Surveillance of Antibiotic Susceptibility Patterns of &lt;i&gt;Neisseria gonorrhoeae&lt;/i&gt; from 2013 to 2015 in Guangxi Province, China

Li, Wei; Zhu, Bang-Yong; Qin, Shui-Qing; Yang, Mao-Chun; Ming, Liang; He, Shao; Chen, Huai-Zhong; Gan, Quan; Huang, Yin-Jie; Wei, Jiang-ping; He, Ji-Zhao; Chen, Zhen; Bu, Jin

doi:10.7883/yoken.jjid.2017.169

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Furthermore, a similar incidence was reported among 384 isolates from Nanjing during 2013–2014, with 32% of isolates displaying AZM-R and 10% showing high-level resistance 11. Notably, the levels of resistance to azithromycin observed in earlier studies from other regions in China were lower 25,26. As two neighboring countries in Asia, the resistance rates of N. gonorrhoeae isolated from China and Japan to azithromycin are much higher than those from Europe and America 2,27–29.…”

Section: Discussionsupporting

confidence: 77%

<p>Antimicrobial Resistance And Molecular Characteristics Among Neisseria gonorrhoeae Clinical Isolates In A Chinese Tertiary Hospital</p>

Zheng¹,

Liu²,

Shen³

et al. 2019

IDR

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PurposeThe resistance of N. gonorrhoeae to antimicrobial agents has been increasing year by year due to the overuse of antibiotics. The primary aims of the present study were to investigate the molecular characteristics of the clinical isolates of Neisseria gonorrhoeae and the resistance to azithromycin in a Chinese tertiary hospital.MethodsFrom January 2014 to May 2017, a total of 55 clinical isolates of N. gonorrhoeae were collected. Genes associated with azithromycin resistance (AZM-R), including mutations in 23S rRNA alleles, the mtrR promoter and coding regions, and rplD and rplV were evaluated by PCR and DNA sequencing. All clinical isolates were subjected to N. gonorrhoeae multiantigen sequence typing (NG-MAST), while the AZM-R isolates were further characterized by multilocus sequence typing (MLST).ResultsThe AZM-R rate in this study was 23.64% (13/55), and a single (A)-nucleotide deletion mutation in the mtrR promoter region, a G45D mutation in the mtrR coding region, a point mutation in rplD, and an A2047G mutation in 23S rRNA alleles were detected in 13, 4, 3 and 4 isolates, respectively; no mutations were found in rplV. There was no significant difference in the mtrR coding region mutation rate between the azithromycin-sensitive and AZM-R groups (P > 0.05); however, there was a significant difference in the mutation rate of the mtrR promoter region (P < 0.05). Among the 55 isolates studied, 43 distinct NG-MAST were determined, while the AZM-R isolates were allocated into 10 distinct MLST/NG-MAST combinations. All three isolates with high-level AZM-R belonged to the sequence types (STs) NG-MAST ST1866 and MLST ST10899.ConclusionN. gonorrhoeae clinical isolates from Wenzhou, eastern China, showed considerable genetic diversity. Measures should be implemented to monitor the spread of the NG-MAST ST1866 and MLST ST10899 N. gonorrhoeae clones, which exhibit high-level AZM-R in eastern China.

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Section: Discussionsupporting

confidence: 77%

<p>Antimicrobial Resistance And Molecular Characteristics Among Neisseria gonorrhoeae Clinical Isolates In A Chinese Tertiary Hospital</p>

Zheng¹,

Liu²,

Shen³

et al. 2019

IDR

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“…gonorrhoeae isolates between 2009 and 2016, and the calculated AZM resistance ranged between a high of 28.6% and 3.6% of isolates tested in China. 83 , 84 , 85 , 86 Moreover, two studies from India and Taiwan presented the overall percentage of AZM resistance in N . gonorrhoeae isolates—5% and 14.6%, respectively.…”

Section: Azithromycin Resistancementioning

confidence: 99%

“…These studies examined the susceptibility of N. gonorrhoeae isolates between 2009 and 2016, and the calculated AZM resistance ranged between a high of 28.6% and 3.6% of isolates tested in China. [83][84][85][86] Moreover, two studies from India and Taiwan presented the overall percentage of AZM resistance in N. gonorrhoeae isolates-5% and 14.6%, respectively. 75,79 The resistance mechanism mentioned in relation to these resistant isolates was mutations in 23S rRNA, penA, and mtrA genes.…”

