Surgical Treatment Outcomes of Patients with Conus Medullaris Teratoma: A Single-Center Experience of 39 Patients

Chen, Yakun; Li, Ze; Chen, Xin; Yin, Yong; Qiao, Guangyu

doi:10.1016/j.wneu.2020.07.148

Cited by 1 publication

(5 citation statements)

References 58 publications

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“…For instance, in their study of patients with 39 conus medullaris teratomas, Chen and colleagues reported that bladder and bowel dysfunction were the most common symptoms (76.9%), even more prevalent than lower back/leg pain (59.0%). 12 Similar to these reports, our case suffered from prolonged urinary incontinence. These findings are foreseeable as the sympathetic innervation of the bladder originates in the lower thoracic and upper lumbar segments of the spinal cord, 13 and the presence of urinary manifestations might be suggestive of a lesion in the conus medullaris.…”

Section: Discussion and Review Of The Literaturesupporting

confidence: 87%

“…The presence of the tumor in the conus medullaris region is associated with other characteristic symptoms, including bladder sphincter or sexual disturbances. For instance, in their study of patients with 39 conus medullaris teratomas, Chen and colleagues reported that bladder and bowel dysfunction were the most common symptoms (76.9%), even more prevalent than lower back/leg pain (59.0%) 12 . Similar to these reports, our case suffered from prolonged urinary incontinence.…”

Section: Discussion and Review Of The Literaturesupporting

confidence: 86%

“…Similar to our observations, some reports have also indicated that tumor removal resulted in improvement of back pain and leg weakness, while urinary symptoms persisted after the surgery. 25 In a case series of 39 patients with conus medullaris teratoma, Chen et al 12 reported that neurological outcomes were improved in 45.7% of the cases and were stable in 40% of the patients, while in 14.3% these symptoms were aggravated.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

“…Ependymomas also demonstrate heterogeneous signals on T1‐ and T2‐weighted images. However, the hemorrhagic or necrotic regions seen in ependymomas are uncommon in teratomas 12 . Overall, histopathologic examination is considered a definitive measure of diagnosis.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

“…However, the hemorrhagic or necrotic regions seen in ependymomas are uncommon in teratomas. 12 Overall, histopathologic examination is considered a definitive measure of diagnosis. Accordingly, teratomas are typically diagnosed based on the presence of all three germ layers; however, it has been proposed that determining the total number of layers can be challenging in some instances, as one or two germ layers may grow excessively.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

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Mature teratoma of conus medullaris: A case report and review of literature

Eslami,

Ilaghi,

Shahabinejad

et al. 2023

Clinical Case Reports

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Key Clinical MessageIn conus medullaris, mature teratomas are rare. We report a case of a 40‐year‐old man who presented with urinary incontinence, low back pain, and muscle weakness. Magnetic resonance imaging revealed a mass in conus medullaris (T11–L1), further confirmed as a mature teratoma by pathological examination. We identified 63 cases of conus medullaris teratoma over the past two decades by systematically analyzing the case reports. Findings demonstrated that most cases were diagnosed in the fourth decade of life, with the majority of cases (57.6%) being male. Lower back pain, radiating pain in the extremities, hypoesthesia, and urinary dysfunction are the most common clinical presentations among patients with teratoma of conus medullaris. Mature teratoma is the dominant pathologic subtype of teratomas in this region, comprising more than 95% of cases. Our case highlights the importance of considering spinal teratoma as a differential diagnosis in patients presenting with urinary incontinence and lumbar pain.

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Section: Discussion and Review Of The Literaturesupporting

confidence: 87%

Section: Discussion and Review Of The Literaturesupporting

confidence: 86%