Surgical treatment strategy for hepatocellular carcinoma in patients with impaired liver function: hepatic resection or radiofrequency ablation?

Yamao, Takanobu; Imai, Katsunori; Yamashita, Yo‐ichi; Nakagawa, Shigeki; Mima, Kosuke; Hashimoto, Daisuke; Chikamoto, Akira; Ishiko, Takatoshi

doi:10.1016/j.hpb.2017.08.031

Cited by 10 publications

(1 citation statement)

References 33 publications

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“…Various treatments have been developed for HCC, with the selection of appropriate regimens usually based on specific patient factors, such as liver function reserve, and tumor factors, such as tumor diameter and number of intrahepatic tumors (8,9). In the HCC treatment algorithm described in the current Japanese Clinical Practice Guidelines (10), hepatectomy and radiofrequency ablation (RFA) are recognized as two of the most radical treatments (11).…”

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confidence: 99%

Prognostic Significance of Treatment Strategies for the Recurrent Hepatocellular Carcinomas After Radical Resection

Saito

Amemiya

Hosomura

et al. 2020

In Vivo

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Background/Aim: The high rate of recurrence and repetitive features of hepatocellular carcinoma (HCC) require specific treatment strategies. This study aimed to evaluate the long-term outcomes of recurrent HCC focusing on clinicopathological factors. Patients and Methods: A total of 104 patients who were treated with re-hepatectomy, radiofrequency ablation (RFA) or transcatheter arterial chemoembolization for recurrent HCC were analyzed. Postrecurrent prognoses were compared between each treatment group based on the presence of adverse prognostic factors (APFs) identified. Results: In the hepatectomy group, the prognosis of patients with APFs was significantly worse compared to those without APFs. By contrast, the survival rate of patients who underwent RFA was not significantly different from those with and without APFs. Conclusion: Our results demonstrate the heterogeneity that exists in terms of the longterm survival of patients with recurrent HCC. The treatment strategy for recurrent HCC should be based on the assessment of presence of APFs to improve long-term prognosis.

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confidence: 99%