Surgical treatment of pulmonary metastases in pediatric solid tumors

Heaton, Todd E.; Davidoff, Andrew M.

doi:10.1053/j.sempedsurg.2016.09.001

Cited by 46 publications

(56 citation statements)

References 88 publications

(93 reference statements)

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“…The COG, United Kingdom Children's Cancer Study Group (UKCCSG), and SIOP trials evaluated different approaches to the management of children with stage IV pulmonary-only FHWT, seeking to avoid the use of whole-lung irradiation (WLI) because of its significant acute and long-term toxicity [24]. In this cohort, there were 2 cases with treatmentrelated mortality, specifically from severe sepsis.…”

Section: Discussionmentioning

confidence: 99%

Management and outcome of pediatric metastatic Wilms’ tumor at the National Cancer Institute, Egypt

El‐Ayadi

Magdy

Khalil

et al. 2020

J Egypt Natl Canc Inst

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Background: Wilms' tumor (WT) is the most common renal malignant tumor of childhood. Metastatic WT has a worse prognosis than localized disease. This study aims to assess the clinical outcome and different prognostic factors that influence treatment outcome of pediatric metastatic WT cases treated at National Cancer Institute (NCI), Egypt, between January 2008 and December 2015. Medical records were retrospectively reviewed for clinical, radiological and histopathological data, treatment received, and survival outcome.Results: In the specified study period, 24/103 (23.3%) patients with WT were metastatic at presentation. The mean age was 5.25 ± 2.87 years (range 2.0-12.7). Abdominal swelling/mass was the commonest presentation (70.8%). Only 3 patients (12.5%) had combined lung and liver metastases while 21 patients (87.5%) had pulmonary-only metastases. All patients had favorable histology tumors with no anaplasia. Nine patients (37.5%) underwent upfront nephrectomy. Majority of patients (91.7%) had local stage III disease. Surgical complications were reported in 4 patients; 3 of them had up-front nephrectomy. Only 7/21 patients achieved rapid complete response of pulmonary nodules after 6 weeks of chemotherapy (CTH), and they had a better survival outcome. Patients were followed up till December 2017. Thirteen patients (54.1%) experienced events during the study period including 5 relapses, 6 cases with disease progression, and 2 patients died out of sepsis. The 3-year event-free and overall survival rates were 48.2% and 54.2%, respectively. Conclusion: Neo-adjuvant CTH followed by delayed nephrectomy seems more suitable approach in our institute. Pulmonary response to neo-adjuvant CTH appears to be a strong predictor for outcome.

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Section: Discussionmentioning

confidence: 99%

Management and outcome of pediatric metastatic Wilms’ tumor at the National Cancer Institute, Egypt

El‐Ayadi

Magdy

Khalil

et al. 2020

J Egypt Natl Canc Inst

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“…(Table 1). and small lesions 10,21 . Although there are studies that advocate its use, justified by the good correlation of tomography with intraoperative findings, it is known that CT accuracy is still insufficient 22,23 .…”

Section: Resultsmentioning

confidence: 97%

Metástases pulmonares em crianças: estamos operando desnecessariamente?

Pontes

Filho

Miranda

et al. 2018

Rev. Col. Bras. Cir.

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“…Following regional lymph nodes, the lung represents the most frequent site of metastasis for solid tumors (9,10). An in vitro model that mirrors the complex microenvironment and architecture of the human lung would enable an accurate assessment of the biology of tumor metastasis to the lung and also facilitate the development of therapeutic agents that specifically abrogate lung metastasis.…”

Section: Plid Recapitulates Lung Architecturementioning

confidence: 99%

Metastatic Tumor-in-a-Dish, a Novel Multicellular Organoid to Study Lung Colonization and Predict Therapeutic Response

et al. 2019

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Metastasis is a major cause of cancer-related deaths. A dearth of preclinical models that recapitulate the metastatic microenvironment has impeded the development of therapeutic agents that are effective against metastatic disease. Because the majority of solid tumors metastasize to the lung, we developed a multicellular lung organoid that mimics the lung microenvironment with air sac-like structures and production of lung surfactant protein. We used these cultures, called primitive lung-in-a-dish (PLiD), to recreate metastatic disease using primary and established cancer cells. The metastatic tumor-in-a-dish (mTiD) cultures resemble the architecture of metastatic tumors in the lung, including angiogenesis. Pretreating PLiD with tumor exosomes enhanced cancer cell colonization. We next tested the response of primary and established cancer cells to current chemotherapeutic agents and an anti-VEGF antibody in mTiD against cancer cells in two-dimensional (2D) or 3D cultures. The response of primary patient-derived colon and ovarian tumor cells to therapy in mTiD cultures matched the response of the patient in the clinic, but not in 2D or single-cell-type 3D cultures. The sensitive mTiD cultures also produced significantly lower circulating markers for cancer similar to that seen in patients who responded to therapy. Thus, we have developed a novel method for lung colonization in vitro, a final stage in tumor metastasis. Moreover, the technique has significant utility in precision/personalized medicine, wherein this phenotypic screen can be coupled with current DNA pharmacogenetics to identify the ideal therapeutic agent, thereby increasing the probability of response to treatment while reducing unnecessary side effects. Significance: A lung organoid that exhibits characteristics of a normal human lung is developed to study the biology of metastatic disease and therapeutic intervention.

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Surgical treatment of pulmonary metastases in pediatric solid tumors

Cited by 46 publications

References 88 publications

Management and outcome of pediatric metastatic Wilms’ tumor at the National Cancer Institute, Egypt

Management and outcome of pediatric metastatic Wilms’ tumor at the National Cancer Institute, Egypt

Metástases pulmonares em crianças: estamos operando desnecessariamente?

Metastatic Tumor-in-a-Dish, a Novel Multicellular Organoid to Study Lung Colonization and Predict Therapeutic Response

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