Surgical vs nonsurgical jaundice. Differentiation by a combination of rose bengal I-131 and standard liver-function tests

Nordyke, Robert A.

doi:10.1001/jama.194.9.949

Cited by 19 publications

(5 citation statements)

References 11 publications

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“…This method was also adopted by Garcia et al (1959) andSchuman et al (1963), but again considerable overlap was found between the various categories in these reports, which may have been due to the fact that in conditions of hepatocellular impairment, extrahepatic uptake of bromsulphthalein occurs (Jones et al, 1961 ;Freeman et al, 1968), and therefore blood disappearance of I3lI Rose Bengal may not strictly parallel hepatic uptake. A later series by Nordyke (1965) reported an 80 per cent accuracy in the differentiation of 'medical' from 'surgical' jaundice using this technique, but no mention was made of distinction between extrahepatic obstructive jaundice and intrahepatic cholestasis, as their series contained none of the latter group of patients.…”

Section: Discussionmentioning

confidence: 99%

The value of the radio-isotope hepatogram in the jaundiced patient

Watson

Bone

Testa

et al. 1975

Journal of British Surgery

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The distinction between 'medical' and 'surgical' jaundice is often difficult due to the lack of specificity of biochemical liver function tests, and the difficulty in assessing hepatocellular function and biliary tract patency in the jaundiced patient. We present a noninvasive isotopic technique which gives reliable information on these parameters, resulting in a high degree of accuracy in the classification of jaundice. 131I Rose Bengal, which is handled by the liver like bromsulphthalein, is administered intravenously and count rates during hepatic uptake and biliary excretion are recorded over the liver, biliary tract and duodenum using a gamma camera/computer system, into which is built an electronic light pen, so that particular areas of interest can be studied. Blood clearance of the iostope is simultaneously measured, and from these data the T 1/2 of uptake, the plasma retention and the excretion quotient are determined. The results of the first 80 examinations show that by qualitative assessment of the uptake and excretory phases of the 'hepatogram' and by determination of the T 1/2 and excretion quotient, jaundice has been classified with an 86 per cent accuracy in cases where the diagnosis is not apparent from clinical and biochemical data. The T 1/2 of uptake correlates well with bromsulphthalein retention in the non-jaundiced patient, and when applied to patients with obstructive jaundice enables the progress of hepatocellular impairment with time to be studied, and its recovery after relief of the obstruction. Preliminary results suggest that the technique may also have applications in the study of biliary tract dynamics in patients with post-cholecystectomy syndromes and relapsing acute pancreatitis.

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Section: Discussionmentioning

confidence: 99%

The value of the radio-isotope hepatogram in the jaundiced patient

Watson

Bone

Testa

et al. 1975

Journal of British Surgery

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“…RB has an intersystem crossing quantum yield approaching unity (F isc ¼ 0.98) and a high singlet oxygen yield (r( 1 O 2 *) > 0.75), indicating that RB is capable of highly efficient 1 O 2 * production upon irradiation with green light [8]. Its long history of safe use as a systemic diagnostic of hepatic function [9][10][11][12][13][14][15][16][17][18][19][20][21] as well as a topical ophthalmic diagnostic [22][23][24][25][26][27][28] suggests that, in marked contrast to many photodynamic therapy (PDT) agents, RB should have minimal potential for side effects, such as prolonged photosensitivity.…”

Section: Introductionmentioning

confidence: 99%

Topical rose Bengal: Pre‐clinical evaluation of pharmacokinetics and safety

Wachter¹,

Dees²,

Harkins³

et al. 2003

Lasers Surg Med

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“…E HOMO indicates the ability to donate electrons while E LUMO indicates the ability to accept electrons during electronic transitions. The definition for ionization energy (I) and electron affinity (A) based on the HOMO-LUMO energy gap as I = −E HOMO and A = −E LUMO ; were involved in Koopman's theorem [21][22]31]. Softness (S) had been computed as the half of reciprocal of hardness (η) and η = (I − A)/2; while the chemical potential (μ) and electronegativity (χ) can was calculated from FMOs analysis as follows: μ = −(I + A)/2 and χ = (I + A)/2 [24].…”

Section: Fig 9 Relation Between E Homo E Lumo and E Gap Of Piog (mentioning

confidence: 99%

“…It has absorption coefficient in the visible region and a high tendency for inter-system crossing to produce a photochemically active triplet excited state due to its photo-activity [16]. RBeng had been used as a photodynamic sensitizer for cancer chemotherapy [19][20][21][22]. It also used as a topical ophthalmic diagnostic by Argueso et al, 2006 [23].…”

Section: Introductionmentioning

confidence: 99%

Rose bengal- Pioglitazone drug reaction novel products. Structures – biological activity and cytotoxicity relationship and evaluation with theoretical calculations.

2019

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T HE PIOG-RBeng reaction novel products were characterized by thermal in comparison with spectroscopic data using FT-IR, 1 H-NMR, then confirmed by XRD measurements and Theoretical computational calculations. The software of Gaussian 09W package had been used for computations. The geometries of Rose bengal (RBeng), Pioglitazone (PIOG) drug and their reaction products were optimized using B3LYP method and (DFT)/GENECP level was obtained by using Def2TZVP basis set. The basis set 6-311++G (d, p) had been used for remainder atoms. The mixed basis set was used due to its flexibility. HOMO and LUMO energy values, chemical hardness and electronegativity had been calculated for compounds. NBO calculations were made for measurement qualitatively the intra-molecular delocalization in systems under investigation on the same level using (NBO 3.1) program implanted in Gaussian 09W.The theoretical calculations involved estimation of global reactivity descriptors, local descriptors and molecular electrostatic potential (MEP) maps. TD-DFT approximation was used to calculate the FT-IR and 1 HNMR spectra of the studied compounds; which actually compared with practical data. Successful correlation between experimental and theoretical calculations had been made to confirm structures of studied compounds. The X-ray diffraction (XRD) was used to study the crystallographic structures of compounds under investigation. The practical results are also correlated to theoretical calculations of electronegativity (X), polarizability, HOMO and LUMO values of PIOG and PIOG-RBeng reaction products. The vibrational frequencies were evaluated in comparison with the corresponding normal modes at the optimized geometry. The investigated compounds are highly effective against Hepatocellular carcinoma, Breast carcinoma and Colon carcinoma cells. It is concluded that; cancer cells over expression promotes tumorigenic functions; can be suppressed by reaction products inhibitors.

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Surgical vs nonsurgical jaundice. Differentiation by a combination of rose bengal I-131 and standard liver-function tests

Cited by 19 publications

References 11 publications

The value of the radio-isotope hepatogram in the jaundiced patient

The value of the radio-isotope hepatogram in the jaundiced patient

Topical rose Bengal: Pre‐clinical evaluation of pharmacokinetics and safety

Rose bengal- Pioglitazone drug reaction novel products. Structures – biological activity and cytotoxicity relationship and evaluation with theoretical calculations.

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