Surgical Treatment of Renal Cell Carcinoma With Cavoatrial Involvement: A Systematic Review of the Literature

Gaudino, Mario; Lau, Christopher; Cammertoni, Federico; Vargiu, Virginia; Gambardella, Ivancarmine; Massetti, Massimo; Girardi, Leonard N.

doi:10.1016/j.athoracsur.2015.10.003

Cited by 25 publications

(25 citation statements)

References 68 publications

(79 reference statements)

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“…19 RCC represents 3% to 4% of all cancers, with about 5% to 10% presenting as extension IVC with tumor thrombus. 20,21 Combined excision of renal mass and its extension into IVC and RA as done by us has also been described by others. 22 5 years survival in RCC even with IVC involvement is 33% while those without IVC extension it is 52%.…”

Section: International Journal Of Contemporary Medical Researchsupporting

confidence: 57%

Surgical Treatment of Cardiac Tumors: A Single Institutional Experience Over 12 Years

Dasbaksi¹,

Hossain²,

Haldar³

et al. 2020

IJCMR

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Introduction: Tumors of the heart represent an exceedingly rare entity in cardiac surgery and literature regarding management and outcome is less in comparison to other fields of cardiac surgery. 12 years of our experience in both diagnosis and optimal surgical treatment of this small but rare collection of patients was formed into a detailed analysis of patient prognosis, mean survival and risk of tumor relapse matched to the corresponding pathology. The overall objective of the present study was a thorough characterization of both primary cardiac tumor or tumor like mass and secondary malignant tumor mass in cardiac chambers, their nature as well as age and gender distribution and management. Material and methods: 17 patients with cardiac tumors, who underwent open-heart surgery at Medical College and Hospitals, Kolkata, for tumor excision between 2007 and 2019 were analyzed retrospectively. Mean follow-up was from 11 to 1 years. Results: There were 2 males and 15 female patients ranging in age from 7 years to 60 years, median age being 47 years. 12 of these tumors were primary left atrial myxoma, 2 were right atrial myxoma, 1 was right ventricular fibroma, 1 was intravenous extension into right atrium of renal cell carcinoma and 1 was multiple inflammatory pseudo tumors in left ventricle. Overall operative survival was 88.3%. Operative mortality was 11.7%. Conclusion: Cardiac tumors remain challenging in the clinical setting. Early operation is recommended after echocardiographic diagnosis as such patients can have sudden death or severe cardiac failure during preoperative waiting period. Follow up should be maintained based upon the histopathological diagnosis.

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Section: International Journal Of Contemporary Medical Researchsupporting

confidence: 57%

Surgical Treatment of Cardiac Tumors: A Single Institutional Experience Over 12 Years

Dasbaksi¹,

Hossain²,

Haldar³

et al. 2020

IJCMR

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“…Currently, nephrectomy or partial nephron sparing resection represents the standard therapy for localized and locally advanced RCC. However, about 30% of RCC patients experience progression to metastatic or locally recurrent disease after nephrectomy for localized disease, and approximately 11% of patients will die of disease progression after surgery [4–6]. RCC is a heterogeneous disease with outcomes difficult to predict.…”

Section: Introductionmentioning

confidence: 99%

Aberrant Promoter Methylation of PCDH17 (Protocadherin 17) in Serum and its Clinical Significance in Renal Cell Carcinoma

Lin

Wang

et al. 2017

Med Sci Monit

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BackgroundCurrent studies indicated that PCDH17 functions as a tumor suppressor, which is frequently inactivated by aberrant promoter methylation in urologic tumors. The main purpose of this study was to investigate the methylation status of PCDH17 in serum and its clinical significance in renal cell carcinoma (RCC).Material/MethodsThe methylation status of PCDH17 in serum samples of 142 RCC patients and 34 controls was evaluated by methylation-specific PCR (MSP). Then we correlated PCDH17 methylation status with the clinicopathologic features of RCC patients and patient outcomes.ResultsWe found that PCDH17 was more frequently methylated in RCC patients than in controls. Moreover, PCDH17 methylation in serum was significantly correlated with advanced stage (p=0.044), higher grade (p=0.019), lymph node metastasis (p=0.008) and tumor progression (p<0.001). In addition, patients with methylated PCDH17 had shorter progression-free survival (p<0.001) and overall survival (p=0.017) than patients without, and PCDH17 methylation in serum was an independent prognostic factor for worse progression-free survival (HR: 4.215, 95% CI: 1.376–9.032, p<0.001) and overall survival (HR: 5.092, 95% CI: 1.149–12.357, p=0.046) of patients with RCC.ConclusionsThe present study indicates that PCDH17 methylation in serum is a frequent event in RCC and associated with risk factors of poor outcomes. Moreover, PCDH17 methylation in serum is a potential prognostic biomarker for patients with RCC after surgery.

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“…The overall and disease-free survival rates of this type are poorer than type I tumors [12]. Complete surgical resection offers 40% to 70% 5-year survival in the absence of metastases or lymph node involvement, while survival is significantly lower (0% -20%) if metastases are present [5].…”

Section: Discussionmentioning

confidence: 93%

Successful Management of Pulmonary Tumor Embolism from Renal Cell Carcinoma

Sugiyama¹,

Watanuki²,

Okada³

et al. 2018

OJTS

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Although invasion of renal cell carcinoma (RCC) into the inferior vena cava is common, pulmonary tumor embolism is rare. We present a case of a pulmonary tumor embolism from type II papillary renal cell carcinoma successfully treated using a staged approach. Such staged procedures are particularly effective in cases of massive renal tumors. Pulmonary tumor embolectomy using normothermic cardiopulmonary bypass is considerably less invasive than under deep hypothermic circulatory arrest.

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Surgical Treatment of Renal Cell Carcinoma With Cavoatrial Involvement: A Systematic Review of the Literature

Cited by 25 publications

References 68 publications

Surgical Treatment of Cardiac Tumors: A Single Institutional Experience Over 12 Years

Surgical Treatment of Cardiac Tumors: A Single Institutional Experience Over 12 Years

Aberrant Promoter Methylation of PCDH17 (Protocadherin 17) in Serum and its Clinical Significance in Renal Cell Carcinoma

Successful Management of Pulmonary Tumor Embolism from Renal Cell Carcinoma

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