was 269 donations; however, we tested a higher number of samples (475 blood donations).…”

mentioning

confidence: 81%

“… 9 where the detected ZIKV RNA prevalence was 0.0 %. In both studies, the authors claimed that the negative result might have been a consequence of the lower number of suspected ZIKV cases in the general population reported in the study period, 8 , 9 compared to locations with large ZIKV outbreaks, such as São Paulo State. This situation can be similar to ours, in which only 777 probable ZIKV cases were reported by an epidemiological bulletin in the general population of the Federal District of Brazil.…”

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confidence: 98%

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Zika virus RNA surveillance in blood donors in the Federal District of Brazil during the 2016 outbreak

Slavov

Gonzaga

Pimentel³

et al. 2020

Hematology, Transfusion and Cell Therapy

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“…Contudo existem outras doenças que podem ser transmitidas via transfusão de sangue que não passam pelo processo de exames laboratoriais de alta sensibilidade nos bancos de sangue, como as arboviroses causadas pelos vírus Dengue, Zika, Chikungunya, dentre outros (CUNHA et al 2016;BARJAS-CASTRO et al 2016;GA-LEL et al 2017;SHARMA et al 2018).…”

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Estudo sobre infecções por Alphavirus e Flavivirus em amostras de banco de sangue

Romeiro¹

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Os primeiros bancos de sangue no Brasil foram fundados em 1941. Com a descoberta do vírus da Imunodeficiência Humana (HIV) e principalmente a partir de 1988, os doadores passaram a ser cadastrados e o sangue triado para alguns patógenos. Contudo, arbovírus como os do Dengue, já descrito em casos de transmissão via transfusional, não são triados em doadores, e com a emergência dos vírus Zika e Chikungunya este risco se tornou ainda maior. O presente trabalho, realizado em 2017 e 2018, estuda infecções por Alphavirus e Flavivirus em doadores de sangue na cidade de São Carlos, SP. Foram analisados plasmas de 5.608 doadores de sangue por pesquisa dos genomas destes vírus e de anticorpos, bem como testes de neutralização. Observou-se que 4 doadores estavam infectados com vírus Zika representando risco de transmissão viral a receptores de produtos dos seus sangues. Oito doadores apresentavam anticorpos IgM específicos para CHIKV, mostrando que, em período anterior recente, no qual ocorreram alguns casos na comunidade, doadores teriam oferecido risco de transmissão a receptores de produtos dos seus sangues. A ocorrência de 36 doadores IgM-positivos para vírus Mayaro e ainda outros 11 com anticorpos neutralizantes específicos, sugere que, em período anterior recente, estes indivíduos tenham se infectado por este vírus com risco de transmissão a receptores de produtos dos seus sangues. O inédito diagnóstico sorológico de infecções por Mayaro em doadores de sangue evidencia que este vírus deva ter circulado, ou estar circulando, inadvertido, no Estado de São Paulo, a causar infecção humana, o que exige a atenção do Sistema de Saúde Pública. Palavras Chaves: Banco de sangue, arbovírus, RT-PCR em tempo real, Alphavirus e Flavivirus. ROMEIRO, M.F. A study on alphavirus and flavivirus infections in blood bank samples. 2019-75f. Tese (

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Surveillance of donated blood during the 2016 arbovirus outbreak in Brazil

Cited by 7 publications

References 21 publications

Prevalence of Zika Virus (Zikv) in blood donors from a hemotherapy service of the southern region of Brazil

Prevalence of Zika Virus (Zikv) in blood donors from a hemotherapy service of the southern region of Brazil

Zika virus RNA surveillance in blood donors in the Federal District of Brazil during the 2016 outbreak

Estudo sobre infecções por Alphavirus e Flavivirus em amostras de banco de sangue

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