Surveillance for hepatobiliary cancers in patients with primary sclerosing cholangitis

Ali, Ahmad H.; Tabibian, James H.; Nasser-Ghodsi, Navine; Lennon, Ryan J.; DeLeon, Thomas; Borad, Mitesh J.; Hilscher, Moira; Silveira, Marina G.; Carey, Elizabeth J.; Lindor, Keith D.

doi:10.1002/hep.29730

Cited by 98 publications

(89 citation statements)

References 44 publications

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“…Patients with PSC are at increased risk for hepatobiliary cancers, especially CCA,31 with recent studies reporting a 10‐year cumulative incidence of 7%‐9% 32, 33, 34. As CCA may present morphologically and clinically as a DS, such lesions must be thoroughly investigated to rule out underlying malignancy.…”

Section: Discussionmentioning

confidence: 99%

Dominant strictures in primary sclerosing cholangitis: A multicenter survey of clinical definitions and practices

Hilscher

Tabibian

Carey

et al. 2018

Hepatology Communications

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Dominant strictures (DSs) of the biliary tree occur in approximately 50% of patients with primary sclerosing cholangitis (PSC) and may cause significant morbidity. Nevertheless, the definition and management of DSs lacks consensus. We aimed to better understand current perceptions and practices regarding PSC‐associated DSs. We conducted an anonymous, 23‐question, survey‐based study wherein electronic surveys were distributed to 131 faculty in the Division of Gastroenterology and Hepatology at the three Mayo Clinic campuses (Rochester, Scottsdale, and Jacksonville) as well as the affiliated practice network. Responses were aggregated and compared, where applicable, to practice guidelines of the American Association for the Study of Liver Diseases and European Association for the Study of the Liver. A total of 54 faculty (41.2%) completed the survey, of whom 24 (44.4%) were hepatologists, 21 (38.9%) gastroenterologists, and 9 (16.7%) advanced endoscopists. One of the major study findings was that there was heterogeneity among participants' definition, evaluation, management, and follow‐up of DSs in PSC. The majority of participant responses were in accordance with societal practice guidelines, although considerable variation was noted. Conclusion: Despite the prevalence and morbidity of DSs in PSC, clinical perceptions and practices vary widely among hepatologists, gastroenterologists, and advanced endoscopists who manage these patients, even within a single health care system. Further studies are needed to address these variations, develop general and evidence‐based consensus, and increase adherence to societal guidelines. (Hepatology Communications 2018;2:836‐844)

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Section: Discussionmentioning

confidence: 99%

Dominant strictures in primary sclerosing cholangitis: A multicenter survey of clinical definitions and practices

Hilscher

Tabibian

Carey

et al. 2018

Hepatology Communications

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“…Retrospective data recently published by Ali et al support the notion that surveillance of hepatobiliary cancer may significantly improve outcome in PSC . Prospective data on CCA surveillance and its impact on the detection of early stage cancer and on patient survival are, however, lacking.…”

Section: Introductionmentioning

confidence: 99%

Follow‐up magnetic resonance imaging/3D‐magnetic resonance cholangiopancreatography in patients with primary sclerosing cholangitis: challenging for experts to interpret

Zenouzi

Liwinski

Yamamura

et al. 2018

Aliment Pharmacol Ther

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“…Current tools for early detection of CCA perform poorly; however, annual screening by hepatobiliary imaging and full ileocolonoscopy is recommended by international guidelines [12]. There is currently a trend away from annual ultrasound-based screening for gallbladder polyps (and hepatocellular cancer in cirrhotic patients) towards the use of magnetic resonance imaging (MRI) and MRC as the annual screening imaging modality of choice [13,14], but the full utility of various screening modalities for early cancer detection in PSC awaits prospective validation [15].…”

Section: Introductionmentioning

confidence: 99%

Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities

Vesterhus

Karlsen

2020

J Gastroenterol

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Surveillance for hepatobiliary cancers in patients with primary sclerosing cholangitis

Abstract: This study demonstrates that HBCa surveillance significantly improves outcomes, including survival, in patients with PSC. (Hepatology 2018;67:2338-2351).

Cited by 98 publications

References 44 publications

Dominant strictures in primary sclerosing cholangitis: A multicenter survey of clinical definitions and practices

Dominant strictures in primary sclerosing cholangitis: A multicenter survey of clinical definitions and practices

Follow‐up magnetic resonance imaging/3D‐magnetic resonance cholangiopancreatography in patients with primary sclerosing cholangitis: challenging for experts to interpret

Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities

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