Surrogate estimates of insulin sensitivity in Chinese diabetic patients and their offspring

Abstract

The Matsuda-DeFronzo index, HOMA %S and FPI are good surrogate estimates of insulin sensitivity in Chinese diabetic subjects and their offspring.

The impact of metabolic syndrome on insulin sensitivity, glucose sensitivity, and acute insulin response after glucose load in early-onset type 2 diabetes mellitus: Taiwan Early-Onset Type 2 Diabetes Cohort Study

“…The results suggest that IR is more severe in Taiwanese EODM than in Korean ODM. According to published data, the average HOMA-IR for type 2 diabetes mellitus patients is in the range of 5 to 9 [23,24], similar to the HOMA-IR values in the present study. This is compatible with the conclusion in our earlier article that EODM has severe defects like adult-onset type 2 diabetes mellitus, but with earlier age of onset [8].…”

Measuring insulin sensitivity in postmenopausal women covering a range of glucose tolerance: comparison of indices derived from the oral glucose tolerance test with the euglycemic-hyperinsulinemic clamp

“…These results were consistent with those of other studies, which showed that fasting plasma insulin and insulin 120-minute indices correlate only mildly with more direct indices of insulin resistance [24,25]. In addition, Kuo et al [26] observed that insulin 120-minute index was less correlated with insulin sensitivity obtained from the euglycemic-hyperinsulinemic clamp in type 2 diabetic subjects than in subjects with NGT, because insulin 120-minute levels mainly reflect impaired insulin secretion. Interestingly, HOMA (derived from fasting measurements) and Matsuda (derived from mean glucose and insulin values obtained after an OGTT) indices showed similarly fair concordance with M/I and were also moderately correlated with it.…”

Polycystic Ovaries Are Common in Women with Hyperandrogenic Chronic Anovulation but Do Not Predict Metabolic or Reproductive Phenotype

“…using the fasting (0 min) and 120-min glucose and insulin concentrations. Whereas it is an oversimplification to label an OGTT as a measure of insulin sensitivity, multiple studies have validated strong correlations between such indices derived from the OGTT with the reference method of euglycemic clamps (23,(31)(32)(33). We did note a borderline significant negative correlation between ovarian volume and fasting glucose levels, suggesting that a larger sample size may have yielded slightly different results.…”