Surveillance for portal hypertension in the course of liver cirrhosis

Piekarska, Anna; Berkan, E; Wójcik, Kamila

doi:10.5114/ceh.2018.75954

Cited by 2 publications

(1 citation statement)

References 21 publications

(26 reference statements)

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“…Portal hypertension is a clinical syndrome affecting patients with or without cirrhosis, in which hemodynamic changes in the portosystemic circulation lead to complications such as variceal bleeding, ascites, and portosystemic encephalopathy. [1][2][3] Upper gastrointestinal bleeding caused by esophageal varices is its most serious complication, with an annual bleeding rate of 5-15% and a rebleeding rate of 60% within 1 year. 4 The surgical treatment of portal hypertension primarily aims to prevent esophageal variceal bleeding.…”

Section: Introductionmentioning

confidence: 99%

Efficacy Analysis of Gastric Coronary Venous TH Glue Embolization with Splenectomy for Treating Cirrhotic Portal Hypertension

Li¹,

Wang²,

Chen³

et al. 2019

Exploratory Research and Hypothesis in Medicine

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Background and aims: To evaluate the effects of gastric coronary venous embolization with TH glue (developercontaining octyl-α-cyanoacrylate) in combination with splenectomy for the treatment of cirrhotic portal hypertension and gastroesophageal varices. Methods: From April 2002 to July 2016, 81 patients with cirrhotic portal hypertension who underwent this procedure were subject to perioperative (within 2 weeks), short-term (within 2 weeks to 1 month) and long-term (1 month thereafter) efficacy analyses. Complications, rebleeding rate, and long-term survival rate were evaluated. Results: No patients developed embolism caused by TH glue ectopia. Eleven patients experienced perioperative complications, including high esophageal expenditure blood (1%), subphrenic effusion (1%) and abdominal infection (1%), which affected one case each respectively. Pulmonary infection (2%) and portal system thrombosis (2%) affected two cases respectively. There were 4 patients who experienced ascites (5%). All patients had small amounts of melena and were healed after conservative medical treatment. The 1-, 3-, 5-and 10-year postoperative rebleeding rates were 4.9%, 8.6%, 11.1% and 18.5% respectively. The 1-, 3-, 5-and 10-year postoperative survival rates were 97.5%, 92.6%, 90.1% and 80.2% respectively. No hepatic encephalopathy occurred within 1 year after operation in any case. Conclusions: The postoperative rebleeding rate was lower than that reported in the literature and the subjects achieved good perioperative, short-term and long-term effects. The method of operation in the treatment of cirrhotic portal hypertension and gastroesophageal varices is characterized by a good safety profile, less invasiveness, rapid postoperative recovery, and a lower rebleeding rate than other devascularization procedures. Thus, it is an option that can be first considered by patients requiring emergency surgery to stop bleeding or patients with poor liver function, and even some patients with Child-Pugh grade C.

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Section: Introductionmentioning

confidence: 99%

Efficacy Analysis of Gastric Coronary Venous TH Glue Embolization with Splenectomy for Treating Cirrhotic Portal Hypertension

Li¹,

Wang²,

Chen³

et al. 2019

Exploratory Research and Hypothesis in Medicine

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Hemorheological and biochemical study in patients with liver cirrhosis

et al. 2022

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In this study, rheological techniques are used to measure the flow properties of blood from 52 patients with liver cirrhosis. A comparative analysis included a control group (23 persons) to determine the stage of the disease in cirrhotic patients. An important correlation relating the blood biochemical composition with the rheological response was found. Two rheological techniques were employed: simple shear-flow and small amplitude oscillatory shear. The “whole blood viscosity” (WBV) exhibits non-Newtonian shear-thinning behavior. Cirrhotic patients show low WBV levels as well as low values of viscoelastic response compared to those of the control group. Viscosity curves in decompensated cirrhotic patients tend toward a Newtonian behavior (constant viscosity) at high shear rates. Regarding the complex viscosity, there are clear differences between compensated and decompensated patients. The viscoelastic response reveals a change in the slope of the elastic modulus (G′) with frequency as compared to the response of the control group. In general, blood elasticity was observed to decrease as the disease progresses (i.e., blood tends to become less elastic, becoming a Newtonian fluid in advanced cirrhotic patients). These results represent a promising alternative to evaluate the incidence of cirrhosis in patients using fast, inexpensive, and noninvasive tests to confirm liver cirrhosis diseases.

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Surveillance for portal hypertension in the course of liver cirrhosis

Cited by 2 publications

References 21 publications

Efficacy Analysis of Gastric Coronary Venous TH Glue Embolization with Splenectomy for Treating Cirrhotic Portal Hypertension

Efficacy Analysis of Gastric Coronary Venous TH Glue Embolization with Splenectomy for Treating Cirrhotic Portal Hypertension

Hemorheological and biochemical study in patients with liver cirrhosis

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