Surveillance in the routine management of ulcerative colitis: The predictive value of low-grade dysplasia

Woolrich, Audrey J.; DaSilva, M; Korelitz, Burton I.

doi:10.1016/0016-5085(92)90831-i

Cited by 191 publications

(95 citation statements)

References 12 publications

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“…Several studies support the indication of PC for fLGD [31,33,39,40,48,49,47,58]. Connell et al [41] found that 56% of UC patients with fLGD developed either HGD or carcinoma within 5 years and cancer was found in 22.2% of patients with diagnosed LGD who underwent colectomy.…”

Section: Proctocolectomymentioning

confidence: 94%

“…Multifocal dysplasia is considered an ominous finding [39,44]. Patients with dysplasia may go on to develop invasive carcinoma [36,41,47]. Dysplasia occurs remote from a cancer in 60-73% of cases and 13-40% of patients with cancer do not harbor dysplasia in any region of the colon [48,49,50].…”

Section: Dysplasiamentioning

confidence: 99%

“…Agreement among pathologists for IDD or LGD is low, 50-65% [41,63,66]. About 25% of CC occurs without detectable dysplasia distant to the tumor [14,41,47,48,50,64]. Some reports describe cancer developing after long periods between surveillance examinations; in addition, cancers discovered with dysplasia surveillance are not necessarily identified at early stage [36,39,40,41,47].…”

Section: Surveillancementioning

confidence: 99%

“…About 25% of CC occurs without detectable dysplasia distant to the tumor [14,41,47,48,50,64]. Some reports describe cancer developing after long periods between surveillance examinations; in addition, cancers discovered with dysplasia surveillance are not necessarily identified at early stage [36,39,40,41,47]. In one study, patients progressed to advanced stage cancer while maintaining surveillance schedule of <12 months between examinations [39].…”

Section: Surveillancementioning

confidence: 99%

“…Despite its low predictive value, once dysplasia is found the risk of cancer increases dramatically [,43,43,49,50,65]. There is an association between presence of dysplasia and presence of established cancer and risk of developing HGD or carcinoma within a short period of time [11,39,40,43,47,48,49,58]. Patients with any grade dysplasia are 3-30Â as likely to have invasive cancer somewhere in the colorectum (with a probability of 50-70%) than if they did not have dysplasia [48,49].…”

Section: Proctocolectomymentioning

confidence: 99%

See 4 more Smart Citations

Ulcerative colitis and cancer

Kulaylat

Dayton

2010

Journal of Surgical Oncology

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Patients with ulcerative colitis (UC) are at an increased risk for the development of colorectal cancer (CRC). Unlike sporadic CRC, the cancer in UC patients arises from a focal or multifocal dysplastic mucosa in areas of inflammation. The clinical features of UC-associated cancer are similar to those found in patients with hereditary non-polyposis colorectal cancer. As with other varieties of CRC, UC-associated cancer exhibits a variety of genetic and molecular changes/abnormalities. These abnormalities are however clustered in areas of mucosae with histological abnormalities. The magnitude and timing of these changes are however significantly different. Surveillance and identification of patients at risk for cancer are a challenging problem.

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