Surgical Treatment of Meningiomas - Outcome Associated With Type of Resection, Recurrence, Karnofsky Performance Score, Mitotic Count

Abstract

BACKGROUND: Meningiomas are the type of central nervous system tumours, derived from the cells of the arachnoid membrane that are well constrained from surrounding tissues, mainly no infiltrating neoplasm with benign features. Meningiomas consist about 15-20% of all primary intracranial neoplasms.
 AIM: The evaluation of the outcome of the operatively treated meningiomas in relation with the Karnofsky performance score, survival, recurrence, type of the surgical excision, histological type, mitotic count (MC), localisation and volume of the lesion
 METHODS: In this article 40 operatively treated patients are reviewed for the outcome of the operation about the Karnofsky performance score, survival, recurrence, type of the surgical excision, histological type, mitotic count (MC), localisation and volume of the lesion.
 RESULTS: Association/interconnection between the mitotic count grade I and the regrowth of meningioma have been verified. Association/interconnection between the mitotic count grade I and the regrowth of meningioma have been verified. Association/interconnection between the mitotic count grade I and the regrowth of meningioma have been established.
 CONCLUSION: Gender, age and Karnofsky performance score have predictive value in the treatment of different types of meningiomas. The magnitude of surgical resection is associated with the regrowth of a tumour. The mitotic count in different types of meningiomas presents significant feature in the appearance of meningioma recurrence. The surgical resection and the quality and quantity of patient’s survival have a significant relation to the mitotic count of the meningiomas. There is no connection between the size and the localisation of a tumour related to different values of the mitotic count.

Health-Related Quality of Life and Return to Work after Surgery for Spinal Meningioma: A Population-Based Cohort Study

“…In contrast, quality of life and return to work have been extensively studied in cranial meningiomas [ 19 , 20 , 21 , 22 ]. After surgery, anxiety, depression, and fatigue are common [ 23 , 24 , 25 , 26 , 27 , 28 ]. In the long term, quality of life may also be negatively affected by tumor recurrence, which is unexpectedly high in cranial meningiomas but not in spinal meningiomas [ 12 , 29 , 30 , 31 , 32 ].…”

“…Studies on return to work have indicated that 17–33% of the patients operated for cranial meningioma were unable to return to work [ 26 , 27 , 28 ]. A recent Swedish study on patterns of sick leave prior to surgery and return to work up to two years after surgery in patients with intracranial meningiomas, showed that 79.0% of the patients were working full time one year prior to surgery.…”

An Overview of Managements in Meningiomas

“…Robert Sumkovski et al found that sex, age, Karnofsky score etc. have predictive value for recurrence of different types of meningiomas (107). Histological grading of meningiomas also affects its recurrence, and with the increase of pathological grading, the recurrence rate increases greatly.…”

Retrospective Analysis and Comparison of 48 Intracranial Meningioma Cases As Two Groups According to Their Size

“…Although there are exceptions, there is a consensus that surgical resection of the tumor is the first option in treating meningioma. Wide surgical resection, histopathological grading, patient age, tumor size, and localization can be counted as prognostic factors for survival of the disease [16][17][18][19][20][21][22]. Some studies indicate that the recurrence rate of parasagittal and falcine meningiomas is higher than others.…”