Surrogate‐based visualization and sensitivity analysis of coronary stent performance: A study on the influence of geometric design

Abstract

The main goal of this numerical study is to assess the impact of geometric design perturbations on the performance of a representative coronary stent platform. In this context, first, a design parameterization model was defined for the stent under study. After, a set of metrics characterizing stent performance, namely, vessel injury, radial recoil, bending resistance, longitudinal resistance, radial strength, the risk of fracture, prolapse index, and dogboning were evaluated within the context of a finite element analysis. Afterwards, accurate surrogate models were developed, using the efficient global optimization algorithm, as predictive tools in the execution of tasks that normally require a high number of model evaluations, such as global sensitivity analysis and visualization. In the end, the dependence of the output response surfaces on the geometric parameters was mechanically interpreted, which allowed us to understand the complex interplay that exists between the considered design variables and the defined performance metrics.

Surrogate‐based multi‐objective design optimization of a coronary stent: Altering geometry toward improved biomechanical performance

“…Material‐wise, PROMUS Element stent is constituted by a proprietary platinum‐chromium (PtCr) alloy. Additional details regarding the stent geometric model and material properties can be found in Ribeiro et al 29 …”

“…(A) 3D view of a PROMUS Element‐like stent with Finite Element mesh included; (B) Full planar structure (seven circumferential rings each composed by eight hinges); (C) 2D Repeating unit composed by two connected hinges (with proposed design variables); figure adapted from Ribeiro et al 29 …”

“…Stent was meshed with reduced‐integration continuum elements (C3D8R) in all models. Concerning other parameters, such as geometries, material properties, mechanical contact, boundary and loading conditions, each simulation has its own specificities and they have been previously thoroughly described in Ribeiro et al 29 …”

Design and evaluation of a novel anti-reflux biliary stent with cone spiral valve

“…Flexibility analysis for the anti-reflux biliary stent and a corresponding standard stent without valve was carried out using ABaqus. Similarly to previous studies, 27,39 the moment-curvature curve was adopted to assess the flexibility of the two types of stents quantitatively. Thirteen struts were adopted and the initial outer diameter of stent was 10 mm.…”

“…Currently, simulation technology has been widely used in biomechanical assessments for various endovascular and non-vascular stents. 22–27 Simulation analysis has some superiorities compared with clinical trial, for example time-saving, lower cost, and controllable quantitative operation. This technology can be an effective technical means for the preclinical performance assessments of human body lumen stents.…”