Surgically Resected Esophageal Squamous Cell Carcinoma: Patient Survival and Clinicopathological Prognostic Factors

Jeong, Dong Young; Lee, Kyung Soo; Choi, Ju Young; Chung, Myung Jin; Ye, Min; Kim, Hong Kwan; Shim, Young Mog; Sun, Jong‐Mu

doi:10.1038/s41598-020-62028-5

Cited by 7 publications

(6 citation statements)

References 18 publications

(8 reference statements)

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“… 22 , 23 Previous studies showed that pretreatment 18 F-FDG PET was able to differentiate superficial tumor infiltrations and correlated with clinicopathological prognosis. 24 – 26 18 F-FDG PET also has a clinical usage for prognostic stratification. Duong et al 27 showed that 18 F-FDG PET altered the clinical management in esophageal cancer and enabled superior prognostic stratification over conventional modalities.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Pretreatment Staging With 18F-FDG PET in Esophageal Cancer

Lu¹,

Chiu²,

Tsai

2021

Clin Nucl Med

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Purpose of the Report Without the routine use of 18 F-FDG PET for initial staging of esophageal cancer, it may lead to inaccurate staging and suboptimal treatment. The purpose of this study was to evaluate the prognostic significance of pretreatment 18 F-FDG PET in nonmetastatic esophageal cancer by comparing the survival between patients with and without pretreatment PET. Materials and Methods We selected newly diagnosed esophageal cancer patients without metastasis between 2009 and 2015 from Taiwan Cancer Registry and National Health Insurance Research Database. Pretreatment 18 F-FDG PET staging was determined according to the implementation of PET within 90 days before starting treatment. Overall survival was calculated from the day of treatment initiation to the death from any cause. Survival curves were compared between patients with and without PET staging using the log-rank test. Results Of the 9078 patients included, 1765 (19.4%) and 7313 (80.6%) patients were staged with and without pretreatment PET, respectively. The median follow-up time for all patients and survivors was 1.29 years and 5.46 years, respectively. The pretreatment PET group had a lower risk of death than the no pretreatment PET group (hazards ratio, 0.74; 95% confidence interval, 0.70–0.79; P < 0.001). After adjusting for age, stage, histology, and tumor location, pretreatment PET remained significantly correlated with a lower risk of death (hazards ratio, 0.78; 95% confidence interval, 0.73–0.83; P < 0.001). Conclusions The utilization of pretreatment 18 F-FDG PET for staging in nonmetastatic esophageal malignancy is associated with a lower risk of death even after adjusting for age, stage, histology, and tumor location.

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Pretreatment Staging With 18F-FDG PET in Esophageal Cancer

Lu¹,

Chiu²,

Tsai

2021

Clin Nucl Med

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“…Previous studies have demonstrated that the SUV, MTV, TLG, and ADC may be valuable prognostic factors for esophageal cancer ( 10 , 20 ). However, whether these parameters can be used for the prediction of the pathological stage is still controversial.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies revealed 18 F-FDG PET/MRI to be superior to PET/CT in T staging and at least comparable to PET/CT in N and M staging of a variety of tumors ( 8 , 9 ). In addition, imaging parameters such as the standardized uptake value (SUV) and apparent diffusion coefficient (ADC) of tumors may correlate with staging and prognosis ( 10 ). Preliminary studies showed that PET/MRI may overcome the inherent limitations of PET/CT and CT in T staging of esophageal cancer, and has advantages over other imaging methods in N staging ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Value of 18F-FDG PET/MRI in the Preoperative Assessment of Resectable Esophageal Squamous Cell Carcinoma: A Comparison With 18F-FDG PET/CT, MRI, and Contrast-Enhanced CT

Wang

Guo²,

Zhang³

et al. 2022

Front. Oncol.

