Surgical treatment of post-infectious hydrocephalus in infants

Padayachy, L.; Ford, Lattimer H.; Dlamini, Nomusa R.; Mazwi, A.

doi:10.1007/s00381-021-05237-1

Cited by 4 publications

(5 citation statements)

References 72 publications

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“…Additionally, Kutty et al study revealed an average duration of 40 days (range 20–60 days) until resolution of infection occurs [ 20 ]. An essential factor which enhances durability is the absorptive capacity of the subgaleal space and the formation of generous spaces during the dissection process [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative study between ventriculosubgaleal shunt and external ventricular drain for management of post infective hydrocephalus among pediatrics

Ismail,

Taha,

Badr

et al. 2024

Childs Nerv Syst

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Purpose Post infective hydrocephalus (PIH) is a type of hydrocephalus which occurs after an infection of the brain or cerebrospinal fluid (CSF). Treatment of PIH requires temporary measures such as external ventricular drain (EVD) and ventriculosubgaleal shunt (VSGS) until CSF becomes clear and ready to implement VP shunt. Limited research has been done to explore the tradeoff between these approaches particularly in pediatric PIH patients. Our study compares the complications, mortality rates, and the cost of used resources of both procedures. Methods A prospective study was conducted for 18 months in which we compared between VSGS and EVD for management of PIH involving 42 randomized cases with 21 patients in group A operated by VSGS and 21 patients in group B operated by EVD. Results Our results show a statistically significant difference between both groups in the duration of implementation of VSGS/EVD until resolution of infection occurs. Additionally, a higher rate of pediatric intensive care unit (PICU) admission and a longer length of hospital stay (LOS) were recorded among the EVD group. No statistically significant difference between the number of complications that happened in both despite variations in their forms. Moreover, both groups showed nearly similar mortality rates. Conclusion There is no significant difference in the rate of complications between VSGS and EVD for PIH. Based on that, VSGS emerges as a favorable and cost-effective option for the management of PIH which leads to less economic burden on patients and the country’s health resources, especially in developing countries.

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Section: Discussionmentioning

confidence: 99%

Comparative study between ventriculosubgaleal shunt and external ventricular drain for management of post infective hydrocephalus among pediatrics

Ismail,

Taha,

Badr

et al. 2024

Childs Nerv Syst

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“…Notably, we observed a significant alleviation of intracranial pressure post-shunt surgery, a finding that aligns closely with previous research [ 15 ]. The use of a pressure-adjustable shunt valve enabled dynamic regulation of intracranial pressure, providing unique advantages in managing this critical parameter [ 16 ]. Following VPS surgery, we observed a significant improvement in the biochemical markers of cerebrospinal fluid (CSF) in patients.…”

Section: Discussionmentioning

confidence: 99%

Ventriculoperitoneal shunt for tuberculous meningitis-associated hydrocephalus: long-term outcomes and complications

Zhang,

Li,

Wen

et al. 2023

BMC Infect Dis

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Background Hydrocephalus is a frequent complication of tuberculous meningitis (TBM), and ventriculoperitoneal shunt (VPS) has been shown to improve short-term prognosis for patients with TBM-associated hydrocephalus. However, questions remain about long-term prognosis and shunt-related complications. This study aims to provide a comprehensive assessment of both long-term prognosis and shunt-related complications in patients with TBM-induced hydrocephalus who have undergone VPS treatment. Methods This retrospective study analyzed the clinical data of TBM patients with hydrocephalus treated with VPS at Peking Union Medical College Hospital between December 1999 and February 2023. Both short-term outcomes at discharge and long-term outcomes during follow-up were examined. Prognosis and shunt-related complications were assessed using the modified Rankin Scale (mRS) and the Activity of Daily Living (ADL) score to evaluate neurological function and autonomic living ability, respectively. Results A total of 14 patients with TBM-associated hydrocephalus were included in this study. Of these, 92.9% (13/14) exhibited favorable short-term outcomes, while 57.1% (8/14) showed positive long-term outcomes. Initial results indicated 6 complete recoveries (CR), 7 partial recoveries (PR), and 1 treatment failure. No catheter-related complications were observed initially. Long-term results included 4 CRs, 4 PRs, and 6 treatment failures. A variety of shunt surgery-related complications were noted, including three instances of catheter obstruction, one of incision infection, one of catheter-related infection, one of acute cerebral infarction, and one of transient peritoneal irritation accompanied by diarrhea. Conclusions VPS appears to be an effective and well-tolerated treatment for TBM-associated hydrocephalus, efficiently alleviating acute intracranial hypertension. Nonetheless, continuous long-term monitoring and proactive management are essential to mitigate the risk of catheter-related complications.

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“…The volume of the cranial part of the CSF is about 68% of the total volume of the craniospinal cavity, and the spinal part is 32%, respectively. Approximately 1/3 of the CSF volume is located in the ventricles of the brain, 1/3-in the subarachnoid cerebral and 1/3 of the volume-in the spinal subarachnoid spaces [4,5,[10][11][12].…”

Section: Structural Units Of the Cerebrospinal Fluid Circulation Systemmentioning

confidence: 99%

“…Within 2 minutes the background intracranial pressure, background spectral components of wave oscillations are recorded. Next, a saline solution is injected with a bolus volume of 2 ml at a rate of 1 ml/sec with an interval between boluses of 1 min [4,10,15,17] (Figure 3, A).…”

Section: Assessment Of Intracranial Hypertension and Hydrocephalus Sy...mentioning

confidence: 99%

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CSF Bypass Surgery in Children with Hydrocephalus: Modern Possibilities, Prospects and Ways of Solving the Correction of Complications

Samochernykh¹,

Zabrodskaya²,

Nikolaenko³

et al. 2023

Frontiers in Hydrocephalus

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The chapter discusses modern and promising approaches to the use of CSF shunting operations in children. CSF shunting operations remain the only effective method for correcting persistent CSF circulation disorders in CSF resorption disorders with the development of intracranial hypertension and hydrocephalus. The chapter is devoted to general ideas about CSF dynamics and biomechanical properties of the craniospinal system that affect CSF dynamics, and gives a pathogenetic assessment of CSF dynamics in the development of intracranial hypertension and hydrocephalus. Aspects of genetics and genomics of anomalies in hydrocephalus are touched upon. Pathological changes in the brain around old ventricular shunts are described. The authors consider the types of CSF shunting operations for hydrocephalus in children. Possible complications of CSF shunting operations are analyzed with the algorithm for their correction and management tactics for this group of patients.

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Surgical treatment of post-infectious hydrocephalus in infants

Cited by 4 publications

References 72 publications

Comparative study between ventriculosubgaleal shunt and external ventricular drain for management of post infective hydrocephalus among pediatrics

Comparative study between ventriculosubgaleal shunt and external ventricular drain for management of post infective hydrocephalus among pediatrics

Ventriculoperitoneal shunt for tuberculous meningitis-associated hydrocephalus: long-term outcomes and complications

CSF Bypass Surgery in Children with Hydrocephalus: Modern Possibilities, Prospects and Ways of Solving the Correction of Complications

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