Surgical treatment of pyoderma gangrenosum with negative pressure wound therapy and split thickness skin grafting under adequate immunosuppression is a valuable treatment option: Case series of 15 patients

Peristomal skin complications: what dermatologists need to know

“…In this case, stoma accessories are recommended such as pastes or seals to help the pouch adhering to the skin surface . Surgical treatment with stoma relocation is associated with a high chance of recurrence, but stoma closure has been associated with no recurrence . Recent studies showed promising results with newer therapies such as cultured keratinocyte autografts, topical sucralfate, topical crushed prednisone, and biologic treatment …”

“…25 Surgical treatment with stoma relocation is associated with a high chance of recurrence, but stoma closure has been associated with no recurrence. 55 Recent studies showed promising results with newer therapies such as cultured keratinocyte autografts, topical sucralfate, topical crushed prednisone, and biologic treatment. [56][57][58][59] Koebnerization and other skin diseases Psoriasis and vitiligo both can be seen in periostomal skin because of repeated trauma (Fig.…”

Clinically inactive pyoderma gangrenosum successfully treated with negative pressure therapy and punch grafting

“…However, once inflammation is controlled by systemic immunosuppresion, these wounds may benefit from invasive treatments. [3][4][5] We present a case of pyoderma gangrenosum under immunosuppression, with no clinical signs of inflammation that responded successfully to negative pressure therapy and punch grafting.…”

“…Complete healing rates with classical immunosuppressive treatments (predominantly oral corticosteroids and cyclosporine) do not reach 50% at 6 months. 3,4 Although different biologic agents may be an effective alternative in nonresponders, the problem is not only controlling pyoderma activity but also repairing all lost tissue.…”

Absence of donor‐site pathergy following fractional autologous full‐thickness skin grafting in pyoderma gangrenosum

“…Pichler et al . have shown that treatment of PG with negative pressure wound therapy and STSG under adequate immunosuppression may be a valuable option in a case series of 15 patients . However, in that series STSGs still led to donor‐site morbidity and operating room costs.…”