Section: Asiamentioning

confidence: 99%

Mechanism of action, resistance, synergism, and clinical implications of azithromycin

Heidary

Samangani

Kargari

et al. 2022

Clinical Laboratory Analysis

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Background Azithromycin (AZM), sold under the name Zithromax, is classified as a macrolide. It has many benefits due to its immunomodulatory, anti‐inflammatory, and antibacterial effects. This review aims to study different clinical and biochemisterial aspects and properties of this drug which has a priority based on literature published worldwide. Methods Several databases including Web of Science, Google Scholar, PubMed, and Scopus were searched to obtain the relevant studies. Results AZM mechanism of action including the inhibition of bacterial protein synthesis, inhibition of proinflammatory cytokine production, inhibition of neutrophil infestation, and macrophage polarization alteration, gives it the ability to act against a wide range of microorganisms. Resistant organisms are spreading and being developed because of the irrational use of the drug in the case of dose and duration. AZM shows synergistic effects with other drugs against a variety of organisms. This macrolide is considered a valuable antimicrobial agent because of its use as a treatment for a vast range of diseases such as asthma, bronchiolitis, COPD, cystic fibrosis, enteric infections, STIs, and periodontal infections. Conclusions Our study shows an increasing global prevalence of AZM resistance. Thus, synergistic combinations are recommended to treat different pathogens. Moreover, continuous monitoring of AZM resistance by registry centers and the development of more rapid diagnostic assays are urgently needed.

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Antimicrobial resistance of Neisseria gonorrhoeae in Jakarta, Indonesia: a cross-sectional study

et al. 2020

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Background Neisseria gonorrhoeae has developed resistance to various antimicrobials. At least 10 countries have reported treatment failures with extended-spectrum cephalosporins. Periodic surveillance is essential to determine local treatment guidelines. This study was conducted to determine the resistance of N. gonorrhoeae to penicillin, tetracycline, levofloxacin, cefixime and ceftriaxone among the high-risk population for acquiring STIs in Jakarta and to identify factors associated with resistance. Methods: A cross-sectional study was conducted in Jakarta, Indonesia, from September to November 2018. In all, 98 high-risk males and females who fulfilled the study criteria were included. Specimens were collected from urethral or endocervical swabs, put into Amies transport medium and then transported to the Laboratory of Clinical Microbiology, Universitas Indonesia for culture and identification. Proven gonococcal isolates were examined for susceptibility to various antimicrobials using the disk diffusion method according to Clinical and Laboratory Standard Institute guidelines. Results: Of the 98 specimens, 35 were confirmed to be N. gonorrhoeae. The proportion of N. gonorrhoeae specimens resistant to penicillin, tetracycline, levofloxacin, cefixime and ceftriaxone among the high-risk population was 97.1%, 97.1%, 34.3%, 0% and 0% respectively. The possible factors associated with resistance could only be analysed for levofloxacin. Age, sexual orientation and a history of orogenital sexual activity during the past month were not associated with N. gonorrhoeae resistance to levofloxacin. Conclusion: This study detected no resistance of N. gonorrhoeae to cefixime and ceftriaxone. Further studies with larger samples are needed to obtain more representative results of N. gonorrhoeae resistance and the possible factors associated with resistance.

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Surveillance of Antibiotic Susceptibility Patterns of <i>Neisseria gonorrhoeae</i> from 2013 to 2015 in Guangxi Province, China

Cited by 4 publications

References 13 publications

<p>Antimicrobial Resistance And Molecular Characteristics Among Neisseria gonorrhoeae Clinical Isolates In A Chinese Tertiary Hospital</p>

<p>Antimicrobial Resistance And Molecular Characteristics Among Neisseria gonorrhoeae Clinical Isolates In A Chinese Tertiary Hospital</p>

Mechanism of action, resistance, synergism, and clinical implications of azithromycin

Antimicrobial resistance of Neisseria gonorrhoeae in Jakarta, Indonesia: a cross-sectional study

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