Surgical Wound Infection by <i>Streptococcus pneumoniae</i> After a Cat-Scratch Disease

Savini, Vincenzo; Cecinati, Valerio; Onofrillo, Daniela; Consilvio, Nicola Pietro; Polilli, Ennio; Crescenzi, Carlo; Fazii, Paolo; D’Antonio, Domenico

doi:10.1177/1534734612463702

Cited by 5 publications

(2 citation statements)

References 4 publications

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“…El origen de las IPPBs neumocócicas no se conoce bien. Se ha especulado que puedan estar relacionadas con contaminaciones de origen respiratorio del propio paciente, de sus cuidadores o del personal sanitario [9,10]. Otros autores sugieren la diseminación del microorganismo desde un foco respiratorio a través del tejido celular subcutáneo hasta la piel, o la diseminación hematógena hasta estructuras musculoesqueléticas, produciéndose celulitis en las zonas adyacentes [11].…”

Section: Materials Y Métodosunclassified

Skin and soft tissue infection caused by Streptococcus pneumoniae: report of 15 cases

Madrid¹,

Rodrigo²,

Tena³

2021

Rev Esp Quimioter

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Background. Streptococcus pneumoniae is a very rare cause of skin and soft tissue infections (SSTI). The aim of this study was to determine the clinical and microbiological characteristics of these infections. Material and methods. The medical records of patients with SSTIs due to S. pneumoniae diagnosed at the University Hospital of Guadalajara between January 2012 and December 2020 were retrospectively reviewed. Microbiological identification was performed using conventional procedures. Antimicrobial sensitivity was performed using the MicroScan WalkAway-96 plus automatic system and E-test strips following the recommendations of the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Results. Fifteen cases of SSTIs were diagnosed. 73,3% of the cases presented underlying diseases, neoplasias being the most frequent. 60% of the cases presented predisposing factors, immunosuppression being the most common. The clinical presentations were: abscesses in different locations, ulcers, surgical wounds, lactational mastitis and necrotizing fasciitis. Polymicrobial infections were detected in 73.3% and the etiology was nosocomial in 6.6%. The clinical course was favorable in 90.9% of the cases. The antibiotics with the highest percentages of sensitivity against S. pneumoniae were cefotaxime, levofloxacin, vancomycin, linezolid and rifampicin. Conclusions. S. pneumoniae should be kept in mind as a possible causative agent of SSTIs, especially in patients with neoplasias and immunosuppression. Its involvement in infections such as lactational mastitis and necrotizing fasciitis should be highlighted. The clinical evolution is favorable in most patients, but it is important to pay special attention to cases of necrotizing fasciitis due to the severity of these infections.

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Section: Materials Y Métodosunclassified

Skin and soft tissue infection caused by Streptococcus pneumoniae: report of 15 cases

Madrid¹,

Rodrigo²,

Tena³

2021

Rev Esp Quimioter

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“…Rapid increase of non-vaccine serotypes in carriage and pneumococcal infections has become a great concern for physicians (9). In addition to meningitis due to S. pneumoniae, pneumococcal infections such as surgical wound infection are reported (10). Therefore, other methods of bacterial growth inhibition are being considered.…”

Section: Introductionmentioning

confidence: 99%

Effect of Xylitol on the Growth and Survival of Streptococcus pneumoniae

Asgari

Ataee

Ghorbanalizadegan

et al. 2018

Jundishapur J Microbiol

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Background: Xylitol has been applied in dentistry to prevent dental caries for many years. However, it's anti-Streptococcus pneumoniae effects are unclear. Objectives: The aim of this study was to determine the anti-Streptococcus pneumoniae activity of xylitol. Methods: In this study, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of xylitol were determined by microdilution method and tetrazolium salt-based colorimetric (MTT) assay. The effective concentrations of xylitol in the presence and absence of fructose against growth and survival of S. pneumoniae were measured. Data were analyzed using univariate analysis and Kruskal-Wallis test. Results: The results showed that 5% to 7.5% concentrations of xylitol were associated with reduced number of S. pneumoniae cells. About 80% to 100% of S. pneumoniae cells were killed under laboratory conditions after 3 to 7 hours, respectively. MIC and MBC of xylitol against S. pneumoniae were 2.5% and 7.5% after 4 hours, respectively. We found significant changes in the number of viable cells (P ≤ 0.002). Conclusions:The results showed that the 5% and 7.5% concentrations of xylitol inhibit S. pneumoniae growth. However, the emergence of multi-drug resistance in S. pneumoniae has become a global concern and the S. pneumoniae 23-valent vaccine may not be able to protect against S. pneumoniae human pathogenic strains. Finding a non-related antibiotic agent may be useful for controlling S. pneumoniae infections.

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