Surgical Treatment of the Patients with Cervical Disc Herniation at Clinical Center of University of Sarajevo, Bosnia and Herzegovina

Sefo, Haso; Ahmetspahić, Adi; Hajdarpašić, Edin; Barucija, Mersad; Muftić, Mirsad

doi:10.5455/medarh.2021.75.116-121

Med Arch

2021

DOI: 10.5455/medarh.2021.75.116-121

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Surgical Treatment of the Patients with Cervical Disc Herniation at Clinical Center of University of Sarajevo, Bosnia and Herzegovina

Haso Sefo

Adi Ahmetspahić

Edin Hajdarpašić

et al.

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2024

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Cited by 3 publications

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Evaluation of the component’s contribution in endothelium-dependent acetylcholine-induced relaxation of the rat aorta

Mezhenskyi,

Philyppov

2024

Fiziol Zh

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The regulation of rat aorta vascular tone involves various factors, including endothelium-derived hyperpolarization factor (EDHF), nitric oxide (NO), prostaglandins, and sensory nerves. While these elements can function independently, their pathways intersect at various points, complicating the assessment of their individual contributions. The aim of this study was to establish the numerical contributions of EDHF, NO, prostaglandins, and also the effect of the sensory nerve on acetylcholine-induced relaxation on the background of phenylephrine preconstriction using contraction and relaxation measurements in Wistar rat thoracic aorta. EDHF, whose action is mediated through potassium channels, emerges as a crucial regulator. Blockage of inward rectifier potassium (KIR) channels integral to EDHF significantly abolishes 50% of the relaxation amplitude in comparison to control conditions. Endothelial TRPV4 channel, exhibiting a fine-tuning role, contributes to a 25% reduction in the amplitude of acetylcholine-induced relaxation in comparison to control relaxation. NO demonstrates its vasodilatory prowess, with NO blockage eliminating 77% of the residual relaxation effect after KIR blockage. Blockage of prostaglandin functions, modulated by cyclooxygenase 1, reduces relaxation by 44% in comparison to control relaxation. Desensitization of sensory nerves with capsaicin, shows a minor yet significant role, in the reduction of acetylcholine-induced relaxation amplitude by 10%. In conclusion, we established that the main element of acetylcholine-induced relaxation is EDHF with approximately 50% of relaxation amplitude depending on it.

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Evaluation of the component’s contribution in endothelium-dependent acetylcholine-induced relaxation of the rat aorta

Mezhenskyi,

Philyppov

2024

Fiziol Zh

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Scales for assessing neurological disorders and degenerative changes in the cervical spine. Literature review

Samoylov,

Semenov,

Sorokovikov

et al. 2024

Bulletin of Neurology, Psychiatry and Neurosurgery

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More than sixty scales have been developed for the diagnosis and treatment of degenerative pathology of the cervical spine from the perspective of neurological syndromes. The use of most of these in clinical practice is limited. The purpose of this study is to highlight the most popular scales for assessing degenerative changes of the cervical spine from the perspective of neurological syndromes in the diagnosis and determination of treatment tactics for single-segment stenosis of the spinal canal at the cervical level. The current clinical guidelines “Degenerative Spine Diseases” 2021 use the Neck Disability Index, the Visual Analog Scale, and the Frankel Grade among all scales. MEDLINE (PubMed) and Google Scholar were searched from 1972 to 2023 using the key words “cervical spine degeneration”. The initial search identified more than 13,000 articles. This review included 52 studies in which the analysis of clinical and neurological data was carried out using scoring scales for assessing neurological syndromes and functional status in degenerative spinal stenoses at the cervical level. The validity, reliability, and applicability of the scales in clinical practice were analyzed and compared. Based on the analysis of literature data, the most rational scales to use from the standpoint of validity, reliability, and time consumption are the Visual Analog Scale for pain assessment, the Neck Disability Index for assessing cervical radiculopathy, the European Myelopathy Score to assess cervical myelopathy, the Neck Pain and Disability Scale to assess functional outcomes, and the Hospital Anxiet y and Depression Scale for mental status assessment.

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Comparison of Cervical Cage and Cervical Disc Prosthesis in Cervical Disc Herniation: A Single-Center Study

Altınel,

Limnili,

Özcan Söylev

et al. 2024

jtss

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Surgical Treatment of the Patients with Cervical Disc Herniation at Clinical Center of University of Sarajevo, Bosnia and Herzegovina

Cited by 3 publications

References 10 publications

Evaluation of the component’s contribution in endothelium-dependent acetylcholine-induced relaxation of the rat aorta

Evaluation of the component’s contribution in endothelium-dependent acetylcholine-induced relaxation of the rat aorta

Scales for assessing neurological disorders and degenerative changes in the cervical spine. Literature review

Comparison of Cervical Cage and Cervical Disc Prosthesis in Cervical Disc Herniation: A Single-Center Study

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