Surgical Treatment of Squamous Cell Carcinoma of the Oral Tongue: Factors Influencing Survival

Whitehurst, John O.; Droulias, C

doi:10.1001/archotol.1977.00780210068007

Cited by 112 publications

(62 citation statements)

References 17 publications

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“…Fragmentation of cMAb U36 to F(ab') 2 and Fab' fragments was performed by GenScript (GenScriGenScript USA Inc., Piscataway, NJ, USA). The products were purified using protein A and analyzed with non-reducing SDS-PAGE.…”

Section: Methodsmentioning

confidence: 99%

“…The presence or absence of lymphatic and distant metastases has a major impact on the preferred treatment and expected survival (2). FDG-PET, in addition to morphological diagnostics, is a valuable tool in the management of head and neck cancers, being superior to CT and MRI in the staging of lymph nodes (3).…”

Section: Introductionmentioning

confidence: 99%

“…In this study the novel F(ab') 2 and Fab' fragments derived from cMAb U36 were radiolabeled with 125 I and the conjugates were first characterized in vitro for binding specificity, affinity, as well as yield, purity and stability of radiolabelling. The biodistribution of radiolabeled cMAb U36 and its F(ab') 2 and Fab' fragments was then evaluated in nude mice with CD44v6-expressing UT-SCC7 HNSCC tumors.…”

Section: Introductionmentioning

confidence: 99%

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A novel CD44v6 targeting antibody fragment with improved tumor-to-blood ratio

Sandstrï¿1⁄2m

2012

Int J Oncol

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Abstract. The chimeric monoclonal antibody U36 (cMAb U36) recognizes the CD44v6 antigen. Its potential as a radioimmunotargeting agent, as well as its safety, has been shown in previous studies in head and neck cancer patients. However, intact MAbs have long circulation time in the blood and tumor targeting may also be hampered due to the slow and incomplete diffusion into solid tumors. In comparison, smaller monovalent Fab' and divalent F(ab') 2 fragments are expected to exhibit shorter circulating half-lives, better tumor penetration and are thus more likely to yield better imaging results. In this study, novel F(ab') 2 and Fab' fragments from cMAb U36 were radiolabeled with 125 I and the characteristics of the conjugates in vitro were examined. The biodistribution of the conjugates were then evaluated in nude mice bearing CD44v6-expressing xenograft tumors. Furthermore, the penetration depth and distribution in tumor tissue was assessed by autoradiography in selected tumor samples. The in vitro experiments showed that the conjugates were stable and had intact affinity to CD44v6. The biodistribution study demonstrated superior tumor-toblood ratio for the novel cMAb U36 fragment 125 I-F(ab') 2 compared with both the intact MAb and the monovalent fragment form. Autoradiography also revealed better tumor penetration for 125 I-F(ab') 2 . This study demonstrates that the use of antibody fragments may improve radioimmunotargeting and possibly improve the management of head and neck malignancies.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A novel CD44v6 targeting antibody fragment with improved tumor-to-blood ratio

Sandstrï¿1⁄2m

2012

Int J Oncol

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“…Patients with lymph-node involvement have a worse prognosis (approximately 30%) than patients without lymph node involvement (Ͼ50% 5-year survival). 6,7 PET using the radiotracer 18 F FDG is widely used to evaluate patients with HNSCC. The hybrid technique, PET/CT, provides anatomic and functional information and can be performed as PET and DCT with intravenous contrast-enhancement (PET/ DCT) or PET and noncontrast CT (PET/CT) for attenuation correction and anatomic localization.…”

mentioning

confidence: 99%

Fluorodeoxyglucose–Positron-Emission Tomography Imaging of Head and Neck Squamous Cell Cancer

Subramaniam

Truong

Peller

et al. 2009

AJNR Am J Neuroradiol

107

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SUMMARY:The hybrid technique of PET/CT has significantly impacted the imaging and management of HNSCC since its introduction in 2001 and has become the technique of choice for imaging of this cancer. Diagnostic FDG-PET/CT is useful for identification of an unknown primary tumor, delineation of extent of primary tumor, detection of regional lymph node involvement even in a normal-sized node, detection of distant metastases and occasional synchronous primary tumor, assessment of therapy response, and long-term surveillance for recurrence and metastases. The role of PET/CT is evolving in radiation therapy planning. Combined diagnostic PET/CT provides the best anatomic and metabolic in vivo information for the comprehensive management of HNSCC.ABBREVIATIONS: CR ϭ complete response; DCT ϭ contrast enhanced diagnostic CT;18 F ϭ fluorine-18; FDG ϭ fluorodeoxyglucose; FDG-PET ϭ fluorodeoxyglucose-positron-emission tomography; FNA ϭ fine-needle aspiration; GTV ϭ gross tumor volume; HNSCC ϭ head and neck squamous cell carcinomas; IMRT ϭ intensity modulated radiation therapy; M ϭ metastasis; N ϭ node; PET ϭ positron-emission tomography; PTV ϭ planning target volume; RD ϭ residual disease; SCC ϭ squamous cell carcinoma; SUV ϭ standard uptake value; SUV max ϭ maximum SUV; T ϭ tumor M ore than 40,000 people are diagnosed with head and neck cancer each year in the United States.1 The overall annual mortality rate for this cancer in the United States is 23%, and the 5-year survival rate is 56%.1-3 More than 80% of early-stage tumors are cured, but nearly one-half of patients have evidence of advanced local disease or lymph node metastases at the time of diagnosis. Surgery and radiation therapy, either alone or in combination with chemotherapy, are used for definitive locoregional treatment of head and neck cancers. For patients with advancedstage and high-risk features, postoperative chemoradiation improves locoregional control and overall survival. 4,5 Cross-sectional imaging with CT and MR imaging is commonly used for tumor staging and may allow detection of subcentimeter lesions. Locoregional lymph node metastases have a major impact on survival. Patients with lymph-node involvement have a worse prognosis (approximately 30%) than patients without lymph node involvement (Ͼ50% 5-year survival). 6,7 PET using the radiotracer 18 F FDG is widely used to evaluate patients with HNSCC. The hybrid technique, PET/CT, provides anatomic and functional information and can be performed as PET and DCT with intravenous contrast-enhancement (PET/ DCT) or PET and noncontrast CT (PET/CT) for attenuation correction and anatomic localization. PET/CT is useful for identification of an unknown primary tumor, delineation of the extent of regional lymph node involvement, detection of distant metastases and occasional synchronous primary tumor, radiation-therapy planning, assessing therapy response, and long-term surveillance for recurrence and metastases.PET/CT Protocols PET/CT imaging was developed to improve PET imaging by expediting attenuation c...

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“…Similarly, Anderson et al (2002) and Chepeha et al (2002) reported two-thirds of recurrences following SOHND to be in the field of dissection. Whitehurst and Droulias (1977) reported that 85% of the locoregional recurrences after surgical excision of tongue carcinoma occurred within 1 year, 95% within 2 years and 100% in 3 years. Similarly, for tumours of the floor of the mouth, Fu and colleagues (1976) reported that 90% of the local and regional neck recurrences occurred within the first 2 years.…”

Section: Discussionmentioning

confidence: 99%