“…These are more or less pronounced depending on the size of the fistula (Ried, 1925;Adams, 1951). The peripheral effect has previously been studied in detail both experimentally (Robertson, Dennis & Elkin, 1950;Holman & Taylor, 1952;Schenk Jr, Martin, Leslie & Portin, 1960;Johnson Jr., Dart Jr., Peters & Steele, 1966) and clinically (Pemberton & Waugh, 1939;Epstein, Post & McDowell, 1953;Wood, Swan & Helmholz Jr, 1957) in cases of arteriovenous fistula in the extremities. Although increased blood flow in the neighbourhood of the shunt, due to increased collateral blood supply, can often be demonstrated, the main effect is a reduction of blood flow in the tissues distal to {he fistula.…”