Surgical Treatment of Pyoderma Gangrenosum with Negative Pressure Wound Therapy and Skin Grafting, Including Xenografts: Personal Experience and Comprehensive Review on 161 Cases

The role of negative pressure wound therapy (NPWT) on the treatment of pyoderma gangrenosum: A systematic review and personal experience

“…healed in more than 2 months. This association was significant (p = 0.02) and shows that adding a skin graft to NPWT improves healing time as previously reported by Eisendle et al 40 Pain relief from the PG wound has also been reported with the use of NPWT, but it remains controversial. 58 Other authors suggest that there is no reduction in wound pain or report pain when changing the dressing.…”

“…38,39 For severe PG or recalcitrant disease, systemic treatment, such as systemic corticosteroids, and immunosuppressive drugs, such as cyclosporine, are extremely important, as they act to reverse the pathological process of dysregulation of the innate immune system. 38,40 So, it is important to highlight that NPWT by itself should not be considered curative for pyo- or gauze (mechanotransduction). 2,41 In this way, the wound will be prepared for skin grafting as we reported with our two cases or healing by the second intention.…”

“…WhiteFoam) was also reported. 40 Birke et al recommended that NPWT be used with a pressure level between 50 and 150 mmHg. 67 Most of the articles included in this review did not describe the pressure level used.…”

Pyoderma gangrenosum secondary to caesarean section treated with negative pressure wound therapy and skin graft

“…NPWT and skin graft are helpful in reducing pain and shortening overall treatment time and have been successfully applied in PG patient. [7][8][9] Our case also showed that it is safe and effective to treat PG with NPWT and skin graft.…”

Pyoderma Gangrenosum: A Review of Updates in Diagnosis, Pathophysiology and Management

“…Additionally, there is recent literature outlining the use of surgical therapy in conjunction with immunosuppression, negative pressure wound therapy and skin grafting to treat PG lesions. This method has proven to be a safe and effective treatment option, with one study showing the successful treatment of lesions in 86% of the patients observed [43]. Continued research and stronger evidence in the form of large randomized controlled trials is needed to determine new therapeutic targets and effective treatment strategies for pyoderma gangrenosum.…”