Surgical Treatment of Pancreatic Metastases from Renal Cell Carcinomas

Abstract

Pancreatic metastases from a renal cell carcinoma are rare and may occur long after manifestation of the primary disease. Resection of the metastases should be regarded as the best treatment. In our center, owing to the slow evolution of these secondaries, we perform resections capable of limiting the destruction of the pancreatic parenchyma as far as possible. The use of ‘atypical’ resections of the pancreas is characterized by a higher incidence of postoperative complications, particularly fistulas. Despite this, we believe that adjusted resection is to be advocated because of the possibility of additional remote secondaries, the shorter duration of surgery, the preservation of the glandular parenchyma and intact adjacent organs, such as duodenum, stomach, and spleen, and the fact that there have been no reports on local recurrences.

Pancreatic metastases: Observations of three cases and review of the literature

“…Their frequency at autopsy in patients with malignant neoplasms is variable from 3 to 10.6% [3,4]. In the clinical settings their incidence is lower: in the study of Roland and van Heerden [1] of 1,357 patients who had undergone surgical resection for primary malignant tumors of the pancreas, it did not exceed 2% of cases; Butturini et al [5] among 304 pancreatic cancers described 5 cases (1.6%) of pancreatic metastases; Faure et al [6] among 269 pancreatic resections for cancer reported 8 of them (3%). In our experience of 708 cases of pancreatic tumors we found 3 cases (0.4%) of pancreatic metastases.…”

Thyroid Metastases of Renal Cell Carcinoma: Clinical Course in 45 Patients Undergoing Surgery. Assessment of Factors Affecting Patients' Survival

“…Only six of the mentioned studies obtained complete information on the extrapancreatic metastases during the entire course of disease (28)(29)(30)(31)(32)37). In five publications comprising 65 patients, 7 patients could be identified also having thyroid metastases leading to the coincidence rate of 11% (26)(27)(28)32,37). Yet, no study on the thyroid or pancreatic metastases of RCC reports such a high coincidence up to date.…”

Emergency Pancreatoduodenectomy for Pancreatic Metastasis from Renal Cell Carcinoma in a Patient with von Hipple-Lindau Disease: A Case Report

“…The pancreas is a rare site of metastasis from other malignant tumors, accounting for 0.4% to 3.0% of surgically operated pancreatic tumors [3][4][5][6]. Primary tumors metastasizing to the pancreas include RCC (with a prevalence of 45%) and, more rarely, lung carcinoma (15%), breast carcinoma (8%), and colon carcinoma (7%) [6].…”