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ObjectivesTo investigate the value of 18F-FDG PET/MRI in the preoperative assessment of esophageal squamous cell carcinoma (ESCC) and compare it with 18F-FDG PET/CT, MRI, and CECT.MethodsThirty-five patients with resectable ESCC were prospectively enrolled and underwent PET/MRI, PET/CT, and CECT before surgery. The primary tumor and regional lymph nodes were assessed by PET/MRI, PET/CT, MRI, and CECT, respectively, and the diagnostic efficiencies were determined with postoperative pathology as a reference standard. The predictive role of imaging and clinical parameters on pathological staging was analyzed.ResultsFor primary tumor staging, the accuracy of PET/MRI, MRI, and CECT was 85.7%, 77.1%, and 51.4%, respectively. For lymph node assessment, the accuracy of PET/MRI, PET/CT, MRI, and CECT was 96.2%, 92.0%, 86.8%, and 86.3%, respectively, and the AUCs were 0.883, 0.745, 0.697, and 0.580, respectively. PET/MRI diagnosed 13, 7, and 6 more stations of lymph node metastases than CECT, MRI, and PET/CT, respectively. There was a significant difference in SUVmax, TLG, and tumor wall thickness between T1-2 and T3 tumors (p = 0.004, 0.024, and < 0.001, respectively). Multivariate analysis showed that thicker tumor wall thickness was a predictor of a higher T stage (p = 0.040, OR = 1.6).Conclusions18F-FDG PET/MRI has advantages over 18F-FDG PET/CT, MRI, and CECT in the preoperative assessment of primary tumors and regional lymph nodes of ESCC. 18F-FDG PET/MRI may be a potential supplement or alternative imaging method for preoperative staging of ESCC.

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“…Number of cases Negative, n (%) Positive, n (%) (17) and hazard ratio (HR) and log-rank P-value were calculated. P<0.05 was considered to indicate a statistically significant difference.…”

Section: Cin85 Expression -------------------------------------------mentioning

confidence: 99%

High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma

et al. 2020

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SH3 domain-containing kinase-binding protein 1 (CIN85), an 85 kDa protein known to be a member of the signal adaptor family, is abnormally expressed in several human malignancies and has been found to be involved in the growth, migration and invasion of these tumors. The objective of the present study was to clarify the clinical significance of CIN85 in human esophageal squamous cell carcinoma (ESCC), as well as its in vitro functions. CIN85 expression was evaluated in 129 cases of ESCC and its adjacent normal tissues using immunohistochemistry to explore its clinical relevance and prognostic value. The functions of CIN85 in the ESCC TE1 cell line were analyzed in vitro using the interfering short hairpin RNA silencing technique. MTS, wound healing, clone formation and Transwell assays were used to detect the proliferation, migration and invasion of ESCC cells. CIN85 expression was identified mainly in ESCCs and their adjacent normal tissues, and the high expression of CIN85 was significantly associated with advanced Tumor Node Metastasis stage and lymph node metastasis. CIN85 gene silencing significantly inhibited TE1 cell proliferation, migration and invasion. These results demonstrated that CIN85 was highly expressed in advanced stage ESCC and lymph node metastasis, and played a critical role in tumor proliferation and progression. Therefore, CIN85 may be a promising therapeutic target for human ESCC.

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Surgically Resected Esophageal Squamous Cell Carcinoma: Patient Survival and Clinicopathological Prognostic Factors

Abstract: We aimed to report patients' survival after surgical resection of eScc and to ascertain the clinical, imaging, and pathological factors related to patient prognosis. This retrospective study included 435 patients with eScc of Show more

Cited by 7 publications

References 18 publications

Prognostic Significance of Pretreatment Staging With 18F-FDG PET in Esophageal Cancer

Prognostic Significance of Pretreatment Staging With 18F-FDG PET in Esophageal Cancer

Value of 18F-FDG PET/MRI in the Preoperative Assessment of Resectable Esophageal Squamous Cell Carcinoma: A Comparison With 18F-FDG PET/CT, MRI, and Contrast-Enhanced CT

High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma

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