Abstract:Nonmelanotic skin cancers (NMSCs) are the most frequent of all neoplasms and nasal pyramid represents the most common site for the presentation of such cutaneous malignancies, particularly in sun-exposed areas: ala, dorsum, and tip. Multiple options exist to restore functional and aesthetic integrity after skin loss for oncological reasons; nevertheless, the management of nasal defects can be often challenging and the best “reconstruction” is still to be found. In this study, we retrospectively reviewed a tota… Show more
“…For many cancer types, such as some hematologic tumors, chemotherapy is the most effective treatment ( Mousavi et al, 2016 ; Bell et al, 2018 ). For other types, surgery is the best option ( Marcasciano et al, 2017 ; Ye et al, 2017 ); when surgery is not possible, chemotherapy can be helpful in stopping tumor growth or reducing its volume ( Wagner et al, 2017 ; Wang et al, 2018 ). Unfortunately, in many cases antitumor drugs are not effective and they often have deleterious side effects ( Iwamoto et al, 2014 ; Li and Caeyenberghs, 2018 ).…”
Melatonin is an endogenous indoleamine with an incredible variety of properties and activities. In recent years, an increasing number of studies have investigated this indoleamine’s interaction with cancerous cells. In particular, it seems that melatonin not only has the ability to improve the efficacy of many drugs used in chemotherapy but also has a direct inhibitory action on neoplastic cells. Many publications underlined the ability of melatonin to suppress the proliferation of various cancer cells or to modulate the expression of membrane receptors on these cells, thereby reducing tumor aggressiveness to metastasize. In addition, while melatonin has antiapoptotic actions in normal cells, in many cancer cells it has proapoptotic effects; these dichotomous actions have gained the interest of researchers. The increasing focus on melatonin in the field of oncology and the growing number of studies on this topic require a deep understanding of what we already know about the antineoplastic actions of melatonin. This information would be of value for potential use of melatonin against neoplastic diseases.
“…For many cancer types, such as some hematologic tumors, chemotherapy is the most effective treatment ( Mousavi et al, 2016 ; Bell et al, 2018 ). For other types, surgery is the best option ( Marcasciano et al, 2017 ; Ye et al, 2017 ); when surgery is not possible, chemotherapy can be helpful in stopping tumor growth or reducing its volume ( Wagner et al, 2017 ; Wang et al, 2018 ). Unfortunately, in many cases antitumor drugs are not effective and they often have deleterious side effects ( Iwamoto et al, 2014 ; Li and Caeyenberghs, 2018 ).…”
Melatonin is an endogenous indoleamine with an incredible variety of properties and activities. In recent years, an increasing number of studies have investigated this indoleamine’s interaction with cancerous cells. In particular, it seems that melatonin not only has the ability to improve the efficacy of many drugs used in chemotherapy but also has a direct inhibitory action on neoplastic cells. Many publications underlined the ability of melatonin to suppress the proliferation of various cancer cells or to modulate the expression of membrane receptors on these cells, thereby reducing tumor aggressiveness to metastasize. In addition, while melatonin has antiapoptotic actions in normal cells, in many cancer cells it has proapoptotic effects; these dichotomous actions have gained the interest of researchers. The increasing focus on melatonin in the field of oncology and the growing number of studies on this topic require a deep understanding of what we already know about the antineoplastic actions of melatonin. This information would be of value for potential use of melatonin against neoplastic diseases.
“…Reconstruction with locoregional flaps was performed in all cases. Accurate evaluation of the patients clinical condition and local defect should be always considered in order to select the best surgical option [1].…”
There is no perfect method of nasal reconstruction. All reconstruction types have advantages and disadvantages equally. Perhaps, the personalized medicine can be best illustrated by this surgical pathology. The present paper describes our experience with locoregional fasciocutaneous flaps together with cartilage grafts as surgical treatment for patients with nasofacial cutaneous tumors. After describing the general conditions for the 12 patients included in the study we presented the surgical management of an old woman with a nasal tumor (basal cell carcinoma) of 50/40/35 mm. Favorable results (from aesthetic and functional point of view) were obtained for most patients included in the study. There was only one recurrence, at 1 year postoperatively to the patient diagnosed with malignant melanoma. Considering the etiopathogenetic mechanisms of nasofacial cutaneous tumors and the other nasal reconstruction procedures, more extensive and multicenter studies are needed.
“…The search of the literature revealed that satisfactory reconstruction of the columella is possible through several techniques (Marcasciano et al, ; Margulis et al, ). For skin‐only columellar defects, skin grafts are a reasonable reconstructive method.…”
Section: Discussionmentioning
confidence: 99%
“…The choice of the reconstructive method should also address a color match and texture, minimizing donor site morbidity. The search of the literature revealed that satisfactory reconstruction of the columella is possible through several techniques (Marcasciano et al, 2017;Margulis et al, 2013). For skin-only columellar defects, skin grafts are a reasonable reconstructive method.…”
The columella is one of the smallest subunits of the nose, but the loss of this structure has important aesthetic and structural implications. Few papers in literature present microsurgical techniques for the reconstruction of an isolated columellar defect. This report describes the use of a prelaminated radial forearm free flap (RFFF) for the reconstruction of an isolated columellar defect and reviews the current literature. A 45‐year‐old woman presented to our Unit with a history of palate squamous cell carcinoma and severe nasal deformity with an almost complete loss of the columella. A prelaminated RFFF with the fifth rib was used for a two‐staged reconstruction of the isolated columellar defect. The radial pedicle was anastomosed to the facial vessels and the postoperative course was uneventful. Complete survival of the flap was achieved and, 10 months postoperatively, the patient had bilateral nasal patency, with an increased tip projection and a good aesthetic result. A prelaminated RFFF can be considered a valuable reconstructive option in cases of a large composite defect of the columella and limited availability of adjacent tissues.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.