Surgical Treatments and Prognoses of Patients with Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Abstract

Patients with combined hepatocellular carcinoma and cholangiocarcinoma had poor postoperative survival rates. High CA 19-9 level was associated with poorer survival, suggesting that the cholangiocarcinoma portion may be a major determining factor for patient prognosis. Aggressive surgical treatment, including lymph node dissection, may improve survival in patients suspected of or diagnosed with these tumors.

Mixed hepatocellular and cholangiocarcinoma: a rare tumor with a mix of parent phenotypic characteristics

“…[4][5][6][7] Most literature on this topic is descriptive in nature, consisting of case reports and small series. Consequently, data regarding surgical outcomes for cHCC-CCA are limited.…”

Combined hepatocellular and cholangiocarcinoma associated with hepatolithiasis: Report of a case

“…Previously reported data suggested that the etiologic factors responsible for cHCC-CC are quite similar to classical HCC. 3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18] However, our case exhibited a different cause -effect relationship from that reported in the literature, with a previous history of acquired biliary abnormality and hepatolithiasis. Abnormalities of the biliary tree and hepatolithiasis are the well-known risk factors for CC.…”

“…Hepatitis C infection is the second most common risk factor for the development of cHCC-CC. 3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18] However, the association of viral hepatitis with cHCC-CC was lower than for HCC and higher than for CC. 19 Etiologic factors with a weaker association include alcohol consumption, liver fl ukes, and genetic hemochromatosis.…”

A Case of Curative Resection of Advanced Combined Hepatocellular-cholangiocarcinoma after Neoadjuvant Chemotherapy

“…However, commonly combined liver cirrhosis has the potential for serious complications, so strict selection of patients is required, taking into consideration any pre-existing cirrhosis, general physical condition, tumor extent as examples (6,11,12). Currently, aggressive treatments including liver transplantation have been attempted on cHCC-CC patient (13).…”