Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease

Fisk, Marie; McEniery, Carmel M.; Gale, Nichola S.; Mäki-Petäjä, Kaisa; Forman, Julia; Munnery, Margaret; Woodcock-Smith, J.; Cheriyan, Joseph; Mohan, Divya; Fuld, Jonathan; Tal‐Singer, Ruth; Polkey, Michael I.; Cockcroft, John R.; Wilkinson, Ian B.; Investigators, Acct

doi:10.1161/hypertensionaha.117.10151

Cited by 31 publications

(22 citation statements)

References 35 publications

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“…The higher prevalence of masked heart failure with preserved ejection fraction in our COPD patients confirms the current notion that COPD is an independent predictor of vascular damage (Fisk et al, 2018; Neilan et al, 2014). It is associated with increased levels of arterial stiffness and myocardial fibrosis even when no manifest CV disease is observed (Anderson, Lipworth, Rekhraj, Struthers, & George, 2013; Schoos et al, 2013).…”

Section: Discussionsupporting

confidence: 88%

Autonomic dysfunction, cardio‐pulmonary exercise testing and masked heart failure with preserved ejection fraction in non‐severe chronic obstructive pulmonary disease

Cherneva¹,

Денчев

Cherneva

2020

Clin Physio Funct Imaging

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Background Autonomic dysfunction (AD) and cardiopulmonary exercise testing (CPET) parameters have been associated with masked heart failure with preserved ejection fraction (HFpEF) in the general population. Their clinical significance for masked HFpEF in chronic obstructive pulmonary disease (COPD) is however elusive. Aim The aim of the study was to determine the prevalence, correlation and clinical significance of AD and CPET with masked HFpEF, in non‐severe COPD patients, complaining of exertional dyspnoea, without clinically overt cardio‐vascular (CV) comorbidities. Methods and results We applied CPET and echocardiography in 68 COPD subjects. Echocardiography was performed before CPET and 1–2 min after peak exercise. Patients were divided into two groups: patients with and without masked HFpEF. Peak E/e′ – 15 was applied as a cut‐off. Chronotropic incompetence (CI) was assumed if both failure to reach the target heart rate (HR) on exercise and diminished heart rate reserve <80% occurred. Abnormal HR recovery (HRR) was taken if the decline is <12 beats within the first minute after exercise cessation. Univariate regression showed association between masked HFpEF, HRR, VO2, VO2 at AT, oxygen pulse and VE/VCO2 slope. The multivariate regression demonstrated HRR as the only independent predictor of masked HFpEF – (OR 10.28; 95% CI (3.55–29.80)). Conclusion Abnormal HRR is the only independent predictor of masked HFpEF in non‐severe COPD patients. Despite of being associated with masked HFpEF, the lower VO2, lower oxygen pulse, higher VE/VCO2 slope and lower exercise load seem to be the consequences, rather than the triggers for it.

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Section: Discussionsupporting

confidence: 88%

Autonomic dysfunction, cardio‐pulmonary exercise testing and masked heart failure with preserved ejection fraction in non‐severe chronic obstructive pulmonary disease

Cherneva¹,

Денчев

Cherneva

2020

Clin Physio Funct Imaging

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“…48 Several studies and meta-analysis have shown that arterial stiffness is also increased in COPD patients in whom it has been related to the severity of the obstruction, systemic inflammation, and previous history of exacerbations. 49 In a longitudinal study, arterial stiffness increase during COPD exacerbations jointly with serum troponin levels. 50 Of note, arterial stiffness in COPD patients is related to serum levels of SPD, CC-16, and desmosine.…”

Section: Arterial Stiffnessmentioning

confidence: 99%

<p>Insights into Chronic Obstructive Pulmonary Disease as Critical Risk Factor for Cardiovascular Disease</p>

Almagro¹,

Boixeda²,

Díez-Manglano³

et al. 2020

COPD

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In patients with chronic obstructive pulmonary disease (COPD), cardiovascular comorbidities are highly prevalent and associated with considerable morbidity and mortality. This coincidence is increasingly seen in the context of a "cardiopulmonary continuum" rather than being simply attributed to shared risk factors, in particular, cigarette smoking. Both disease entities are centrally linked to systemic inflammation as well as aging, arterial stiffness, and several common biomarkers that led to the development of pulmonary hypertension, left ventricular diastolic dysfunction, atherosclerosis, and reduced physical activity and exercise capacity. For these reasons, COPD should be considered an independent factor of high cardiovascular risk, and efforts should be directed to early identification of cardiovascular disease (CVD) in COPD patients. Assessment of the overall cardiovascular risk is especially important in patients with severe exacerbation episodes, and the same therapeutic target levels for glycosylated hemoglobin, low-density lipoprotein cholesterol (LDL-C), or blood pressure than those recommended by clinical practice guidelines for patients at high cardiovascular risk, should be achieved. In this review, we will discuss the most recent evidence of the role of COPD as a critical cardiovascular risk factor and try to find new insights and potential prevention strategies for this disease.

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“…У структурі етіологічних факторів смертності у пацієнтів з ХОЗЛ третє місце посідають захворювання серцево-судинної системи, у тому числі АГ. Пацієнти з ХОЗЛ мають вищий ризик розвитку кардіоваскулярних подій, порівняно із загальною популяцією [7], при цьому не зрозуміло, чи це пов'язано із спільними факторами ризику, чи ХОЗЛ є незалежним чинником виникнення даних патологій [8].…”

Section: The Clinical Course Of Arterial Hypertension In Patients Witunclassified

The clinical course of arterial hypertension in patients with chronic obstructive pulmonary disease and obesity

Pokrovska¹,

Bochar²,

Sklyarova³

2020

Buk. Med. Herald

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Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease

Abstract: Supplemental Digital Content is available in the text.

Cited by 31 publications

References 35 publications

Autonomic dysfunction, cardio‐pulmonary exercise testing and masked heart failure with preserved ejection fraction in non‐severe chronic obstructive pulmonary disease

Autonomic dysfunction, cardio‐pulmonary exercise testing and masked heart failure with preserved ejection fraction in non‐severe chronic obstructive pulmonary disease

<p>Insights into Chronic Obstructive Pulmonary Disease as Critical Risk Factor for Cardiovascular Disease</p>

The clinical course of arterial hypertension in patients with chronic obstructive pulmonary disease and obesity

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